2016
Type 2 Diabetes Mellitus in Youth Exposed to Antipsychotics: A Systematic Review and Meta-analysis
Galling B, Roldán A, Nielsen RE, Nielsen J, Gerhard T, Carbon M, Stubbs B, Vancampfort D, De Hert M, Olfson M, Kahl KG, Martin A, Guo JJ, Lane HY, Sung FC, Liao CH, Arango C, Correll CU. Type 2 Diabetes Mellitus in Youth Exposed to Antipsychotics: A Systematic Review and Meta-analysis. JAMA Psychiatry 2016, 73: 247. PMID: 26792761, DOI: 10.1001/jamapsychiatry.2015.2923.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosT2DM riskHealthy controlsCoprimary outcomesT2DM incidencePsychiatric controlsIncidence rateType 2 diabetes mellitus riskMain modifiable risk factorsMultivariable meta-regression analysisSecond-generation antipsychotic prescriptionsCardiometabolic adverse effectsExposure-adjusted incidenceT2DM incidence rateModifiable risk factorsDiabetes mellitus riskStudy-level dataAntipsychotic-treated youthSystematic literature searchMeta-regression analysisOlanzapine prescriptionOlanzapine treatmentSecondary outcomesT2DM developmentAntipsychotic prescriptions
2003
Which SSRI? A Meta-Analysis of Pharmacotherapy Trials in Pediatric Obsessive-Compulsive Disorder
Geller DA, Biederman J, Stewart SE, Mullin B, Martin A, Spencer T, Faraone SV. Which SSRI? A Meta-Analysis of Pharmacotherapy Trials in Pediatric Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2003, 160: 1919-1928. PMID: 14594734, DOI: 10.1176/appi.ajp.160.11.1919.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsObsessive-compulsive disorderStandardized mean differenceOutcome measuresMean differenceStudy designSerotonin reuptake inhibitorsDependent outcome measuresAdolescent obsessive-compulsive disorderSystematic literature searchMultivariate regression analysisPediatric obsessive-compulsive disorderTypes of drugsEffect sizePlacebo treatmentMedication trialsReuptake inhibitorsOutcome scoresPharmacological treatmentPharmacotherapy trialsOverall effect sizeInclusion criteriaClinical careDrug effectsMeta-Analysis