Rajiv Radhakrishnan, MBBS, MD, FAPA
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Appointments
Psychiatry
Primary
Radiology & Biomedical Imaging
Secondary
Titles
Assistant Professor, Radiology and Biomedical Imaging; Co-Medical Director, Yale PET Center; Affiliated Faculty, Yale Institute for Global Health
Contact Info
Appointments
Psychiatry
Primary
Radiology & Biomedical Imaging
Secondary
Titles
Assistant Professor, Radiology and Biomedical Imaging; Co-Medical Director, Yale PET Center; Affiliated Faculty, Yale Institute for Global Health
Contact Info
Appointments
Psychiatry
Primary
Radiology & Biomedical Imaging
Secondary
Titles
Assistant Professor, Radiology and Biomedical Imaging; Co-Medical Director, Yale PET Center; Affiliated Faculty, Yale Institute for Global Health
Contact Info
About
Titles
Assistant Professor of Psychiatry
Assistant Professor, Radiology and Biomedical Imaging; Co-Medical Director, Yale PET Center; Affiliated Faculty, Yale Institute for Global HealthAppointments
Psychiatry
Assistant ProfessorPrimaryRadiology & Biomedical Imaging
Assistant ProfessorSecondary
Other Departments & Organizations
- Center for Brain & Mind Health
- Interventional Psychiatry Service
- NeuroPET Imaging Program
- Positron Emission Tomography (PET)
- Psychiatry
- Radiology & Biomedical Imaging
- Yale Center for the Science of Cannabis and Cannabinoids
- Yale Institute for Global Health
- Yale Medicine
Education & Training
- MHS
- Yale University (2021)
- MD
- St. John's Medical College (2008)
- MBBS
- St John's Medical College, Medicine (2003)
Research
Overview
Medical Subject Headings (MeSH)
Marijuana Abuse; Psychoses, Substance-Induced; Schizophrenia
ORCID
0000-0002-8220-655X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Rajiv Radhakrishnan's published research.
Publications Timeline
A big-picture view of Rajiv Radhakrishnan's research output by year.
Research Interests
Research topics Rajiv Radhakrishnan is interested in exploring.
Deepak Cyril Dsouza, MBBS, MD
Nabeel Nabulsi, PhD
David Matuskey, MD
Irina Esterlis, PhD
Mika Naganawa, PhD
Richard Carson, PhD
25Publications
480Citations
Schizophrenia
Marijuana Abuse
Publications
2024
37. The Structural Connectome Constrains in Vivo Synaptic Density Loss in Schizophrenia
Chopra S, Worhunsky P, Naganawa M, Angarita G, Cosgrove K, D'Souza D, Matuskey D, Nabulsi N, Huang Y, Carson R, Esterlis I, Skosnik P, Holmes A, Radhakrishnan R. 37. The Structural Connectome Constrains in Vivo Synaptic Density Loss in Schizophrenia. Biological Psychiatry 2024, 95: s90. DOI: 10.1016/j.biopsych.2024.02.215.Peer-Reviewed Original ResearchSubstance use and spine density: a systematic review and meta-analysis of preclinical studies
Oliva H, Prudente T, Nunes E, Cosgrove K, Radhakrishnan R, Potenza M, Angarita G. Substance use and spine density: a systematic review and meta-analysis of preclinical studies. Molecular Psychiatry 2024, 1-13. PMID: 38561468, DOI: 10.1038/s41380-024-02519-3.Peer-Reviewed Original ResearchAltmetricConceptsSpine densityPrefrontal cortexSubstance useDrug self-administrationHippocampal spine densityEffects of cocaineSubstance use disordersConvergence of findingsSpine density changesSubstances of abuseMeta-analysis of preclinical studiesNucleus accumbensBehavioral sensitizationSelf-administrationBrain mechanismsPreclinical studiesBrain regionsMorphine effectsSynaptic density changesMeta-analysisAmphetamineSynaptic densityCocaineModerate-to-highCortexIn Vivo Synaptic Density in Early Schizophrenia: Are There No Differences or Are They Too Small to Detect?
