Francis Lee, MD, PhD, FAAOS, MBA
Wayne O. Southwick Professor of Orthopaedics and RehabilitationCards
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View Doctor ProfileAdditional Titles
Professor, Biomedical Engineering
Professor, Graduate School of Arts and Sciences
with Tenure in Traditional Track
Professor in Department of Pathology, Secondary Appointment
Biological and Biomedical Science Program, YSM Postgraduate School
Wayne O. Southwick Endowed Professor in Orthopedics and Rehabilitation
Presidential Line Officer (Treasurer in 2023-Secretary in 2024-President-Elect in 2025-President in 2026), Executive Committee, Musculoskeletal Tumor Society
Contact Info
Orthopaedics & Rehabilitation
P.O. Box 208071
New Haven, CT 06520-8071
United States
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Professor, Biomedical Engineering
Professor, Graduate School of Arts and Sciences
with Tenure in Traditional Track
Professor in Department of Pathology, Secondary Appointment
Biological and Biomedical Science Program, YSM Postgraduate School
Wayne O. Southwick Endowed Professor in Orthopedics and Rehabilitation
Presidential Line Officer (Treasurer in 2023-Secretary in 2024-President-Elect in 2025-President in 2026), Executive Committee, Musculoskeletal Tumor Society
Contact Info
Orthopaedics & Rehabilitation
P.O. Box 208071
New Haven, CT 06520-8071
United States
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Professor, Biomedical Engineering
Professor, Graduate School of Arts and Sciences
with Tenure in Traditional Track
Professor in Department of Pathology, Secondary Appointment
Biological and Biomedical Science Program, YSM Postgraduate School
Wayne O. Southwick Endowed Professor in Orthopedics and Rehabilitation
Presidential Line Officer (Treasurer in 2023-Secretary in 2024-President-Elect in 2025-President in 2026), Executive Committee, Musculoskeletal Tumor Society
Contact Info
Orthopaedics & Rehabilitation
P.O. Box 208071
New Haven, CT 06520-8071
United States
About
Titles
Wayne O. Southwick Professor of Orthopaedics and Rehabilitation
Professor, Biomedical Engineering; Professor, Graduate School of Arts and Sciences; with Tenure in Traditional Track; Professor in Department of Pathology, Secondary Appointment; Biological and Biomedical Science Program, YSM Postgraduate School; Wayne O. Southwick Endowed Professor in Orthopedics and Rehabilitation
Positions outside Yale
Presidential Line Officer (Treasurer in 2023-Secretary in 2024-President-Elect in 2025-President in 2026), Executive Committee, Musculoskeletal Tumor Society
Biography
- Affiliation: Professor with Tenure, Unmodified Title; Wayne O. Southwick Professor; Orthopedic Surgeon and Scientist, Department of Orthopedic Surgery, School of Medicine, Yale University (2016-Present); Professor in Pathology, Secondary Appointment, Yale University (2017-Present); Professor in Biomedical Engineering, Secondary Appointment (2019-Present); Professor, Graduate School of Art and Science, Yale University (2019-Present); Professor with Tenure and Robert Carroll & Jane Chace Carroll Professor, Columbia University, New York (2012-2016); Orthopaedic Attending & Chief of Orthopaedic Oncology, New York Presbyterian Hospital, Columbia University Medical Center, New York (1999-2016)
- Clinical Practice Locations: Greenwich Hospital, Stamford Office, and Yale New Haven Hospital System
- Clinical Expertise: Sarcomas, Complex Musculoskeletal Reconstruction in Adults and Children; Musculoskeletal Bone and Soft Tissue Tumors (Benign Tumors and Cancers) & Complex Limb Reconstruction in Adults and Children; Pathological Fractures, Minimally Invasive Surgery for Metastatic Cancers to Bone (Breast, Prostate, Thyroid and Others); Failed Knee & Hip Implants; Osteomyelitis; Pediatric Orthopedics; Osteoid Osteoma, Enchondroma, Osteochondroma, Metabolic and Genetic Bone Diseases, Spine Tumors
- Research Interest: NIH R01-funded research programs in metastatic cancer-induced bone loss, fracture healing, regenerative orthopedics, and bone infection. Our lab is located in Tompkin 5 Orthopedic Research Laboratories.
