Mesenchymal stem cell-derived small extracellular vesicles alleviate the immunometabolic dysfunction in murine septic encephalopathy
Koutroulis I, Kratimenos P, Hoptay C, O’Brien W, Sanidas G, Byrd C, Triantafyllou M, Goldstein E, Jablonska B, Bharadwaj M, Gallo V, Freishtat R. Mesenchymal stem cell-derived small extracellular vesicles alleviate the immunometabolic dysfunction in murine septic encephalopathy. IScience 2024, 27: 110573. PMID: 39165840, PMCID: PMC11334791, DOI: 10.1016/j.isci.2024.110573.Peer-Reviewed Original ResearchCentral nervous systemSeptic encephalopathyStem cell (MSC)-derived small extracellular vesiclesSmall extracellular vesiclesDysregulated host response to infectionRestored aerobic metabolismLife-threatening organ dysfunctionLong-term sequelaeHost response to infectionExtracellular vesiclesMesenchymal stem cell-derived small extracellular vesiclesPro-inflammatory cytokinesCell-derived small extracellular vesiclesResponse to infectionStem cell-derived small extracellular vesiclesImmune dysregulationOrgan dysfunctionSusceptible to injurySeptic miceClinical symptomsClinical severityImmunometabolic dysfunctionIntravenous administrationDisease outcomeInfectious process