Sujin Kim
Associate Research ScientistCards
About
Research
Publications
2024
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease.
Park S, Park CW, Eom JH, Jo MY, Hur HJ, Choi SK, Lee JS, Nam ST, Jo KS, Oh YW, Lee J, Kim S, Kim DH, Park CY, Kim SJ, Lee HY, Cho MS, Kim DS, Kim DW. Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease. Cell Stem Cell 2024, 31: 278-279. PMID: 38306996, DOI: 10.1016/j.stem.2024.01.006.Peer-Reviewed Original Research
2023
SLIC-Occ: functional segmentation of occupancy images improves precision of EC50 images
Ibrahimy A, Hoye J, Wu H, de Laat B, Kim S, Wilson D, Morris E. SLIC-Occ: functional segmentation of occupancy images improves precision of EC50 images. EJNMMI Physics 2023, 10: 80. PMID: 38079001, PMCID: PMC10713928, DOI: 10.1186/s40658-023-00600-4.Peer-Reviewed Original Research
2022
Pharmacokinetic evaluation of radiolabeled intraocular anti-CLEC14a antibody in preclinical animal species and application in humans.
Park S, Lee YW, Oh J, Kim SJ, Lee S, Lee HY. Pharmacokinetic evaluation of radiolabeled intraocular anti-CLEC14a antibody in preclinical animal species and application in humans. Clin Transl Sci 2022, 15: 2938-2946. PMID: 36129122, DOI: 10.1111/cts.13412.Peer-Reviewed Original ResearchIn vivo molecular imaging in preclinical research.
Kim SJ, Lee HY. In vivo molecular imaging in preclinical research. Lab Anim Res 2022, 38: 31. PMID: 36266669, DOI: 10.1186/s42826-022-00142-3.Peer-Reviewed Original ResearchOne-pot bifunctionalization of silica nanoparticles conjugated with bioorthogonal linkers: application in dual-modal imaging.
Lee J, Kim J, Heo I, Kim SJ, Jang S, Lee HY, Jang KS, Yang CS, Lee Y, Yoo WC, Min SJ. One-pot bifunctionalization of silica nanoparticles conjugated with bioorthogonal linkers: application in dual-modal imaging. Biomater Sci 2022, 10: 3540-3546. PMID: 35611753, DOI: 10.1039/d2bm00258b.Peer-Reviewed Original Research
2021
Topoisomerase IIIβ Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice.
Rahman FU, Kim YR, Kim EK, Kim HR, Cho SM, Lee CS, Kim SJ, Araki K, Yamamura KI, Lee MN, Park SG, Yoon WK, Lee K, Won YS, Kim HC, Lee Y, Lee HY, Nam KH. Topoisomerase IIIβ Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice. Int J Mol Sci 2021, 22 PMID: 34884616, DOI: 10.3390/ijms222312806.Peer-Reviewed Original Research
2020
Robust nonlinear parameter estimation in tracer kinetic analysis using infinity norm regularization and particle swarm optimization.
Kang SK, Seo S, Lee CH, Kim MJ, Kim SJ, Lee JS. Robust nonlinear parameter estimation in tracer kinetic analysis using infinity norm regularization and particle swarm optimization. Phys Med 2020, 72: 60-72. PMID: 32200299, DOI: 10.1016/j.ejmp.2020.03.013.Peer-Reviewed Original Research
2019
Development and In Vivo Evaluation of a κ-Opioid Receptor Agonist as a PET Radiotracer with Superior Imaging Characteristics
Li S, Zheng MQ, Naganawa M, Kim S, Gao H, Kapinos M, Labaree D, Huang Y. Development and In Vivo Evaluation of a κ-Opioid Receptor Agonist as a PET Radiotracer with Superior Imaging Characteristics. Journal Of Nuclear Medicine 2019, 60: 1023-1030. PMID: 30630942, PMCID: PMC6604690, DOI: 10.2967/jnumed.118.220517.Peer-Reviewed Original ResearchConceptsMultilinear analysis 1Κ-opioid receptor agonistCentral nervous system diseaseNervous system diseasesHigh specific bindingAgonist tracersGlobus pallidusReceptor abnormalitiesReceptor agonistFrontal cortexSystem diseasesPrimate brainReceptor occupancySuperior imaging characteristicsCingulate cortexAlzheimer's diseasePeak uptakeImaging characteristicsRhesus monkeysOptimal radiotracerPET studiesArterial input functionBlocking studiesPET radiotracersAnalysis 1
2016
A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking
Wang S, Kim S, Cosgrove KP, Morris ED. A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking. NeuroImage 2016, 146: 701-714. PMID: 27743899, PMCID: PMC5321849, DOI: 10.1016/j.neuroimage.2016.10.019.Peer-Reviewed Original ResearchConceptsNeurotransmitter responsesCigarette smokingDrug stimuliDA releaseDA activationBolus injectionMild shorteningPET scansOptimal timingSmokingDopamine responsePET dataLp-ntPETDose limitTime courseSex differencesScansLoss of sensitivityBehavioral tasksDrugsLinear parametric neurotransmitter PETLower dose limitSuch responsesResponseStimuliNoninvasive bi-graphical analysis for the quantification of slowly reversible radioligand binding.
Seo S, Kim SJ, Yoo HB, Lee JY, Kim YK, Lee DS, Zhou Y, Lee JS. Noninvasive bi-graphical analysis for the quantification of slowly reversible radioligand binding. Phys Med Biol 2016, 61: 6770-6790. PMID: 27580316, DOI: 10.1088/0031-9155/61/18/6770.Peer-Reviewed Original Research