- Administration: Vice Chair of Academic, Scientific, and Research Affairs (2016-2018; 2020-2023); Yale School of Medicine Admissions Committee; Yale University Saybrook College Advisor
- Education: American Board of Orthopaedic Surgery Written Question Task Force, Orthopaedic Research Society Mentorship Committee, New York Orthopaedic Pathology Review Course
- External Activities: NIH Skeletal Biology, Structure, and Regeneration (SBSR) Study Section Chair (2018-2020); Musculoskeletal Tumor Society Research Committee Chair (2017-2020); American Academy of Orthopaedic Surgeons Research Development Committee Chair (2019-2022); Orthopaedic Research and Education Foundation (OREF) Research Grant Committee Vice Chair (2019-2020); OREF Research Grant Chair & OREF Board of Directors; Board of Trustees (2020-2023)
- Musculoskeletal Tumor Society (MSTS) Presidential Line (2022-2023 Treasurer; 2023- 2024: Secretary; 2024-2025 President-Elect; 2025-2026 President); International Society of Limb Salvage (ISOLS) Board Member 2024-Present
- Research Programs and Major Research Grants
- NIH/NIAMS R01 AR081656-A1 (2024-202: PI: Francis Y. Lee, M.D.): Rescuing Impaired Fracture Healing by Molecular Targeting
- NIH/NIAMS R01 AR 073607 (2019-2024; PI: Francis Y. Lee, M.D.): PTH to rescue impaired fracture healing.
- NIH/NIAMS R01 (2015-2023; PI: Francis Y. Lee, M.D.): Infection and bone destruction; Eradication of bone destruction
- NIH/NCI R01 (2015-2022; PI: Francis Y. Lee, M.D.): Interactions between metastatic cancers and bone; Bone loss
- NIH/NIAMS R01 (2009-2019; PI: Francis Y. Lee, M.D.): Inflammation and bone loss; Osteoclastogenesis
- NIH/NIBIB R01 (Completed; 2007-2018; PI: Francis Y. Lee, M.D.): Biomaterials interface biology
- Musculoskeletal Transplantation Foundation (2013-2018): Enhanced Allograft Incorporation with Growth Factors
- NIAMS Mentored K08 Award (2017-2022; Mentor for PI Dr. David Koveacevic): Shoulder Inflammation
- Department of Defense (Completed; 2010-2015; PI: Francis Y. Lee, M.D.): 3D printed scaffolds for bone and cartilage defects
- External Scholarly Activities: Musculoskeletal Tumor Society Executive Committee member and Research Committee Chair (2017-2020); National Institute of Health Skeletal Biology, Structure and Regeneration(SBSR) Study Section Permanent Member (2015-2020) and Study Section Chair (2018-2020); Musculoskeletal Tumor Society (MSTS) Research Committee Chair (2018-2020); AAOS Tumor Program Committee (2016-2019); AAOS Research Development Committee Chair (2019-2022); Orthopaedic Research and Education Foundation (OREF) Research Grant Committee Vice Chair (2018-2020); Orthopaedic Research Society/International Society for Fracture Repair (ISFR) Board Member (2019-2021); Orthopaedic Research and Education Foundation (OREF) Research Grant Committee Chair (2020-Present); American Bone and Joint Surgery Member (2020-Present); AAOS Kappa Delta Award & OREF Clinical Research Award Selection Task Force Co-Chair
- Interactions with Undergraduate Students, YSM Medical Students, M.D.-Thesis Medical Students, M.D.-Ph.D. Candidate, Graduate Students, and Post-doctoral Fellows: Please send inquiries to francis.lee@yale.edu for research and clinical opportunities. Summer Research Fellow and One-Year YSM-sponsored Fellowships are provided.
