2022
A novel key driver gene of Alzheimer’s disease impacts AD‐related cognitive deficit, pathology and neuro‐inflammation in sex‐ and APOE‐specific manners
Cai D, Guo L, Cao J, Zhang L, Huang M, Hou J, Zhu L, Julia T, Zhong M, Goate A, Zhang B. A novel key driver gene of Alzheimer’s disease impacts AD‐related cognitive deficit, pathology and neuro‐inflammation in sex‐ and APOE‐specific manners. Alzheimer's & Dementia 2022, 17 DOI: 10.1002/alz.054111.Peer-Reviewed Original ResearchMolecular mechanismsGene co-expression network analysisCo-expression network analysisPossible post-translational modificationsGene perturbation studiesDimorphic expression patternPost-translational modificationsSystems biology approachSpecific mannerRNA expression datasetsKey driver genesSex-biased differenceMulti-omics dataSex-specific contributionsMultiscale network analysisLDL receptor-related proteinUptake of apoEBiology approachGene candidatesRegulator geneExpression patternsNetwork analysisReceptor-related proteinDriver genesExpression datasets
2020
A novel interaction between AD risk genes synaptojanin 1 and reticulon‐3 potentially impacts synaptic function and endo‐lysosomal trafficking during disease development and progression
Cai D, Huang M, Cao J, Hou J, Zhu L, Zhang L, Pero A, Guo L, Julia T, Zhong M, Goate A, Zhang B, Yan R. A novel interaction between AD risk genes synaptojanin 1 and reticulon‐3 potentially impacts synaptic function and endo‐lysosomal trafficking during disease development and progression. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043247.Peer-Reviewed Original ResearchSynaptic functionAPOE genotypeEndo-lysosomal traffickingReticulon 3Strongest genetic risk factorWhole brain lysateNon-demented subjectsPostmortem brain samplesGenetic risk factorsAMP-AD consortiumDifferent brain regionsHuman postmortem brain samplesLOAD patientsRisk factorsAD pathogenesisMolecular signaling mechanismsSporadic ADDisease pathogenesisSynaptosomal fractionBrain samplesMouse brainApoE4Brain regionsCognitive functionSynaptojanin 1A Comparative Analysis of Immunohistochemical Profile of Primary and Metastatic Endometrial Endometrioid Carcinoma
Xu K, Ye Q, Han L, Zhong M. A Comparative Analysis of Immunohistochemical Profile of Primary and Metastatic Endometrial Endometrioid Carcinoma. American Journal Of Clinical Pathology 2020, 154: s32-s33. DOI: 10.1093/ajcp/aqaa161.066.Peer-Reviewed Original ResearchEndometrial endometrioid carcinomaMetastatic carcinomaEndometrioid carcinomaNuclear beta-catenin stainingPrimary carcinomaImmunohistochemistry stainingBeta-catenin stainingEndometrioid carcinoma casesRetrospective institutional reviewMedian patient ageCommon metastatic siteBeta-catenin mutationsVariety of tumorsPatient ageMetastatic sitesPR expressionGrade IIIGrade IGrade IIImmunohistochemical profileCarcinoma casesIHC expressionINTRODUCTION/Cancer tumorigenesisCarcinomaDetecting EGFR mutations (L858R, T790M) using allele specific multiplex sequencing: A comparison with Pyrosequencing and TruSeq
