2008
Childhood Disorders: The Pervasive Developmental Disorders
McPartland J, Klin A, Westphal A, Volkmar F. Childhood Disorders: The Pervasive Developmental Disorders. 2008, 779-803. DOI: 10.1002/9780470515167.ch45.ChaptersChildhood disintegrative disorderPervasive developmental disorderDevelopmental disordersAppropriate diagnostic assessmentRett disorderEtiologic featuresPsychiatric treatmentDiagnostic assessmentDisordersAtypical patternsAutistic disorderDisintegrative disorderDistinct phenotypicAutism spectrum disorderMultiple areasCurrent knowledgeSpectrum disorderAsperger's disorderDysfunction
2001
Methodological Issues in Designing a Multisite Trial of Risperidone in Children and Adolescents with Autism
Scahill L, McCracken J, McDougle C, Aman M, Arnold L, Tierney E, Cronin P, Davies M, Ghuman J, Gonzalez N, Koenig K, Lindsay R, Martin A, McGough J, Posey D, Swiezy N, Volkmar F, Ritz L, Vitiello B. Methodological Issues in Designing a Multisite Trial of Risperidone in Children and Adolescents with Autism. Journal Of Child And Adolescent Psychopharmacology 2001, 11: 377-388. PMID: 11838820, DOI: 10.1089/104454601317261555.Peer-Reviewed Original ResearchConceptsPlacebo-controlled studyPlacebo-controlled discontinuation studyAutistic disorderSafety of risperidoneStudy of RisperidoneStandard pharmacological treatmentSelf-injurious behaviorDiscontinuation studyPharmacological treatmentClinical trialsInclusion criteriaLong-term effectsSevere tantrumsTrial designClinical relevanceClinical practiceLength of trialRisperidoneMultisite trialStudy designContinuous treatmentTrialsTreatment effectsDisordersMaintenance phase
2000
Brief Report: Interrater Reliability of Clinical Diagnosis and DSM-IV Criteria for Autistic Disorder: Results of the DSM-IV Autism Field Trial
Klin A, Lang J, Cicchetti D, Volkmar F. Brief Report: Interrater Reliability of Clinical Diagnosis and DSM-IV Criteria for Autistic Disorder: Results of the DSM-IV Autism Field Trial. Journal Of Autism And Developmental Disorders 2000, 30: 163-167. PMID: 10832781, DOI: 10.1023/a:1005415823867.Peer-Reviewed Original Research
1997
Risperidone Treatment of Children and Adolescents With Pervasive Developmental Disorders: A Prospective, Open-Label Study
MCDOUGLE C, HOLMES J, BRONSON M, ANDERSON G, VOLKMAR F, PRICE L, COHEN D. Risperidone Treatment of Children and Adolescents With Pervasive Developmental Disorders: A Prospective, Open-Label Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 1997, 36: 685-693. PMID: 9136504, DOI: 10.1097/00004583-199705000-00020.Peer-Reviewed Original ResearchConceptsPervasive developmental disorderDevelopmental disordersRisperidone treatmentClinical Global Impression ScaleOpen-label studyOpen-label trialPlacebo-controlled studyCommon side effectsEfficacy of risperidoneShort-term safetyGlobal Impression ScaleGlobal improvement itemBehavioral ratingsChildhood disintegrative disorderSocial relatednessTreatment of childrenAsperger's disorderRepetitive behaviorsAutistic disorderBehavioral symptomsBaseline visitMean ageImpression ScaleAdolescentsOptimal dose
1996
A Double-blind, Placebo-Controlled Study of Fluvoxamine in Adults With Autistic Disorder
McDougle C, Naylor S, Cohen D, Volkmar F, Heninger G, Price L. A Double-blind, Placebo-Controlled Study of Fluvoxamine in Adults With Autistic Disorder. JAMA Psychiatry 1996, 53: 1001-1008. PMID: 8911223, DOI: 10.1001/archpsyc.1996.01830110037005.Peer-Reviewed Original ResearchConceptsStudy of FluvoxamineAutistic disorderSelective serotonin uptake inhibitorAdverse cardiovascular eventsPlacebo-controlled trialWeeks of treatmentSerotonin uptake inhibitorSerotonin neurotransmitter systemShort-term treatmentCardiovascular eventsPlacebo groupMild sedationNeurotransmitter systemsTreatment responseSafe drugUptake inhibitorFluvoxamineSymptoms of autismFluvoxamine maleateDisordersPlaceboAutistic behaviorPatientsAdultsSymptoms