Radhakrishnan R. In Vivo Synaptic Density in Early Schizophrenia: Are There No Differences or Are They Too Small to Detect? Biological Psychiatry 2024, 95: 605-607. PMID: 38479976, DOI: 10.1016/j.biopsych.2024.01.016.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSynaptic densityA systematic review of approaches to improve medication adherence in homeless adults with psychiatric disorders
Hird R, Radhakrishnan R, Tsai J. A systematic review of approaches to improve medication adherence in homeless adults with psychiatric disorders. Frontiers In Psychiatry 2024, 14: 1339801. PMID: 38260790, PMCID: PMC10800888, DOI: 10.3389/fpsyt.2023.1339801.Peer-Reviewed Original ResearchConceptsMedication adherenceAssertive community treatmentLong-Acting Injectable MedicationsPsychiatric disordersInjectable medicationsAdherence enhancementCommunity treatmentHomeless adultsSystematic reviewPsychiatric medication adherenceSubstance use disordersFull-text reviewModified therapeutic communityPeer-reviewed journalsInpatient interventionLarge RCTsSelf-designed scaleHomeless individualsOutpatient interventionInpatient carePharmacy clinicObservational studyInclusion criteriaUse disordersPeer-reviewed studies
2023
PET Biomarkers in Psychiatry
Orhii P, Radhakrishnan R, Selvaraj S. PET Biomarkers in Psychiatry. 2023, 81-104. DOI: 10.1007/978-3-031-43356-6_6.Peer-Reviewed Original ResearchThe regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J
Toyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot J, Matuskey D, Mecca A, Pittman B, Dias M, Nabulsi N, Finnema S, Chen M, Arnsten A, Radhakrishnan R, Skosnik P, D’Souza D, Esterlis I, Huang Y, van Dyck C, Carson R. The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 51: 1012-1022. PMID: 37955791, DOI: 10.1007/s00259-023-06487-8.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSynaptic densityAge-related decreaseMagnetic resonance imagingBlood flowAge-related synaptic lossGray matter volume lossSynaptic density lossPositron emission tomography (PET) ligandSynaptic vesicle glycoprotein 2AVivo PET measurementsMedial occipital cortexGray matter volumeAge-related neurodegenerationGray matter regionsCognitive normal subjectsAge-related changesSynaptic lossNerve terminalsWide age rangeOccipital cortexTomography ligandNormal subjectsGM volumeAge-related functional lossesMatter volumeSubstance Use Disorder and Health Outcomes in COVID-19—The Need for a Better Research Method to Determine Substance Use Exposure
Christian N, Zhou X, Radhakrishnan R. Substance Use Disorder and Health Outcomes in COVID-19—The Need for a Better Research Method to Determine Substance Use Exposure. JAMA Psychiatry 2023, 80: 968-968. PMID: 37405794, DOI: 10.1001/jamapsychiatry.2023.2113.Peer-Reviewed Original ResearchCitationsA leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
Jauhar S, Arnone D, Baldwin D, Bloomfield M, Browning M, Cleare A, Corlett P, Deakin J, Erritzoe D, Fu C, Fusar-Poli P, Goodwin G, Hayes J, Howard R, Howes O, Juruena M, Lam R, Lawrie S, McAllister-Williams H, Marwaha S, Matuskey D, McCutcheon R, Nutt D, Pariante C, Pillinger T, Radhakrishnan R, Rucker J, Selvaraj S, Stokes P, Upthegrove R, Yalin N, Yatham L, Young A, Zahn R, Cowen P. A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression. Molecular Psychiatry 2023, 28: 3149-3152. PMID: 37322065, PMCID: PMC10618084, DOI: 10.1038/s41380-023-02095-y.Peer-Reviewed Original ResearchCitationsAltmetricRole of Psychedelics in Treatment-Resistant Depression.
Kamal S, Jha MK, Radhakrishnan R. Role of Psychedelics in Treatment-Resistant Depression. Psychiatr Clin North Am 2023, 46: 291-305. PMID: 37149346, DOI: 10.1016/j.psc.2023.02.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsImpact of personal beliefs about medical cannabis on physician recommendation practices: Results of an international survey
Syed S, Singh J, Elkholy H, Rojnić Palavra I, Tomicevic M, Eric A, Pinto da Costa M, Guloksuz S, Radhakrishnan R. Impact of personal beliefs about medical cannabis on physician recommendation practices: Results of an international survey. Asian Journal Of Psychiatry 2023, 85: 103634. PMID: 37257363, DOI: 10.1016/j.ajp.2023.103634.Peer-Reviewed Original ResearchCitationsAltmetric
Clinical Trials
Current Trials
M1 Schizophrenia PET Study
HIC ID2000031171RolePrincipal InvestigatorPrimary Completion Date04/30/2023Recruiting ParticipantsGenderBothAge18 years - 55 yearsImaging cortisol metabolism in liver, adipose tissue and brain with a novel PET radioligand
HIC ID2000029576RoleSub InvestigatorPrimary Completion Date06/30/2024Recruiting ParticipantsTesting a Computationally-Informed, Personalized Intervention for Hallucinations
HIC ID2000024774RoleSub InvestigatorPrimary Completion Date03/31/2024Recruiting ParticipantsGenderBothAge18 years - 65 yearsA longitudinal study of the effects of cannabis exposure on neuro-development in adolescents and young adults
HIC ID2000024543RoleSub InvestigatorPrimary Completion Date01/31/2021Recruiting ParticipantsGenderBothAge13 years - 25 yearsSleep Dependent Learning in Schizophrenia and Psychosis Risk Syndrome
HIC ID1201009524RoleSub InvestigatorPrimary Completion Date01/31/2022Recruiting ParticipantsGenderBothAge18 years - 55 years
Academic Achievements and Community Involvement
activity Committee Member
Professional OrganizationsAmerican Society of Clinical Psychopharmacology (ASCP)Details05/01/2017 - Presentactivity Committee Member
Professional OrganizationsSchizophrenia International Research Society (SIRS)Details07/31/2019 - Presentactivity Member
CommitteesYale University Human Investigation Committee (HIC)Details09/01/2016 - Presentactivity Associate Editor
Journal ServiceJournal of Dual DiagnosisDetails09/11/2019 - Presentactivity Ad-hoc reviewer
Peer Review Groups and Grant Study SectionsMedical Research Council (MRC), UKDetails2019 - Present
Clinical Care
Overview
Clinical Specialties
Addiction Medicine
Board Certifications
Addiction Medicine (Preventive Medicine)
- Certification Organization
- AB of Preventive Medicine
- Original Certification Date
- 2020
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News
- April 02, 2024Source: Molecular Psychiatry
Substance Use and Spine Density: A Systematic Review and Meta-Analysis of Preclinical Studies
- December 18, 2022
Radhakrishnan Named Co-Medical Director of Yale PET Center
- August 30, 2022Source: The Journal of Clinical Psychiatry
Impact of Cannabis Use, Substance Use Disorders, and Psychiatric Diagnoses on COVID-19 Outcomes: A Retrospective Cohort Study
- December 12, 2021
Yale Study: Lower Prefrontal Cortical Synaptic Vesicle Binding in Cocaine Use Disorder