Vinayagamoorthy D, Walsh J, Gipson K, Ye F, Zhong M, Dahui Q, Vinayagamoorthy T. Detecting EGFR mutations (L858R, T790M) using allele specific multiplex sequencing: A comparison with Pyrosequencing and TruSeq. Journal Of Solid Tumors 2020, 10: 19. DOI: 10.5430/jst.v10n1p19.Peer-Reviewed Original ResearchEGFR mutationsT790MMultiplex sequencingLate stage lung cancerDetect EGFR mutationsFFPE samplesEGFR somatic mutationsStage lung cancerLow copy numberLung cancer samplesDetect EGFRAnalytical lower limitL858RLung cancerTruSeqCopy numberDetect mutationsPyrosequencingT790EGFRSomatic mutationsCancer samplesMutationsFFPEConcordance
2019
Detecting FLI1 Fusion by Immunohistochemistry (IHC) Stain in Prostatic Adenocarcinoma
Xu K, Budhai A, Pattarkine R, Zhong M. Detecting FLI1 Fusion by Immunohistochemistry (IHC) Stain in Prostatic Adenocarcinoma. American Journal Of Clinical Pathology 2019, 152: s72-s73. DOI: 10.1093/ajcp/aqz113.087.Peer-Reviewed Original ResearchIHC stainsProstate cancerProstatic adenocarcinomaERG fusionNext-generation sequencingProstate adenocarcinoma casesTMA slidesE26 transformation-specific familyCommon genetic alterationsTissue microarray constructionAdenocarcinoma casesIHC stainingImmunohistochemistry stainsPositive casesMRNA level increasesTumor cellsNuclear stainingTCGA dataGenetic alterationsNontumor cellsSection slidesAdenocarcinomaCancerSurrogate testStain
2018
Orbital Lesions: A Retrospective Review From a Single Institute
Salib C, Adem P, Juechter K, Bortz J, Zhong M. Orbital Lesions: A Retrospective Review From a Single Institute. American Journal Of Clinical Pathology 2018, 150: s10-s10. DOI: 10.1093/ajcp/aqy090.023.Peer-Reviewed Original ResearchMarginal zone lymphomaOrbital lesionsRare entityPathological diagnosisAnatomical sitesComputerized tomographyMalignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsExtranodal marginal zone lymphomaRetrospective chart reviewFinal pathological diagnosisMetastatic breast carcinomaNerve sheath tumorsOrbital mass lesionsSquamous cell carcinomaBenign inflammatory conditionGranular cell tumorEpidermal inclusion cystRarity of lesionsChart reviewOrbital pseudotumorRetrospective reviewSheath tumorsSingle instituteSurgical excisionUtility of Pax2 and Bcl-2 Immunohistochemical Stains in Detecting Early Endometrioid Endometrial Carcinoma
Ye Q, Yoon E, Han L, Zhong M. Utility of Pax2 and Bcl-2 Immunohistochemical Stains in Detecting Early Endometrioid Endometrial Carcinoma. American Journal Of Clinical Pathology 2018, 150: s116-s117. DOI: 10.1093/ajcp/aqy098.280.Peer-Reviewed Original ResearchEndometrioid endometrial carcinomaProliferative endometriumWhole tissue sectionsTissue microarrayEndometrial carcinomaSerous carcinomaBcl-2ECC casesSerous carcinoma casesUseful immunohistochemical markerSecretory phase endometriumTissue sectionsTissue section examinationBcl-2 stainingIntensity of stainingBcl-2 expressionNormal endometriumLoss of expressionCarcinoma casesPhase endometriumImmunohistochemical stainsImmunohistochemical markersSection examinationEndometriumIHC stainsA Giant Fibroepithelial Polyp of the Small Bowel Associated with High-Grade Obstruction
Lee H, Sade I, Gilani S, Zhong M, Lombardo G. A Giant Fibroepithelial Polyp of the Small Bowel Associated with High-Grade Obstruction. The American Surgeon 2018, 84: 210-211. PMID: 30401014, DOI: 10.1177/000313481808400701.Peer-Reviewed Original ResearchFrom Bedside to Endoscopy to Microscopy to Diagnosis: Samples Collection and Processing
