Scientists find many gene 'drivers' of cancer, but warn: Don't ignore 'passengers'
A massive analysis of the entire genomes of 2,658 people with 38 different types of cancer has identified mutations in 179 genes and gene regulators as “drivers” — variations in DNA sequences that lead to the development of cancer.
In the right (lab) culture, mentorship flourishes — and science benefits
You might imagine a science lab looking a bit sterile and impersonal — little sunlight, masked figures in white coats pouring neon-colored liquid into beakers, all business. You might not expect to hear a science lab referred to as familial, where badminton tournaments, movie nights and barbeques are commonplace.
Colón-Ramos named McConnell Duberg Associate Professor
Daniel A. Colón-Ramos, PhD, recently appointed as Dorys McConnell Duberg Associate Professor of Neuroscience and Cell Biology, focuses his research on how synapses are formed and maintained to control behavior and store memories. Colón-Ramos’ discoveries have altered long-held views on the process and may offer important clues in the fight against disease.
Study Explores Role of Metabolism in Immune Cell Behavior
What makes healthy cells change and become dysfunctional to the point of causing disease? In addition to a disruption in genes that regulate cells, there is another factor in cell misbehavior that involves metabolism, say Yale researchers.
Protein-slaying Drugs Could Be the Next Blockbuster Therapies
A drug strategy called targeted protein degradation; and pursued by Craig Crews, PhD, Lewis B. Cullman Professor of Molecular, Cellular, and Developmental Biology, and professor of chemistry; capitalizes on the cell’s natural system for clearing unwanted or damaged proteins, and is in line to be used in promising clinical trials.Source: Nature
Of Worms and a Special Love of Home
Daniel Colón-Ramos works with the roundworm C. elegans as a means of advancing knowledge of the fundamental building blocks of the nervous system, saying that mastering the basics is essential to answering the bigger questions. He also has dedicated himself to improving opportunities for people in his native Puerto Rico.Source: Medicine@Yale
Ponce receives Paul Nelson Award from Council of Chairs of Training Councils
Allison Ponce, PhD, Associate Professor of Psychiatry, has received the Paul Nelson Award from the Council of Chairs of Training Councils (CCTC). CCTC is comprised of the presidents and chairs of the education and training associations in health service psychology with the mission of enhancing collaboration in psychology education.
Scientists find clues to mystery of Williams Syndrome’s peculiar symptoms
Patients with Williams Syndrome often are extremely social and possess a remarkable affinity and talent for music. They also experience life-threatening cardiovascular problems and developmental disabilities. The mystery is what happens during development to cause such peculiar symptoms.
Neuroscientists, Geneticist Win ‘High Risk, High Reward’ Grants
Three Yale researchers have won 2018 ‘High Risk, High Rewards’ grants from the Common Fund of the National Institutes of Health, which intends to fund “major opportunities and gaps in biomedical research that require trans-NIH collaboration to succeed.”