HER2 Low Breast Cancer: New Clinical Entity or Testing Artifact
Should breast cancer patients with low but not negative tumor expression of HER2 be considered a distinct patient group that can be treated differently from patients with tumors that are HER2 negative or HER2 positive? That was the question posed during a session at the recent San Antonio Breast Cancer Symposium (SABCS) 2022.Source: Medscape
Yale Cancer Center Researchers Awarded Grants by Breast Cancer Research Foundation
The Breast Cancer Research Foundation (BCRF) Scientific Advisory Board and its Board of Directors recently announced its 2022 research grants, including six funded grants at Yale Cancer Center and Smilow Cancer Hospital awarded to Mehra Golshan, MD, MBA, Melinda Irwin, PhD, MPH, Ian Krop, MD, PhD, Lajos Pusztai, MD, DPhil, David Rimm, MD, PhD, and Eric Winer, MD to support their research.
Yale Pathologists Participating in Annual USCAP Meeting to Share Research, Advancements
Pathologists and research scientists from Department of Pathology at Yale School of Medicine will be involved in more than 40 presentations and sessions at the United States and Canadian Academy of Pathology (USCAP) 2022 Annual Meeting in Los Angeles March 19-24.
Sex Differences in Brain Cell Development Offer Clues Into Disease Risk
A new Yale study reveals that astrocytes, a type of glial cell found in the central nervous system, develop at different rates in male and female mice, differences that could affect how neural networks are constructed and may have implications for disease risk. The findings were published Feb. 1 in Cell Reports.
Strategies to accelerate diagnosis and treatment of rare cardiovascular diseases
The current landscape for patients with rare cardiovascular disease has shifted. Using genome sequencing Yale physician-scientists have begun to elucidate the pathophysiology of genetic disorders and develop treatment guidelines and recommendations.
Researchers Identify Stem Cell Source of Key Process in Female Reproduction
Each month during women’s reproductive years, the uterus sheds and regenerates the tissue lining its walls in preparation for a pregnancy or the next cycle. The process behind this age-old and essential part of human reproduction is not well understood. But recent research led by Yale pathologist Wang Min identifies stem cells and a gene that contribute to this monthly event.
Yale Cancer Center Scientists Receive Grant to Advance Lung Cancer Research
Katerina Politi, PhD and Don Nguyen, PhD, members of the Signal Transduction Research Program at Yale Cancer Center (YCC), have received a 5-year, nearly $4 million National Cancer Institute (NCI) grant to support Lung Cancer research.
Genetic Sequencing Uncovers Causes for Mysterious Liver Disease in Adults
In up to 30% of individuals with chronic liver disease, the cause is unknown. To test for possible genetic factors in such cases, Yale researchers conducted whole-exome sequencing for a small group of patients, finding specific mutations that would have otherwise been missed. The results led to accurate diagnoses and informed treatment for a subset of the patient participants, the researchers said.
How do hair follicles grow? A Yale-led study untangles the science
An outstanding question in dermatology that researchers have studied for decades is: How do hair follicles emerge from a sea of seemingly uniform skin cells during embryonic development? New research findings from a Yale-led team offer answers to that question, which may lead to strategies for regenerating lost hair follicles in adults.
Yale experts treat severe, disfiguring sarcoidosis with novel therapy
An all-Yale team of researchers successfully treated a patient with disfiguring sarcoidosis, a disease that can affect multiple organs, with a drug approved for rheumatoid arthritis. Successful treatment of two other patients with similarly severe disease suggests an effective treatment for an incurable, sometimes life-threatening illness is within reach.
Yale Cancer Center Scientists Advise Caution in Immunotherapy Research
In a new study, Yale Cancer Center scientists suggest that as the number of clinical trials in cancer immunotherapy grows exponentially, some caution should be exercised as we continue to better understand the biology of these new therapeutic targets.
3-D Color X-Rays Could Help Spot Deadly Disease Without Surgery
Researchers in New Zealand have captured three-dimensional color X-rays of the human body, using an innovative tool that may eventually help diagnose cancers and blood diseases without invasive surgery. The new tool could serve as “a diagnostic road map to a destination,” according to Dr. Gary E. Friedlaender, an orthopedic surgeon at Yale University who treats bone cancers found in complex locations, such as inside the pelvis. “It’s about being able to first find the explanation for somebody’s symptoms, like a tumor, and then find the best way to reach it with the least amount of detours and misadventures,” he said. “We want to minimize the damage to normal tissues.”Source: NYT
Yale Cancer Researchers Suggest New Treatment for Rare Inherited Cancer
Studying two rare inherited cancer syndromes, Yale Cancer Center (YCC) scientists have found the cancers are driven by a breakdown in how cells repair their DNA. The discovery, published today in Nature Genetics, suggests a promising strategy for treatment with drugs recently approved for other forms of cancer.