Research

Research is central to the mission of the Yale Department of Neurology. Advances in clinical care depend on understanding the fundamental mechanisms of nervous system disease and translating those discoveries into more effective diagnostic, preventive, and therapeutic strategies. Faculty in the Department pursue a broad and integrated research portfolio spanning molecular and cellular neuroscience, genetics and genomics, neuroimmunology, neurovascular biology, electrophysiology, systems neuroscience, computational neuroscience, imaging, pharmacology, and clinical investigation. These programs address major neurological disorders across the lifespan, including neurodegenerative disease, stroke and vascular cognitive impairment, epilepsy, neuromuscular disease, multiple sclerosis and other neuroimmunologic disorders, movement disorders, headache, neuro-oncology, and neurodevelopmental conditions. The Department is committed to bridging basic, translational, and clinical research. We actively promote collaboration among laboratory investigators, clinician-scientists, clinical trialists, computational scientists, and physician specialists to accelerate the movement of discoveries from the laboratory to patients and from clinical observation back to mechanistic investigation. Through this collaborative research environment, Yale Neurology faculty are advancing understanding of the nervous system, defining disease mechanisms, developing innovative technologies, and working toward new treatments for patients with neurological disease.