- Mentoring and Supporting Junior Faculty, Fellows, and Residents: Assisting Career Development Awards or Grants. Academic Promotion Guidance; Primary Mentorship for NIAMS K08 Career Development Award for an Orthopaedic Surgeon at Yale Orthopaedics & Rehabilitation (2017-2022); Mentorship for OREF Residents & Faculty Award
- Yale University (2016 - Present): Yale University Saybrook College Fellow; Medical School Admissions Committee; Biological and Biomedical Science Program; Faculty, Yale university Art and Science Graduate School
- Columbia University, New York, and New York Presbyterian Hospital (1999 - 2016): Professor of Orthopaedic Surgery with Tenure (2012-2016), Robert Carroll and Jane Chace Carroll Professor (2014-2016), Associate Professor with Tenure (2009-2012), Associate Professor (2005-2009), Assistant Professor (1999-2005); Orthopedic Surgeon, New York Presbyterian Hospital, New York; Columbia University Senate Budget Review Committee (2011-2015)
Appointments
Orthopaedics & Rehabilitation
ProfessorPrimaryPathology
ProfessorSecondary
Other Departments & Organizations
- 3-D Patient-Specific Surgical Correction Program
- Cancer Signaling Networks
- Clinical Faculty
- Francis Lee Lab
- Molecular Medicine, Pharmacology, and Physiology
- Musculoskeletal Oncology
- Orthopaedics & Rehabilitation
- Pathology
- Pathology Research
- Sarcoma Program
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
Education & Training
- MBA
- Yale School of Management, Honorary MBA (2019)
- Honorary Executive MBA
- Yale School of Management (2018)
- Non Degree Program
- Hospital for Sick Chidren, Pediatric Orthopaedics Fellowship (1999)
- Clinical Orthopedic Fellowship
- Hospital for Sick Children, University of Toronto (1999)
- Non Degree Program
- Massachusetts General Hospital & Boston Children’s Hospital, Orthopaedic Oncology Fellowship (1998)
- Clinical Orthopedic Fellowship
- Harvard Medical School (Mass General Hospital & Boston Children's Hospital) (1998)
- Non Degree Program
- Rutgers Medical School, Orthopaedic Surgery Residency (1997)
- Orthopaedic Residency
- Rutgers New Jersey Medical School (1997)
- Non Degree Program
- Mount Sinai Hospital, Bone Research Fellowship (1996)
- Orthopedic Research Fellowship
- Mount Sinai School of Medicine (1996)
- PhD
- Seoul National University College of Medicine, Orthopedic Basic Science (1992)
- Orthopaedic Residency
- Seoul National University Hospital (1992)
- Non Degree Program
- Seoul National University Hospital, Orthopaedic Surgery Residency (1992)
- MD
- Seoul National University College of Medicine, Doctor of Medicine (1986)
- Premed & Doctor of Medicine
- Seoul National University College of Medicine (1986)
- Undergraduate Student
- University of Maryland at U.S. 8th Army, Seoul, Korea (1982)
Research
Overview
Clinical Research
Bone Defect Reconstruction & Regeneration
Metastatic Cancers to Bone, Pathological Fractures, Minimally Invasive Reconstruction of Pathological Fractures, AORIF (Ablation - Osteoplasty - Reinforcement - Internal Fixation)
Translational Research
Tissue Engineering, Bone Regeneration, Fracture Healing (Diabetes, Chronic Smoking, Infection), Bone Inflammation, Bone Infection, Cancer-Induced Bone Loss
Please refer to NIH RePorter on Descriptions of NIH-funded Research Programs.
My research group is committed to engaging undergraduate students, Yale medical students for Thesis, M.D.-Ph.D. Students, other graduate students, and visiting fellows for research opportunities and career advancement. For inquires, please contact francis.lee@yale.edu. I am an Orthopaedic Surgeon in active clinical practice and a Scientist fostering research experience for future clinician scholars and clinically relevant translational research scientists. I focus on high impact orthopaedic research that is directly relevant to pathogenesis, diagnosis, and treatment of Orthopaedic disorders.
Medical Research Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Gary Friedlaender, MD, BS
Dieter Lindskog, MD
Themis Kyriakides, PhD
Irvin Oh, MD, FAOA, FAAOS
Sang-Hun Kim
Thomas Hickernell, MD
Osteoblasts
Osteoclasts
Stem Cells
Bone and Bones
Tissue Engineering
Bone Marrow
Publications
Featured Publications
VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.
Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2023, 69: 22-33. PMID: 36450109, PMCID: PMC10324045, DOI: 10.1165/rcmb.2022-0219oc.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisImmune regulatorsTherapeutic potentialHuman idiopathic pulmonary fibrosisCrucial immune regulatorsNovel immune regulatorPulmonary fibrosis micePulmonary fibrosis modelNovel therapeutic targetRole of VISTAWild-type littermatesMonocyte-derived macrophagesT lymphocyte lineageVISTA expressionIPF treatmentAntibody treatmentImmune landscapeFibrotic mediatorsLung fibrosisFibrosis miceInflammatory responseFibrosis modelMyeloid populationsTherapeutic targetConcurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis
Kwon H, Yu K, Cahill S, Alder K, Dussik C, Kim S, Sharma L, Back J, Oh I, Lee F. Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis. EMBO Molecular Medicine 2022, 14: emmm202115284. PMID: 36354099, PMCID: PMC9728052, DOI: 10.15252/emmm.202115284.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDrug dimethyl fumarateSeptic arthritisIntracellular MRSABacterial joint infectionSoft tissue infectionsAnti-inflammatory effectsInfection-associated inflammationNovel therapeutic paradigmContext of infectionConventional antibiotic treatmentHost cellsAdjuvant administrationSurgical treatmentTissue infectionsClinical symptomsInflammatory machineryJoint infectionBacterial burdenAntibiotic treatmentCell inflammationHost inflammationArthritisInflammationIntraarticular inflammationTherapeutic paradigmInflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction
Back J, Nguyen MN, Li L, Lee S, Lee I, Chen F, Gillinov L, Chung YH, Alder KD, Kwon HK, Yu KE, Dussik CM, Hao Z, Flores MJ, Kim Y, Ibe IK, Munger AM, Seo SW, Lee FY. Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction. Bone Research 2021, 9: 43. PMID: 34588427, PMCID: PMC8481290, DOI: 10.1038/s41413-021-00158-w.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCancer-induced bone destructionBreast cancer cellsOsteolytic breast cancerBone homeostasisCancer growthCancer cellsBone destructionInflammatory osteolysisBreast cancerBreast cancer-induced bone destructionOsteolytic breast cancer metastasesPromising adjuvant therapyERK1/2 activationMEK1 expressionBreast cancer metastasisMetastatic breast cancer cellsActivation of pERK1/2Inflammatory conversionAdjuvant therapyPathological fracturesHuman pathological specimensBone microenvironmentPathological specimensSkeletal diseasePathway inhibitorEvolution of Surgical Management of Metastatic Disease of the Pelvis.
Benevenia J, Guinand LA, Ippolito J, Neilson JC, Fabbri N, Lee FY, Yang R, Kurland AM. Evolution of Surgical Management of Metastatic Disease of the Pelvis. Instructional Course Lectures 2022, 71: 185-201. PMID: 35254782.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSurgical managementSignificant pain reliefMetastatic bone diseaseRestoration of ambulationStandardized modalityPain reliefSevere painMetastatic diseasePostoperative periodSurgical treatmentMinimal complicationsSuccessful treatmentSurgical methodsSurgical reconstructionBone diseasePelvic lesionsInterventional methodsPatientsFrail stateMultidisciplinary approachDiseaseWound healingComplicationsLesionsLimited life spanAblation, Osteoplasty, Reinforcement, and Internal Fixation as a New Alternative First-Line Management for Osteolytic Pelvic Metastases.
Lee FY. Ablation, Osteoplasty, Reinforcement, and Internal Fixation as a New Alternative First-Line Management for Osteolytic Pelvic Metastases. Instructional Course Lectures 2022, 71: 213-220. PMID: 35254784.Peer-Reviewed Original ResearchBiomechanical restoration of metastatic cancer-induced peri-acetabular bone defects by ablation-osteoplasty-reinforcement-internal fixation technique (AORIF): To screw or not to screw?
