2025
Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis
Erickson M, Bansal S, Li C, Waltz J, Corlett P, Gold J. Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis. Biological Psychiatry Global Open Science 2025, 5: 100394. DOI: 10.1016/j.bpsgos.2024.100394.Peer-Reviewed Original ResearchHealthy comparison subjectsReduced mismatch negativityPrediction error signalsPositive symptomsMismatch negativityDeviant typesPredictive coding accountPresence of hallucinationsMismatch negativity paradigmAuditory memory tracesComparison subjectsCoding accountMemory tracesPsychiatric illnessMMN responseVoice hearersRepetitive positioningError signalDuration conditionsHallucinationsHigher-levelDMMNDifferent patternsSymptomsPSZ
2024
An Integrated theory of false insights and beliefs under psychedelics
McGovern H, Grimmer H, Doss M, Hutchinson B, Timmermann C, Lyon A, Corlett P, Laukkonen R. An Integrated theory of false insights and beliefs under psychedelics. Communications Psychology 2024, 2: 69. PMID: 39242747, PMCID: PMC11332244, DOI: 10.1038/s44271-024-00120-6.Peer-Reviewed Original ResearchLesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerceptionUnderstanding Cognitive Behavioral Therapy for Psychosis Through the Predictive Coding Framework
Sheffield J, Brinen A, Feola B, Heckers S, Corlett P. Understanding Cognitive Behavioral Therapy for Psychosis Through the Predictive Coding Framework. Biological Psychiatry Global Open Science 2024, 4: 100333. PMID: 38952435, PMCID: PMC11215207, DOI: 10.1016/j.bpsgos.2024.100333.Peer-Reviewed Original ResearchCognitive behavioral therapyPersecutory delusionsBehavioral therapyMaintenance of delusionsSymptoms of psychosisAssociative learning modelsCognitive-behavioral interventionsPrediction error signalsLevels of information processingPredictive coding frameworkHierarchical predictive codingPredictive codingPsychotic disordersPsychological treatmentCognitive neurosciencePsychological processesCBTpPsychosisDelusionsBelief updatingInformation processingAlternative beliefsNeuroscienceProcess theoryComputational neuroscienceBelief Updating, Childhood Maltreatment, and Paranoia in Schizophrenia-Spectrum Disorders
Sloan A, Kittleson A, Torregrossa L, Feola B, Rossi-Goldthorpe R, Corlett P, Sheffield J. Belief Updating, Childhood Maltreatment, and Paranoia in Schizophrenia-Spectrum Disorders. Schizophrenia Bulletin 2024, sbae057. PMID: 38701234, DOI: 10.1093/schbul/sbae057.Peer-Reviewed Original ResearchSchizophrenia spectrum disordersExposure to childhood maltreatmentPositive and Negative Syndrome ScaleChildhood Trauma QuestionnaireChildhood maltreatmentHierarchical Gaussian FilterBelief updatingProbabilistic reversal learningNegative Syndrome ScaleSyndrome ScaleNonpsychiatric controlsReversal learningSchizophrenia spectrumCumulative maltreatmentTrauma QuestionnaireDeprivation exposureGreen et al.ParanoiaConferring riskMaltreatmentPrior expectationsDisordersIndirect effectsChildhoodBeliefsLongitudinal Associations Between Belief Updating and Delusions in Individuals Recovering From an Acute Psychotic Episode
Sheffield J, Hall L, Vandekar S, Liu J, Woodward N, Heckers S, Corlett P. Longitudinal Associations Between Belief Updating and Delusions in Individuals Recovering From an Acute Psychotic Episode. Biological Psychiatry 2024, 95: s66-s67. DOI: 10.1016/j.biopsych.2024.02.164.Peer-Reviewed Original Research11. Role of Prediction Errors in the Relationship Between Ethnoracial Discrimination and Delusions
Huque Z, O'Brien K, Rossi-Goldthorpe R, Kenney J, Mittal V, Strauss G, Walker E, Schiffman J, Woods S, Powers A, Silverstein S, Waltz J, Gold J, Corlett P, Ellman L. 11. Role of Prediction Errors in the Relationship Between Ethnoracial Discrimination and Delusions. Biological Psychiatry 2024, 95: s78-s79. DOI: 10.1016/j.biopsych.2024.02.189.Peer-Reviewed Original ResearchDifferent learning aberrations relate to delusion-like beliefs with different contents
