Carmen Jane Booth, DVM, PhD
Associate Professor TermCards
About
Titles
Associate Professor Term
Director, Comparative Pathology Research, Comparative Medicine
Biography
My undergraduate work was in animal science pre vet followed by veterinary school where my emphasis was centered on clinical laboratory animal medicine and research. My interest in mouse pathology started while in veterinary school and continued while working as an oncology scientist and attending veterinarian for a biotech company before leaving to study veterinary pathology full time. Formal training in comparative anatomic veterinary pathology followed by a graduate study pathology in cellular signaling preceded my joining Yale in 2004.
My primary role at Yale is of diagnostic and research veterinary pathology as the Director of our Comparative Pathology Research Core https://medicine.yale.edu/compmed/mrp/. The research work I do is through working closely with post doctoral research fellows and graduate students, and researchers on their projects within and outside of Yale fee-for-service. Thus, I do not have my own research laboratory, nor do not take graduate students or post doctoral students directly.
Teaching and training people in rodent necropsy and blood collection are also part of my teaching role for the Department of Comparative Medicine.
My own research involves an external proejct collecting data on privately owned dogs.
Polyhydroallantois in Gravid Dogs: Ongoing 2016 - present
Genetics, pathology and physiology of excess extra fetal membrane fluid in pregnant dogs. Collaborative project with small animal veterinarians, dog breeders and team of experts within and outside of Yale.
Project Lead: Carmen J. Booth, DVM, PhD Department Comparative Medicine
Yale University, School of Medicine, New Haven CT 06510
WAG/RijYcb Hemophilia A rat model 2007 - archived at present.
Appointments
Comparative Medicine
Associate Professor on TermPrimary
Other Departments & Organizations
- All Institutions
- Comparative Medicine
- MORE
- Yale Ventures
Education & Training
- PhD
- University of Washington, Pathology (2005)
- Postdoctoral Fellow
- University of Washington (2003)
- Postdoctoral Fellow
- Harvard Medical School, New England Primate Research Center (1998)
- DVM
- University of California at Davis, School of Veterinary Medicine (1992)
- BS
- University of California at Davis, Animal Science Pre-Vet (1987)
- Non Degree Program
- California State Polytechnic University, Animal Science Pre-Vet (1984)
Research
Publications
2026
Hypomorphic Protein Expression of DNA Polymerase Beta in Polβ(L301R-V303R/L301R-V303R) Knock-In Transgenic Mice Does Not Impact Global DNA Methylation Levels in the Midbrain.
Jacobs B, Ivanov D, Barraza I, Faulk C, Booth CJ, Mattos-Canedo R, Tian L, DePietro K, Uzun A, Roos WP, Sanders LH, Sobol RW. Hypomorphic Protein Expression of DNA Polymerase Beta in Polβ(L301R-V303R/L301R-V303R) Knock-In Transgenic Mice Does Not Impact Global DNA Methylation Levels in the Midbrain. Biomolecules 2026, 16 PMID: 41897348, DOI: 10.3390/biom16030412.Peer-Reviewed Original ResearchForensic and neuropathological characteristics of lethal acute blunt traumatic spinal cord injury
Wachtler N, Roman K, Stuelpnagel J, Landi K, Storck K, Booth C, Faust B, Leelatian N, McGuone D. Forensic and neuropathological characteristics of lethal acute blunt traumatic spinal cord injury. Journal Of Forensic Sciences 2026 PMID: 41803054, DOI: 10.1111/1556-4029.70305.Peer-Reviewed Original ResearchTraumatic spinal cord injuryAcute traumatic spinal cord injuryMotor vehicle collisionsSpinal cord injuryCord injurySpinal injuryVehicle collisionsTrauma mechanismMechanism of injuryClinical registryAtlanto-axial dislocationInclusion criteriaStanding heightNew York City OfficeTrauma dataAcute spinal cord injuryMedical examinationSpinal diseaseChief Medical ExaminerPrevent neurological disordersYoung individualsAutopsy dataNeuropathological dataExtra-axial hemorrhageAutopsy recordsPeptidoglycan architecture dictates protein interactions, tissue tropism, and arthritis in the Lyme disease spirochete Borrelia burgdorferi
Ahmad S, Ebohon O, McClune M, Trimble R, Kellogg C, Booth C, Zückert W, Jutras B. Peptidoglycan architecture dictates protein interactions, tissue tropism, and arthritis in the Lyme disease spirochete Borrelia burgdorferi. PLOS Pathogens 2026, 22: e1013849. PMID: 41557633, PMCID: PMC12818604, DOI: 10.1371/journal.ppat.1013849.Peer-Reviewed Original ResearchConceptsCell envelopeTissue tropismLyme disease spirochete Borrelia burgdorferiLyme arthritisBacterial cell envelopeLyme disease pathogenesisPeriplasmic proteinsIsogenic deletionPeptidoglycan architectureMutant strainStem peptidesBacterial featuresProtein interactionsCellular phenotypesPeptidoglycanCell wallPG stem peptideSpirochete Borrelia burgdorferi
2025
Unique features of B. burgdorferi peptidoglycan drive persistence in discrete tissues and cause responses that mimic chronic illness 9279
McClune M, Ebohon O, Dressler J, Davis M, Tupik J, Lochhead R, Booth C, Steere A, Jutras B. Unique features of B. burgdorferi peptidoglycan drive persistence in discrete tissues and cause responses that mimic chronic illness 9279. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2702.Peer-Reviewed Original ResearchLyme arthritisDebilitating symptomsSymptoms of Lyme diseaseFungal immunologySynovial fluidPersistent antigenLA patientsBacterial clearanceLyme diseaseKupffer cellsImmune responseMetabolic dysregulationHost in vivoEnergy related pathwaysLyme disease symptomsVirulence factorsClearance ratePatientsMultiomics studiesBacterial componentsChronic illnessChronic fatigueClearanceLiverPost-infectionCD8 T cells mediate immunosurveillance for neoantigen+ epithelial stem cells in the colon.