Morris MT, Alder KD, Moushey A, Munger AM, Milligan K, Toombs C, Conway D, Lee I, Chen F, Tommasini SM, Lee FY. Biomechanical restoration of metastatic cancer-induced peri-acetabular bone defects by ablation-osteoplasty-reinforcement-internal fixation technique (AORIF): To screw or not to screw? Clinical Biomechanics 2022, 92: 105565. PMID: 34999389, DOI: 10.1016/j.clinbiomech.2021.105565.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCyclic loadingEnergy absorptionFinite element analysisHigh energy absorptionElement analysisBone defectsComposite boneStress relaxationSkeletal reinforcementReinforcement techniquesCement augmentation proceduresCementLoadingBone cement augmentationNumerous clinical advantagesBiomechanical testingPeriacetabular defectsFracture locationOsteolytic metastasesIntraarticular fracturesJoint preservationAcetabular augmentationCombination of screwsBiomechanical restorationFixation groupTreating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation
Kwon HK, Dussik CM, Kim SH, Kyriakides TR, Oh I, Lee FY. Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation. Frontiers In Cellular And Infection Microbiology 2022, 12: 897291. PMID: 35755835, PMCID: PMC9218192, DOI: 10.3389/fcimb.2022.897291.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSeptic arthritisBacterial burdenAntibiotic treatmentMurine modelTherapeutic goalsConcurrent antimicrobial therapyDistinct therapeutic goalsGeneration of inflammationMRSA septic arthritisSeptic knee arthritisInflammatory joint conditionsArticular cartilageMitigation of inflammationPost-antibiotic treatmentNovel therapeutic strategiesSeptic arthritis modelArticular cartilage damageEx vivo modelArticular cartilage integrityInflammatory arthritisInhibitors of ERKInflammatory profileMRSA infectionSynovial tissueExcessive inflammationEnhancement of Impaired MRSA‐Infected Fracture Healing by Combinatorial Antibiotics and Modulation of Sustained Inflammation
Yu KE, Kwon H, Dussik CM, Cahill SV, Back J, Alder KD, Lee FY. Enhancement of Impaired MRSA‐Infected Fracture Healing by Combinatorial Antibiotics and Modulation of Sustained Inflammation. Journal Of Bone And Mineral Research 2020, 37: 1352-1365. PMID: 35616626, DOI: 10.1002/jbmr.4570.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMethicillin-resistant Staphylococcus aureusExcessive inflammationAntibiotic treatmentFracture healingTrametinib therapyInfected fracturesPro-inflammatory cytokine levelsPostoperative antibiotic administrationSetting of infectionMale C57BL/6 miceSystemic antibiotic treatmentAdjunctive therapeutic agentMRSA-infected miceImpaired callus formationFemoral fracture modelTherapeutic cohortCytokine levelsMRSA infectionMusculoskeletal infectionsPostoperative intervalsSystemic vancomycinAntibiotic administrationCytokine analysisC57BL/6 miceIntramedullary nailingPercutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies.
Dussik C, Toombs C, Alder K, Yu K, Berson E, Ibe I, Li F, Lindskog D, Friedlaender G, Latich I, Lee F. Percutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies. Radiology 2023, 307: e221401. PMID: 36916888, DOI: 10.1148/radiol.221401.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOsteolytic neoplasmAmbulatory functionInternal fixationEastern Cooperative Oncology Group scoreIndex scoreConversion hip arthroplastyRetrospective observational studySurgical site infectionKaplan-Meier analysisLong-term painQuality of lifeLong-term improvementWilcoxon signed-rank testNonambulatory patientsSecondary outcomesPrimary outcomeSite infectionOncologic careECOG scorePercutaneous ablationPeriacetabular metastasisProtrusio acetabuliFunctional improvementSigned-rank testClinical dataComparison of Percutaneous Interventional Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF), Long Intramedullary Nailing, and Hemiarthroplasty for the Treatment of Focal Metastatic Osteolytic Lesions in the Femoral Head and Neck
Jiang W, Friedlaender G, Lindskog D, Latich I, Lee F. Comparison of Percutaneous Interventional Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF), Long Intramedullary Nailing, and Hemiarthroplasty for the Treatment of Focal Metastatic Osteolytic Lesions in the Femoral Head and Neck. CardioVascular And Interventional Radiology 2023, 46: 649-657. PMID: 37052716, DOI: 10.1007/s00270-023-03425-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOsteolytic lesionsFemoral headSurgical complicationsRevision proceduresLong intramedullary nailingResultsSixty-seven patientsPost-operative complicationsEffective alternative treatmentTraditional surgical approachesAmbulatory scoreCombined painPrimary outcomeMedical complicationsMetastatic lesionsOncologic careRetrospective studyIntramedullary nailingSurgical approachFunction scoresNeck lesionsEarly improvementIM groupHemiarthroplastyComparative efficacyAlternative treatment