Yoon E, Zhong M. From Bedside to Endoscopy to Microscopy to Diagnosis: Samples Collection and Processing. 2018, 97-105. DOI: 10.1007/978-3-319-51263-1_9.Peer-Reviewed Original ResearchPathology of Urothelial Malignancies of the Upper Urinary Tract
Hajiyeva S, Zhong M. Pathology of Urothelial Malignancies of the Upper Urinary Tract. 2018, 107-117. DOI: 10.1007/978-3-319-51263-1_10.Peer-Reviewed Original ResearchUpper urinary tractUrothelial carcinomaNoninvasive urothelial carcinomaUrinary tractUpper urinary tract urothelial carcinomaUrinary tract urothelial carcinomaNon-urothelial malignancyInflammatory myofibroblastic tumorInvasive urothelial carcinomaUreteropelvic junction obstructionTumor-like conditionsDiverse treatment optionsIntratubular spreadImmunoglobulin G4Myofibroblastic tumorUrothelial malignancyTreatment optionsGlandular differentiationJunction obstructionRenal pelvisDifferent prognosisRhabdoid tumorMuscular conduitCarcinomaDisease pathology334 Whole Exome Sequencing of End Stage Renal Disease Associated Papillary Renal Cell Carcinoma (PRCCs)
Farooq T, Saeed F, Zhang D, Huang W, Yin C, Zhong M. 334 Whole Exome Sequencing of End Stage Renal Disease Associated Papillary Renal Cell Carcinoma (PRCCs). American Journal Of Clinical Pathology 2018, 149: s144-s144. DOI: 10.1093/ajcp/aqx127.333.Peer-Reviewed Original ResearchEnd-stage renal diseasePapillary renal cell carcinomaRenal cell carcinomaSporadic papillary renal cell carcinomasWhole-exome sequencingCell carcinomaExome sequencingSurgical pathology databaseSporadic renal cell carcinomaSpecific genetic alterationsParaffin-embedded tissuesGenomic DNARenal diseasePathology databaseCarcinomaProfile levelsGene mutationsGenetic mutationsGenetic alterationsFrequent mutationsMolecular changesSingle nucleotide variantsTargeted sequencingHuge overlapRNA kit344 Detection of ERG Rearrangement in Formalin-Fixed Paraffin-Embedded Tissue of Prostatic Adenocarcinoma by Targeted RNA-seq
Saeed F, Zhuge J, Huang W, Yang X, Volyanskyy K, Dimitrova N, Fallon J, Zhong M. 344 Detection of ERG Rearrangement in Formalin-Fixed Paraffin-Embedded Tissue of Prostatic Adenocarcinoma by Targeted RNA-seq. American Journal Of Clinical Pathology 2018, 149: s148-s148. DOI: 10.1093/ajcp/aqx127.343.Peer-Reviewed Original ResearchERG translocationProstate cancerProstatic adenocarcinomaTissue microarrayERG rearrangementErythroblast transformation-specific (ETS) transcription factorFusionPlex Solid Tumor KitAnchored multiplex PCRProstate cancer pathogenesisTMPRSS2-ERG fusion geneTMPRSS2-ERG fusionParaffin-embedded tissuesFrequent gene rearrangementsERG stainingIHC stainsNegative tissuesCancer pathogenesisGene rearrangementsRNA-seqTMA slidesAdenocarcinomaChromosomal translocationsFrequent eventCancerFusion gene
2017
[P4–043]: DEVELOPING NOVEL THERAPIES FOR ALZHEIMER'S DISEASE TARGETING BRAIN PHOSPHOLIPID DYSREGULATION
Cai D, Gaamouch F, Zhu L, Ohlmeyer M, Zhong M, Zhong M, Zhang B. [P4–043]: DEVELOPING NOVEL THERAPIES FOR ALZHEIMER'S DISEASE TARGETING BRAIN PHOSPHOLIPID DYSREGULATION. Alzheimer's & Dementia 2017, 13: p1272-p1273. DOI: 10.1016/j.jalz.2017.06.1907.Peer-Reviewed Original ResearchIdentification of distinctive patterns in cell signaling pathways in glioblastoma multiforme subtypes using gene expression TCGA data sets.
