2024
Illusory generalizability of clinical prediction models
Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.Peer-Reviewed Original Research
2023
Assessing the impact of a comprehensive mental health program on frontline health service workers
Ward E, Fragala M, Birse C, Hawrilenko M, Smolka C, Ambwani G, Brown M, Krystal J, Corlett P, Chekroud A. Assessing the impact of a comprehensive mental health program on frontline health service workers. PLOS ONE 2023, 18: e0294414. PMID: 37988363, PMCID: PMC10662717, DOI: 10.1371/journal.pone.0294414.Peer-Reviewed Original ResearchConceptsMental health benefitsSheehan Disability ScaleHealth service workersMental health issuesHealth benefitsHealth issuesRetrospective cohort studyPHQ-9 scaleMental health screeningComprehensive mental health programGAD-7 scaleMental health programsCare navigationCohort studyHealth screeningDisability ScaleMedication managementTreatment appointmentsFunctional impairmentLeast moderate anxietyHealth services companyOutcome assessmentHealth programsModerate anxietyAnxiety symptomsCognitive behavioral therapy following esketamine for major depression and suicidal ideation for relapse prevention: The CBT-ENDURE randomized clinical trial study protocol
Kitay B, Murphy E, Macaluso M, Corlett P, Hershenberg R, Joormann J, Martinez-Kaigi V, Nikayin S, Rhee T, Sanacora G, Shelton R, Thase M, Wilkinson S. Cognitive behavioral therapy following esketamine for major depression and suicidal ideation for relapse prevention: The CBT-ENDURE randomized clinical trial study protocol. Psychiatry Research 2023, 330: 115585. PMID: 37935086, DOI: 10.1016/j.psychres.2023.115585.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyMajor depressionSuicidal ideationRelapse preventionBehavioral therapyStudy protocolHigh riskClinical trial study protocolLong-term treatment approachKey secondary outcomesTrial study protocolHigh relapse rateHigh-risk populationSignificant suicidal ideationHospital dischargeSecondary outcomesPrimary outcomeRelapse rateFeasibility trialEsketamineTreatment approachesPatientsSuicide attemptsTherapySupplemental indicationsPhenomenological and Cognitive Features Associated With Auditory Hallucinations in Clinical and Nonclinical Voice Hearers
Gold J, Corlett P, Erickson M, Waltz J, August S, Dutterer J, Bansal S. Phenomenological and Cognitive Features Associated With Auditory Hallucinations in Clinical and Nonclinical Voice Hearers. Schizophrenia Bulletin 2023, 49: 1591-1601. PMID: 37350507, PMCID: PMC10686332, DOI: 10.1093/schbul/sbad083.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsVoice hearersUnusual beliefsExperience of AVHNegative symptomsDSM-V diagnosisFeatures of schizophreniaMotivational deficitsCognitive featuresBroad batteryVerbal hallucinationsDelusional beliefsSZ/schizoaffective disorderCognitive AssessmentLess distressSensory featuresCognitive deficitsFirst-rank symptomsBroader phenotypeAuditory hallucinationsCognitive impairmentSchizoaffective disorderSchizophreniaBeliefsDeficitsRelationships between cognitive biases, decision-making, and delusions
Sheffield J, Smith R, Suthaharan P, Leptourgos P, Corlett P. Relationships between cognitive biases, decision-making, and delusions. Scientific Reports 2023, 13: 9485. PMID: 37301915, PMCID: PMC10257713, DOI: 10.1038/s41598-023-36526-1.Peer-Reviewed Original ResearchConceptsDelusional ideationDelusional thinkingCognitive biasesDistinct cognitive processesSelf-reported dataCognitive processesProbabilistic reversalUnique varianceComputational mechanismsEvidence integrationPsychosis spectrumMultiple measuresProportion of varianceParanoiaRandom explorationIdeationThinkingTaskBiasesMeasuresVarianceDelusionsJTCIndependent studiesRelationshipThe association between evening social media use and delayed sleep may be causal: Suggestive evidence from 120 million Reddit timestamps
Meyerson W, Fineberg S, Andrade F, Corlett P, Gerstein M, Hoyle R. The association between evening social media use and delayed sleep may be causal: Suggestive evidence from 120 million Reddit timestamps. Sleep Medicine 2023, 107: 212-218. PMID: 37235891, DOI: 10.1016/j.sleep.2023.04.021.Peer-Reviewed Original ResearchConceptsSocial media useDelayed sleep onsetSelf-reported sleep patternsMedia useIndividual differencesDelayed sleepInsufficient sleepSleep onsetSleep patternsReddit usersSleepSocial media usageBedtimeSocial media usersAdditional supportOnset of sleepSocial mediaCausal effectMedia usageCausal relationshipPublic health officialsMedia usersPerceptionSuggestive evidenceRedditStudying Healthy Psychosislike Experiences to Improve Illness Prediction