1995
A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder
McDougle C, Kresch L, Goodman W, Naylor S, Volkmar F, Cohen D, Price L. A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder. American Journal Of Psychiatry 1995, 152: 772-777. PMID: 7726318, DOI: 10.1176/ajp.152.5.772.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRepetitive thoughtsAutistic disorderAutistic groupSex-matched adultsSymptom ChecklistObsessive-compulsive groupDirect discriminant function analysisYale-Brown Obsessive Compulsive Scale Symptom ChecklistYale-Brown Obsessive Compulsive ScaleObsessive-compulsive symptomsCompulsive Scale Symptom ChecklistObsessive Compulsive ScaleAutistic patientsCase-control studyNeurobiological underpinningsSelf-mutilating behaviorCompulsive ScaleDiscriminant function analysisSomatic contentCounting behaviorConsecutive patientsPrimary diagnosisDisorders ClinicTreatment response
1994
Field trial for autistic disorder in DSM-IV
Volkmar F, Klin A, Siegel B, Szatmari P, Lord C, Campbell M, Freeman B, Cicchetti D, Rutter M, Kline W. Field trial for autistic disorder in DSM-IV. American Journal Of Psychiatry 1994, 151: 1361-1367. PMID: 8067493, DOI: 10.1176/ajp.151.9.1361.Peer-Reviewed Original ResearchMeSH KeywordsAge of OnsetAutistic DisorderChildChild Development Disorders, PervasiveDiagnosis, DifferentialEvaluation Studies as TopicFalse Positive ReactionsFemaleHumansIntellectual DisabilityMaleMutismPredictive Value of TestsPsychiatric Status Rating ScalesReproducibility of ResultsSensitivity and SpecificityTerminology as TopicLithium Augmentation of Fluvoxamine in Autistic Disorder: A Case Report
EPPERSON C, McDOUGLE C, ANAND A, MAREK G, NAYLOR S, VOLKMAR F, COHEN D, PRICE L. Lithium Augmentation of Fluvoxamine in Autistic Disorder: A Case Report. Journal Of Child And Adolescent Psychopharmacology 1994, 4: 201-207. DOI: 10.1089/cap.1994.4.201.Peer-Reviewed Original ResearchSerotonin uptake inhibitorLithium augmentationUptake inhibitorAutistic disorderMinimal clinical responseSubstantial clinical improvementWeeks of treatmentSingle case reportsSignificant adverse effectsClinical improvementClinical responseClinical evidenceCase reportSerotonin functionFluvoxamineMeaningful improvementsTreatment of autismPatientsMarked reductionRating ScaleAdverse effectsRelative efficacyDisordersWeeksTreatmentRecent Advances in the Pharmacotherapy of Autism and Related Conditions
McDougle C, Price L, Volkmar F. Recent Advances in the Pharmacotherapy of Autism and Related Conditions. Child And Adolescent Psychiatric Clinics Of North America 1994, 3: 71-89. DOI: 10.1016/s1056-4993(18)30516-9.Peer-Reviewed Original Research
1992
Clomipramine in Autism: Preliminary Evidence of Efficacy
MCDOUGLE C, PRICE L, VOLKMAR F, GOODMAN W, WARD-O'BRIEN D, NIELSEN J, BREGMAN J, COHEN D. Clomipramine in Autism: Preliminary Evidence of Efficacy. Journal Of The American Academy Of Child & Adolescent Psychiatry 1992, 31: 746-750. PMID: 1644740, DOI: 10.1097/00004583-199207000-00025.Peer-Reviewed Original ResearchConceptsAutistic disorderPreliminary evidenceObsessive-compulsive symptomsSocial relatednessImpulsive behaviorCompulsive symptomsEfficacy of clomipramineYoung adultsPrevious evidenceClomipramine treatmentSerotonin neurotransmissionDisordersAutismClomipramineSymptomsTreatmentEfficacySignificant improvementAdultsEvidenceOutpatientsPathophysiologyNeurotransmissionRelatednessFindings