The O'Connor laboratory is part of the Department of Neurology and the Human Translational Immunology section of Immunobiology at Yale University School of Medicine. The major research interests of the O’Connor Laboratory include human neuroimmunology and autoimmunity. Our research is principally translational, highlighting a close collaboration with clinicians and integration with clinical trials. The intention of our work is to further elucidate the role that the immune system plays in autoimmune and neurological diseases. We are specifically interested in defining the mechanisms by which B cells, and the antibodies they produce, participate in disease pathology, how they damage tissue and organize at sites of such injury. To this end, we have developed innovative assays, fostered clinical collaborations, and built bio-repositories to underpin and enable cutting-edge research into the causes and treatment of autoimmune and neurological diseases. Areas of special interest to my group includes multiple sclerosis, neuromyelitis optica and most recently myasthenia gravis (MG).