Minghao Zhong, MD, PhD
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Appointments
Pathology
Primary
Contact Info
Yale School of Medicine
Pathology, 310 Cedar Street, PO Box 208023
New Haven, CT 06520-8023
United States
About
Titles
Associate Professor Adjunct in Pathology
Appointments
Pathology
Associate Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- GU Fellow
- Northwestern University (2012)
- Molecular and Genetic Pathology Fellow
- Mount Sinai Medical Center (2011)
- Resident
- University of Medicine & Dentistry of New Jersey (2010)
- Postdoctoral Fellow
- The Rockefeller University (2006)
- PhD
- The City University of New York, Molecular Cell Biology (2002)
- MD
- Tongji Medical College of Huazhong University of Science and Technology (1995)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Minghao Zhong's published research.
Publications Timeline
A big-picture view of Minghao Zhong's research output by year.
Fred Sanford Gorelick, MD
31Publications
894Citations
Publications
2022
A novel key driver gene of Alzheimer’s disease impacts AD‐related cognitive deficit, pathology and neuro‐inflammation in sex‐ and APOE‐specific manners
Cai D, Guo L, Cao J, Zhang L, Huang M, Hou J, Zhu L, Julia T, Zhong M, Goate A, Zhang B. A novel key driver gene of Alzheimer’s disease impacts AD‐related cognitive deficit, pathology and neuro‐inflammation in sex‐ and APOE‐specific manners. Alzheimer's & Dementia 2022, 17 DOI: 10.1002/alz.054111.Peer-Reviewed Original ResearchConceptsMolecular mechanismsGene co-expression network analysisCo-expression network analysisPossible post-translational modificationsGene perturbation studiesDimorphic expression patternPost-translational modificationsSystems biology approachSpecific mannerRNA expression datasetsKey driver genesSex-biased differenceMulti-omics dataSex-specific contributionsMultiscale network analysisLDL receptor-related proteinUptake of apoEBiology approachGene candidatesRegulator geneExpression patternsNetwork analysisReceptor-related proteinDriver genesExpression datasets
2020
A novel interaction between AD risk genes synaptojanin 1 and reticulon‐3 potentially impacts synaptic function and endo‐lysosomal trafficking during disease development and progression
Cai D, Huang M, Cao J, Hou J, Zhu L, Zhang L, Pero A, Guo L, Julia T, Zhong M, Goate A, Zhang B, Yan R. A novel interaction between AD risk genes synaptojanin 1 and reticulon‐3 potentially impacts synaptic function and endo‐lysosomal trafficking during disease development and progression. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043247.Peer-Reviewed Original ResearchConceptsSynaptic functionAPOE genotypeEndo-lysosomal traffickingReticulon 3Strongest genetic risk factorWhole brain lysateNon-demented subjectsPostmortem brain samplesGenetic risk factorsAMP-AD consortiumDifferent brain regionsHuman postmortem brain samplesLOAD patientsRisk factorsAD pathogenesisMolecular signaling mechanismsSporadic ADDisease pathogenesisSynaptosomal fractionBrain samplesMouse brainApoE4Brain regionsCognitive functionSynaptojanin 1A Comparative Analysis of Immunohistochemical Profile of Primary and Metastatic Endometrial Endometrioid Carcinoma
Xu K, Ye Q, Han L, Zhong M. A Comparative Analysis of Immunohistochemical Profile of Primary and Metastatic Endometrial Endometrioid Carcinoma. American Journal Of Clinical Pathology 2020, 154: s32-s33. DOI: 10.1093/ajcp/aqaa161.066.Peer-Reviewed Original ResearchConceptsEndometrial endometrioid carcinomaMetastatic carcinomaEndometrioid carcinomaNuclear beta-catenin stainingPrimary carcinomaImmunohistochemistry stainingBeta-catenin stainingEndometrioid carcinoma casesRetrospective institutional reviewMedian patient ageCommon metastatic siteBeta-catenin mutationsVariety of tumorsPatient ageMetastatic sitesPR expressionGrade IIIGrade IGrade IIImmunohistochemical profileCarcinoma casesIHC expressionINTRODUCTION/Cancer tumorigenesisCarcinoma
2019
Detecting FLI1 Fusion by Immunohistochemistry (IHC) Stain in Prostatic Adenocarcinoma
Xu K, Budhai A, Pattarkine R, Zhong M. Detecting FLI1 Fusion by Immunohistochemistry (IHC) Stain in Prostatic Adenocarcinoma. American Journal Of Clinical Pathology 2019, 152: s72-s73. DOI: 10.1093/ajcp/aqz113.087.Peer-Reviewed Original ResearchConceptsIHC stainsProstate cancerProstatic adenocarcinomaERG fusionNext-generation sequencingProstate adenocarcinoma casesTMA slidesE26 transformation-specific familyCommon genetic alterationsTissue microarray constructionAdenocarcinoma casesIHC stainingImmunohistochemistry stainsPositive casesMRNA level increasesTumor cellsNuclear stainingTCGA dataGenetic alterationsNontumor cellsSection slidesAdenocarcinomaCancerSurrogate testStain