Rossi-Goldthorpe R, Silverstein S, Gold J, Schiffman J, Waltz J, Williams T, Powers A, Woods S, Zinbarg R, Mittal V, Ellman L, Strauss G, Walker E, Levin J, Castiello S, Kenney J, Corlett P. Different learning aberrations relate to delusion-like beliefs with different contents. Brain 2024, 147: 2854-2866. PMID: 38637303, PMCID: PMC11292907, DOI: 10.1093/brain/awae122.Peer-Reviewed Original ResearchProbabilistic reversal learningDelusion-like beliefsProbabilistic reversal learning taskBlocked cueControl cuesBelief convictionBlock taskClinical high-risk statusKamin blocking taskSymptom-specific effectsPrediction error accountLevels of paranoiaIntact learningAberrant learningKamin blockingParanoid individualsPersecutory delusionsCue presentationReversal learningPredicting psychosisCognitive tasksBehavioral resultsDecreased learningDelusionsParanoiaImagination, Agency, and Predictive Processing
Corlett P. Imagination, Agency, and Predictive Processing. 2024, 60-78. DOI: 10.1093/oso/9780198872221.003.0004.Peer-Reviewed Original ResearchPredictive processing theoryTheories of delusionsPredictive coding theorySensory inputDelusion formationSource monitoringProcess theoryDelusionsMediated learningHallucinationsConscious experienceImaginative processesReality perceptionPrediction processNeurocomputer architectureBeliefsPerceptionDysfunctionIllusory generalizability of clinical prediction models
Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.Peer-Reviewed Original ResearchDelusions and the Predictive Mind
Bongiorno F, Corlett P. Delusions and the Predictive Mind. Australasian Journal Of Philosophy 2024, 102: 1014-1029. DOI: 10.1080/00048402.2023.2293825.Peer-Reviewed Original Research
2023
Assessing the impact of a comprehensive mental health program on frontline health service workers
Ward E, Fragala M, Birse C, Hawrilenko M, Smolka C, Ambwani G, Brown M, Krystal J, Corlett P, Chekroud A. Assessing the impact of a comprehensive mental health program on frontline health service workers. PLOS ONE 2023, 18: e0294414. PMID: 37988363, PMCID: PMC10662717, DOI: 10.1371/journal.pone.0294414.Peer-Reviewed Original ResearchConceptsMental health benefitsSheehan Disability ScaleHealth service workersMental health issuesHealth benefitsHealth issuesRetrospective cohort studyPHQ-9 scaleMental health screeningComprehensive mental health programGAD-7 scaleMental health programsCare navigationCohort studyHealth screeningDisability ScaleMedication managementTreatment appointmentsFunctional impairmentLeast moderate anxietyHealth services companyOutcome assessmentHealth programsModerate anxietyAnxiety symptomsCognitive behavioral therapy following esketamine for major depression and suicidal ideation for relapse prevention: The CBT-ENDURE randomized clinical trial study protocol
Kitay B, Murphy E, Macaluso M, Corlett P, Hershenberg R, Joormann J, Martinez-Kaigi V, Nikayin S, Rhee T, Sanacora G, Shelton R, Thase M, Wilkinson S. Cognitive behavioral therapy following esketamine for major depression and suicidal ideation for relapse prevention: The CBT-ENDURE randomized clinical trial study protocol. Psychiatry Research 2023, 330: 115585. PMID: 37935086, DOI: 10.1016/j.psychres.2023.115585.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyMajor depressionSuicidal ideationRelapse preventionBehavioral therapyStudy protocolHigh riskClinical trial study protocolLong-term treatment approachKey secondary outcomesTrial study protocolHigh relapse rateHigh-risk populationSignificant suicidal ideationHospital dischargeSecondary outcomesPrimary outcomeRelapse rateFeasibility trialEsketamineTreatment approachesPatientsSuicide attemptsTherapySupplemental indicationsPsychedelics and the Neurobiology of Meaningfulness
Krystal J, Preller K, Corlett P, Anticevic A, Kaye A. Psychedelics and the Neurobiology of Meaningfulness. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 462-463. PMID: 37730161, DOI: 10.1016/j.bpsc.2023.09.003.Peer-Reviewed Original ResearchExcessive teleological thinking is driven by aberrant associations and not by failure of reasoning