Buck J, Iyer NR, Fagerberg E, Micevic G, He J, St Denis K, Shah V, Blackburn HN, Venkatesan S, Attanasio J, Hunt BG, Dalrymple A, Konnikova L, Beyaz S, Damo M, Booth CJ, Connolly KA, Joshi NS. CD8 T cells mediate immunosurveillance for neoantigen+ epithelial stem cells in the colon. BioRxiv 2025 PMID: 41280049, DOI: 10.1101/2025.10.19.683142.Peer-Reviewed Original ResearchThe peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness
McClune M, Ebohon O, Dressler J, Davis M, Tupik J, Lochhead R, Booth C, Steere A, Jutras B. The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness. Science Translational Medicine 2025, 17: eadr2955. PMID: 40267217, PMCID: PMC12207536, DOI: 10.1126/scitranslmed.adr2955.Peer-Reviewed Original ResearchConceptsAcute infectionPeripheral blood mononuclear cellsBlood mononuclear cellsMurine modelPostinfectious complicationsMononuclear cellsMinimal pathologyKupffer cellsPersistent symptomsLyme arthritisPublic health concernLiver occupationLiver accumulationInflamed jointsSecreted protein profileInfectionChronic illnessOrgan-specificPatientsSynovial fluidPathogenic molecules
2023
Adiponectin in the mammalian host influences ticks’ acquisition of the Lyme disease pathogen Borrelia
Tang X, Cao Y, Booth C, Arora G, Cui Y, Matias J, Fikrig E. Adiponectin in the mammalian host influences ticks’ acquisition of the Lyme disease pathogen Borrelia. PLOS Biology 2023, 21: e3002331. PMID: 37862360, PMCID: PMC10619873, DOI: 10.1371/journal.pbio.3002331.Peer-Reviewed Original ResearchConceptsAdipocyte-derived hormoneBite siteAdiponectin-deficient miceInfiltration of neutrophilsTick bite sitePro-inflammatory responseWild-type animalsIxodes scapularis ticksIL-1βVascular leakageHistamine releaseTick biteAdiponectinInfectious diseasesLyme disease agentBlood feeding arthropodsBorrelia burgdorferiScapularis ticksAnimal infectious diseasesBlood feedingB. burgdorferi survivalHuman bloodHormonePathogen acquisitionMammalian hostsHepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis
Mooring M, Yeung G, Luukkonen P, Liu S, Akbar M, Zhang G, Balogun O, Yu X, Mo R, Nejak-Bowen K, Poyurovsky M, Booth C, Konnikova L, Shulman G, Yimlamai D. Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis. Science Translational Medicine 2023, 15: eade3157. PMID: 37756381, PMCID: PMC10874639, DOI: 10.1126/scitranslmed.ade3157.Peer-Reviewed Original ResearchConceptsNonalcoholic steatohepatitisLiver inflammationNonalcoholic fatty liver diseaseProgression of NASHCysteine-rich angiogenic inducer 61Fatty liver diseaseLiver-specific knockout miceImproved glucose toleranceType 2 diabetesGlucose toleranceLiver diseaseNASH progressionProfibrotic macrophagesProinflammatory propertiesReduced fibrosisCardiovascular diseaseProfibrotic phenotypeFibrotic developmentKnockout miceNF-κBMetabolic diseasesNASH dietPDGFB expressionFibrosisProfibrotic programPolyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens
Fang Z, Monteiro V, Renauer P, Shang X, Suzuki K, Ling X, Bai M, Xiang Y, Levchenko A, Booth C, Lucas C, Chen S. Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens. Cell Research 2023, 33: 407-410. PMID: 36879038, PMCID: PMC9988199, DOI: 10.1038/s41422-023-00792-5.Peer-Reviewed Original ResearchRepeated Tick Infestations Impair Borrelia burgdorferi Transmission in a Non-Human Primate Model of Tick Feeding
Narasimhan S, Booth C, Philipp M, Fikrig E, Embers M. Repeated Tick Infestations Impair Borrelia burgdorferi Transmission in a Non-Human Primate Model of Tick Feeding. Pathogens 2023, 12: 132. PMID: 36678479, PMCID: PMC9861725, DOI: 10.3390/pathogens12010132.Peer-Reviewed Original ResearchNon-human primatesImmune responseLyme diseaseTick transmissionAnimal modelsGuinea pigsNon-human primate modelProtective immune responseTick feedingTick infestationRobust immune responseTick salivary antigensElicit immune responsesHuman Lyme diseaseClinical manifestationsHuman pathogensPrimate modelSalivary antigensNon-natural hostsVaccine targetsDiseaseVaccine discoveryTick resistanceBorreliaNatural host
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