Volyanskyy K, Zhong M, Keswarpu P, Fallon J, Fanucchi M, Dimitrova N. Identification of distinctive patterns in cell signaling pathways in glioblastoma multiforme subtypes using gene expression TCGA data sets. Journal Of Clinical Oncology 2017, 35: e23162-e23162. DOI: 10.1200/jco.2017.35.15_suppl.e23162.Peer-Reviewed Original ResearchGene expression profilesPredictive genesCancer Genome AtlasG-CIMPTranscriptomic patternsRNAseq dataJAK-STATExpression profilesPathway interactionsBiological pathwaysNormal tissuesPI3K-AktCalcium signalingGenesGBM subtypesGene selectionGenome AtlasPotential therapeutic targetTCGA data setsPathwayPathway involvementTumor progressionTherapeutic targetDetected interactionsSubtype differentiation
2016
Benign and Malignant Brenner Tumors Show an Absence of TERT Promoter Mutations That Are Commonly Present in Urothelial Carcinoma
Khani F, Diolombi M, Khattar P, Huang W, Fallon J, Epstein J, Zhong M. Benign and Malignant Brenner Tumors Show an Absence of TERT Promoter Mutations That Are Commonly Present in Urothelial Carcinoma. The American Journal Of Surgical Pathology 2016, 40: 1291-1295. PMID: 27299795, DOI: 10.1097/pas.0000000000000680.Peer-Reviewed Original ResearchConceptsTERT promoter mutationsTransitional cell differentiationMalignant Brenner tumorBrenner tumorUrothelial carcinomaPromoter mutationsMetastatic urothelial carcinomaTransitional cell metaplasiaParaffin-embedded tissue blocksUncommon ovarian neoplasmsPolymerase chain reaction sequencingDistinct pathogenesisCell metaplasiaOvarian neoplasmsPrognostic roleImmunophenotypical featuresFallopian tubeRare caseTransitional epitheliumCell differentiationDiagnostic utilityTumorsTissue blocksReaction sequencingMetaplasiaSclerosing Pneumocytoma, A Mimicker of Lung Adenocarcinoma: Case Report
Saeed F, Zhong M. Sclerosing Pneumocytoma, A Mimicker of Lung Adenocarcinoma: Case Report. American Journal Of Clinical Pathology 2016, 146: 251. DOI: 10.1093/ajcp/aqw159.022.Peer-Reviewed Original ResearchLoss of Fructose-1,6-bisphosphatase 1 Expression in Kidney Neoplasm
Yoon E, Hajiyeva S, Barasch S, Volyanskyy K, Mao Y, Dimitrova N, Ronny F, Fallon J, Zhong M. Loss of Fructose-1,6-bisphosphatase 1 Expression in Kidney Neoplasm. American Journal Of Clinical Pathology 2016, 146: 319. DOI: 10.1093/ajcp/aqw159.090.Peer-Reviewed Original ResearchCarbonic Anhydrase (CAIX) Expression as Diagnostic Aid in Epithelial Ovarian Cancers and Its Clinical Implication
Farooq T, Pua T, Han L, Zhong M. Carbonic Anhydrase (CAIX) Expression as Diagnostic Aid in Epithelial Ovarian Cancers and Its Clinical Implication. American Journal Of Clinical Pathology 2016, 146: 2. DOI: 10.1093/ajcp/aqw161.002.Peer-Reviewed Original ResearchTFE3-Fusion Variant Analysis Defines Specific Clinicopathologic Associations Among Xp11 Translocation Cancers
Argani P, Zhong M, Reuter V, Fallon J, Epstein J, Netto G, Antonescu C. TFE3-Fusion Variant Analysis Defines Specific Clinicopathologic Associations Among Xp11 Translocation Cancers. The American Journal Of Surgical Pathology 2016, 40: 723-737. PMID: 26975036, PMCID: PMC4864095, DOI: 10.1097/pas.0000000000000631.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCarcinoma, Renal CellChildChild, PreschoolChromosomes, Artificial, BacterialChromosomes, Human, XFemaleHumansIn Situ Hybridization, FluorescenceKidney NeoplasmsMaleMelanomaMiddle AgedOncogene Proteins, FusionPerivascular Epithelioid Cell NeoplasmsTranslocation, GeneticYoung AdultConceptsRenal cell carcinomaGene fusionsMelanotic Xp11 translocation renal cancerXp11 translocation renal cell carcinomaTranslocation renal cell carcinomaBacterial artificial chromosome probesGene partnersClinicopathologic featuresClinicopathologic associationsRenal cancerFusion gene partnersClear cell papillary renal cell carcinomaPerivascular epithelioid cell tumorCathepsin KCellular contextPapillary renal cell carcinomaEpithelioid cell tumorRNA sequencingSpecific clinicopathologic featuresMesenchymal counterpartsIdentical gene fusionsOncogenic activationASPL-TFE3 gene fusionChromosome probesTFE3 gene fusions
2015
Frequency of Adrenal Gland Lesions in Tertiary Hospital Over 14 Years
Yoon E, Khattar P, Sann L, Zhong M. Frequency of Adrenal Gland Lesions in Tertiary Hospital Over 14 Years. American Journal Of Clinical Pathology 2015, 144: a372-a372. DOI: 10.1093/ajcp/144.suppl2.372.Peer-Reviewed Original Research