Ongchoco J, Castiello S, Corlett P. Excessive teleological thinking is driven by aberrant associations and not by failure of reasoning. IScience 2023, 26: 107643. PMID: 37705957, PMCID: PMC10495659, DOI: 10.1016/j.isci.2023.107643.Peer-Reviewed Original ResearchAssociative learningTeleological thinkingCausal learning taskDelusion-like ideasFailure of reasoningCausal learningLearning taskLearningThinkingPrediction errorFundamental distinctionAberrant associationComputational modelingTeleological tendencyTaskReasoningTendencyDifferent instancesMeaningNew understandingObjectsDistinctionRelationshipEventsPhenomenological and Cognitive Features Associated With Auditory Hallucinations in Clinical and Nonclinical Voice Hearers
Gold J, Corlett P, Erickson M, Waltz J, August S, Dutterer J, Bansal S. Phenomenological and Cognitive Features Associated With Auditory Hallucinations in Clinical and Nonclinical Voice Hearers. Schizophrenia Bulletin 2023, 49: 1591-1601. PMID: 37350507, PMCID: PMC10686332, DOI: 10.1093/schbul/sbad083.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsVoice hearersUnusual beliefsExperience of AVHNegative symptomsDSM-V diagnosisFeatures of schizophreniaMotivational deficitsCognitive featuresBroad batteryVerbal hallucinationsDelusional beliefsSZ/schizoaffective disorderCognitive AssessmentLess distressSensory featuresCognitive deficitsFirst-rank symptomsBroader phenotypeAuditory hallucinationsCognitive impairmentSchizoaffective disorderSchizophreniaBeliefsDeficitsRelationships between cognitive biases, decision-making, and delusions
Sheffield J, Smith R, Suthaharan P, Leptourgos P, Corlett P. Relationships between cognitive biases, decision-making, and delusions. Scientific Reports 2023, 13: 9485. PMID: 37301915, PMCID: PMC10257713, DOI: 10.1038/s41598-023-36526-1.Peer-Reviewed Original ResearchConceptsDelusional ideationDelusional thinkingCognitive biasesDistinct cognitive processesSelf-reported dataCognitive processesProbabilistic reversalUnique varianceComputational mechanismsEvidence integrationPsychosis spectrumMultiple measuresProportion of varianceParanoiaRandom explorationIdeationThinkingTaskBiasesMeasuresVarianceDelusionsJTCIndependent studiesRelationshipThe association between evening social media use and delayed sleep may be causal: Suggestive evidence from 120 million Reddit timestamps
Meyerson W, Fineberg S, Andrade F, Corlett P, Gerstein M, Hoyle R. The association between evening social media use and delayed sleep may be causal: Suggestive evidence from 120 million Reddit timestamps. Sleep Medicine 2023, 107: 212-218. PMID: 37235891, DOI: 10.1016/j.sleep.2023.04.021.Peer-Reviewed Original ResearchConceptsSocial media useDelayed sleep onsetSelf-reported sleep patternsMedia useIndividual differencesDelayed sleepInsufficient sleepSleep onsetSleep patternsReddit usersSleepSocial media usageBedtimeSocial media usersAdditional supportOnset of sleepSocial mediaCausal effectMedia usageCausal relationshipPublic health officialsMedia usersPerceptionSuggestive evidenceRedditStudying Healthy Psychosislike Experiences to Improve Illness Prediction
Corlett P, Bansal S, Gold J. Studying Healthy Psychosislike Experiences to Improve Illness Prediction. JAMA Psychiatry 2023, 80: 515-517. PMID: 36884241, PMCID: PMC10848166, DOI: 10.1001/jamapsychiatry.2023.0059.Peer-Reviewed Original ResearchAssumed shared belief about conspiracy theories in social networks protects paranoid individuals against distress
Suthaharan P, Corlett P. Assumed shared belief about conspiracy theories in social networks protects paranoid individuals against distress. Scientific Reports 2023, 13: 6084. PMID: 37055504, PMCID: PMC10100615, DOI: 10.1038/s41598-023-33305-w.Peer-Reviewed Original ResearchConceptsConspiratorial beliefsConspiracy theoriesLess emotional distressIndividual-level processesParanoid individualsClinical paranoiaParanoid beliefsPsychological studiesConspiracy beliefsEmotional distressPersecutory delusionsBehavioral predictorsSocial supportBelief formationSocial accountsSocial networksOrganizational factorsParanoiaBroader social networksBeliefsLarge social networksSocietal normsDistressTaskLevel processes