2018
Orbital Lesions: A Retrospective Review From a Single Institute
Salib C, Adem P, Juechter K, Bortz J, Zhong M. Orbital Lesions: A Retrospective Review From a Single Institute. American Journal Of Clinical Pathology 2018, 150: s10-s10. DOI: 10.1093/ajcp/aqy090.023.Peer-Reviewed Original ResearchConceptsMarginal zone lymphomaOrbital lesionsRare entityPathological diagnosisAnatomical sitesComputerized tomographyMalignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsExtranodal marginal zone lymphomaRetrospective chart reviewFinal pathological diagnosisMetastatic breast carcinomaNerve sheath tumorsOrbital mass lesionsSquamous cell carcinomaBenign inflammatory conditionGranular cell tumorEpidermal inclusion cystRarity of lesionsChart reviewOrbital pseudotumorRetrospective reviewSheath tumorsSingle instituteSurgical excisionUtility of Pax2 and Bcl-2 Immunohistochemical Stains in Detecting Early Endometrioid Endometrial Carcinoma
Ye Q, Yoon E, Han L, Zhong M. Utility of Pax2 and Bcl-2 Immunohistochemical Stains in Detecting Early Endometrioid Endometrial Carcinoma. American Journal Of Clinical Pathology 2018, 150: s116-s117. DOI: 10.1093/ajcp/aqy098.280.Peer-Reviewed Original ResearchConceptsEndometrioid endometrial carcinomaProliferative endometriumWhole tissue sectionsTissue microarrayEndometrial carcinomaSerous carcinomaBcl-2ECC casesSerous carcinoma casesUseful immunohistochemical markerSecretory phase endometriumTissue sectionsTissue section examinationBcl-2 stainingIntensity of stainingBcl-2 expressionNormal endometriumLoss of expressionCarcinoma casesPhase endometriumImmunohistochemical stainsImmunohistochemical markersSection examinationEndometriumIHC stainsA Giant Fibroepithelial Polyp of the Small Bowel Associated with High-Grade Obstruction
Lee H, Sade I, Gilani S, Zhong M, Lombardo G. A Giant Fibroepithelial Polyp of the Small Bowel Associated with High-Grade Obstruction. The American Surgeon 2018, 84: 210-211. PMID: 30401014, DOI: 10.1177/000313481808400701.Peer-Reviewed Original ResearchCitationsFrom Bedside to Endoscopy to Microscopy to Diagnosis: Samples Collection and Processing
Yoon E, Zhong M. From Bedside to Endoscopy to Microscopy to Diagnosis: Samples Collection and Processing. 2018, 97-105. DOI: 10.1007/978-3-319-51263-1_9.Peer-Reviewed Original ResearchPathology of Urothelial Malignancies of the Upper Urinary Tract
Hajiyeva S, Zhong M. Pathology of Urothelial Malignancies of the Upper Urinary Tract. 2018, 107-117. DOI: 10.1007/978-3-319-51263-1_10.Peer-Reviewed Original ResearchConceptsUpper urinary tractUrothelial carcinomaNoninvasive urothelial carcinomaUrinary tractUpper urinary tract urothelial carcinomaUrinary tract urothelial carcinomaNon-urothelial malignancyInflammatory myofibroblastic tumorInvasive urothelial carcinomaUreteropelvic junction obstructionTumor-like conditionsDiverse treatment optionsIntratubular spreadImmunoglobulin G4Myofibroblastic tumorUrothelial malignancyTreatment optionsGlandular differentiationJunction obstructionRenal pelvisDifferent prognosisRhabdoid tumorMuscular conduitCarcinomaDisease pathology334 Whole Exome Sequencing of End Stage Renal Disease Associated Papillary Renal Cell Carcinoma (PRCCs)
Farooq T, Saeed F, Zhang D, Huang W, Yin C, Zhong M. 334 Whole Exome Sequencing of End Stage Renal Disease Associated Papillary Renal Cell Carcinoma (PRCCs). American Journal Of Clinical Pathology 2018, 149: s144-s144. DOI: 10.1093/ajcp/aqx127.333.Peer-Reviewed Original ResearchCitationsConceptsEnd-stage renal diseasePapillary renal cell carcinomaRenal cell carcinomaSporadic papillary renal cell carcinomasWhole-exome sequencingCell carcinomaExome sequencingSurgical pathology databaseSporadic renal cell carcinomaSpecific genetic alterationsParaffin-embedded tissuesGenomic DNARenal diseasePathology databaseCarcinomaProfile levelsGene mutationsGenetic mutationsGenetic alterationsFrequent mutationsMolecular changesSingle nucleotide variantsTargeted sequencingHuge overlapRNA kit
Academic Achievements and Community Involvement
honor Attending Teacher of the Year
Regional AwardWestchester Medical Center at New York Medical CollegeDetails06/30/2014United Stateshonor The C.H. Li Memorial Scholarship
National AwardRockefeller UniversityDetails06/30/2002United Stateshonor Mina Rees Award for Excellence in Research and Teaching
Regional AwardHunter College of The City University of New YorkDetails06/30/2001United States
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Yale School of Medicine
Pathology, 310 Cedar Street, PO Box 208023
New Haven, CT 06520-8023
United States
Locations
Pathology
Academic Office
Lauder Hall
310 Cedar Street, Rm LH 108F
New Haven, CT 06510
Business Office
203.737.4206