Seth Herzon, PhD
Milton Harris ’29 Ph.D. Professor of ChemistryCards
About
Research
Overview
Research in my laboratory focuses on the total synthesis of complex secondary metabolites, with an emphasis on the synthesis and study of complex genotoxic natural products. We leverage our synthetic chemistry to elucidate the molecular basis of the phenotypic effects of the isolates. We also aim to develop new synthetic methods of general utility to overcome obstacles we encounter in our synthetic efforts. My laboratory has also studied host–microbe interactions with a focus on colibactin, a gut microbiome metabolite that induces colorectal cancer. Studies of DNA damage naturally lead to studies of DNA repair, and this line of inquiry has led me to develop novel chemotherapies to exploit tumor-associated DNA repair defects. Finally we have projects aimed at developing novel antibacterial agents.
News & Links
News
- February 28, 2025Source: Yale Ventures
YSM Faculty Win Awards From the Blavatnik Fund for Innovation at Yale
- February 11, 2025
Yale Advances in Treating Primary Brain Cancers Benefit Patients and Science
- January 09, 2025
Seth Herzon, PhD and Smita Krishnaswamy, PhD, Recipients of Yale Cancer Center Class of ‘61 Cancer Research Awards
- October 23, 2024Source: Yale Ventures
Yale Spinout Modifi Biosciences Acquired by Merck