Academic Achievements & Community Involvement
activity Orthopaedic Research and Education Foundation
Professional OrganizationsChairDetailsOREF Grant Committee Vice Chair (2018-2019); Chair (2019-Present); OREF Executive Board Committee02/01/2019 - Presentactivity Association of Bone and Joint Surgeons
Professional OrganizationsMemberDetails07/01/2020 - Presentactivity Musculoskeletal Tumor Society
Professional OrganizationsPresident-electDetailsTreasurer (2022-2023); Secretary (2023-2024); President-Elect (2025-2026); President (2026-2027)12/02/2022 - Presentactivity ISOLS Board
Advisory BoardsBoard MemberDetailsISOLS (International Society of Limb Salvage)2024 - Presentactivity MSTS
Professional OrganizationsPresident-electDetailsMusculoskeletal Tumor Society Presidential Line Treasure (2022-2023) Secretary (2023-2024) President-Elect (2024-2025) President (2025-2026)10/01/2022 - Present
Clinical Care
Overview
Francis Y. Lee, MD, PhD, is an orthopaedic surgeon with extensive expertise treating both adults and children. Committed to providing care of the highest quality, Dr. Lee works with a range of musculoskeletal problems, from fractures and limb deformities to musculoskeletal tumors and infections. He is an expert in complex musculoskeletal reconstruction.
A professor in the Department of Orthopaedics & Rehabilitation at Yale School of Medicine, Dr. Lee has a secondary appointment in the Department of Pathology. He holds the rare distinction of being both an orthopaedic surgeon and a musculoskeletal scientist scholar working with National Institutes of Health (NIH) research programs. Dr. Lee conducts extensive research into such areas as fracture healing and bone metastasis. Dr. Lee has been a pioneer in developing minimally invasive Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF) that is specially designed for patients with cancer that has spread to bone. This paradigm-shifting ambulatory procedure provides local cancer control, decreases pain, and improves ambulatory function.
Dr. Lee says he especially enjoys interacting with patients and their families. He draws upon his research background to approach each case with a sense of discovery and innovation. “I will provide care for you and your family as if I were treating my own family members and friends,” he says.
Dr. Lee also serves as a Presidential Line Officer (2022-2023: Treasurer; 2023-2034: Secretary; 2024-2025: President-Elect; 2025-2026: President) for the Musculoskeletal Tumor Society, a premier professional organization for musculoskeletal tumor surgeons.
Clinical Specialties
Fact Sheets
Bone Cancer
Learn More on Yale MedicineRunning Injuries
Learn More on Yale MedicineNeoplasm (Tumor)
Learn More on Yale MedicineGeriatric Hip Fractures
Learn More on Yale Medicine
Board Certifications
Orthopaedic Surgery
- Certification Organization
- AB of Orthopaedic Surgery
- Latest Certification Date
- 2022
- Original Certification Date
- 2001
Yale Medicine News
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View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileNews & Links
Media
- Minimally Invasive Ambulatory Procedure for Bone Destruction Secondary to Cancers (Impending Pathological Fractures): Percutaneous Ambulatory Procedure
News
- April 10, 2024
Six Faculty Selected as Research All Stars by Avant Garde Health
- November 29, 2023Source: Yale Medicine
When Metastatic Cancer Weakens Bone, the AORIF Procedure Can Help
- July 13, 2023Source: Orthopaedics Today
Minimally invasive procedure enhances care for periacetabular osteolytic metastasis
- July 01, 2020
Yale Orthopaedics & Rehabilitation Appoints Four New Vice Chairs
Get In Touch
Contacts
Orthopaedics & Rehabilitation
P.O. Box 208071
New Haven, CT 06520-8071
United States
Administrative Support
Locations
Department of Orthopaedics & Rehabilitation
Academic Office
47 College Street
New Haven, CT 06510
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.