Corlett P, Bansal S, Gold J. Studying Healthy Psychosislike Experiences to Improve Illness Prediction. JAMA Psychiatry 2023, 80: 515-517. PMID: 36884241, PMCID: PMC10848166, DOI: 10.1001/jamapsychiatry.2023.0059.Peer-Reviewed Original ResearchAssumed shared belief about conspiracy theories in social networks protects paranoid individuals against distress
Suthaharan P, Corlett P. Assumed shared belief about conspiracy theories in social networks protects paranoid individuals against distress. Scientific Reports 2023, 13: 6084. PMID: 37055504, PMCID: PMC10100615, DOI: 10.1038/s41598-023-33305-w.Peer-Reviewed Original ResearchConceptsConspiratorial beliefsConspiracy theoriesLess emotional distressIndividual-level processesParanoid individualsClinical paranoiaParanoid beliefsPsychological studiesConspiracy beliefsEmotional distressPersecutory delusionsBehavioral predictorsSocial supportBelief formationSocial accountsSocial networksOrganizational factorsParanoiaBroader social networksBeliefsLarge social networksSocietal normsDistressTaskLevel processesUsing dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis
Fleming L, Lemonde A, Benrimoh D, Gold J, Taylor J, Malla A, Joober R, Iyer S, Lepage M, Shah J, Corlett P. Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis. Scientific Reports 2023, 13: 4841. PMID: 36964175, PMCID: PMC10039017, DOI: 10.1038/s41598-023-31909-w.Peer-Reviewed Original ResearchConceptsHallucinations/delusionsFirst-episode psychosisFirst-episode psychosis participantsEarly intervention programsPathophysiological mechanismsUnderlying pathophysiologyEpisode psychosisPsychotic illnessPsychotic symptomsPsychotic disordersSchizoaffective disorderAuditory hallucinationsPositive symptomsHallucination severityNegative symptomsSymptomsDisorganization symptomsIntervention programsHallucinationsIllnessPsychosis participantsPsychosisDelusionsDisordersParticipantsSelf-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis
Karp E, Williams T, Ellman L, Strauss G, Walker E, Corlett P, Woods S, Powers A, Gold J, Schiffman J, Waltz J, Silverstein S, Mittal V. Self-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis. Schizophrenia Bulletin 2023, 49: 746-755. PMID: 36939086, PMCID: PMC10154698, DOI: 10.1093/schbul/sbac197.Peer-Reviewed Original ResearchConceptsClinical high riskGesture deficitsInternalizing disordersCHR groupGesture interpretationLower verbal learningViable assessment toolVerbal learningNeurocognitive tasksGeneral intelligencePerformance deficitsNonverbal behaviorProcessing speedCHR participantsSimilar deficitsGreater deficitsHigh riskClinical InterviewFull psychotic disorderDeficitsSpecific subdomainsSRGPPsychotic disordersPsychosisGesturesThe reliability and validity of the revised Green et al. paranoid thoughts scale in individuals at clinical high‐risk for psychosis
Williams T, Walker E, Strauss G, Woods S, Powers A, Corlett P, Schiffman J, Waltz J, Gold J, Silverstein S, Ellman L, Zinbarg R, Mittal V. The reliability and validity of the revised Green et al. paranoid thoughts scale in individuals at clinical high‐risk for psychosis. Acta Psychiatrica Scandinavica 2023, 147: 623-633. PMID: 36905387, PMCID: PMC10463775, DOI: 10.1111/acps.13545.Peer-Reviewed Original ResearchConceptsCHR individualsClinical controlFull psychosisHealthy controlsGeneral populationPsychosis symptomsCHR participantsPoor social functioningGreen Paranoid Thoughts ScalePsychosisGroup differencesSocial functioningConfirmatory factor analysisParanoid Thoughts ScaleInterview measuresSeverity continuumTwo-factor structureCritical populationSelf-report measuresPresent studyDiscriminant validityPsychometric indicesParanoid thoughtsIndividualsParticipantsLearning to Discern the Voices of Gods, Spirits, Tulpas, and the Dead
Luhrmann T, Alderson-Day B, Chen A, Corlett P, Deeley Q, Dupuis D, Lifshitz M, Moseley P, Peters E, Powell A, Powers A. Learning to Discern the Voices of Gods, Spirits, Tulpas, and the Dead. Schizophrenia Bulletin 2023, 49: s3-s12. PMID: 36840538, PMCID: PMC9959996, DOI: 10.1093/schbul/sbac005.Peer-Reviewed Original ResearchA pilot randomized controlled trial of ketamine in Borderline Personality Disorder
Fineberg S, Choi E, Shapiro-Thompson R, Dhaliwal K, Neustadter E, Sakheim M, Null K, Trujillo-Diaz D, Rondeau J, Pittaro G, Peters J, Corlett P, Krystal J. A pilot randomized controlled trial of ketamine in Borderline Personality Disorder. Neuropsychopharmacology 2023, 48: 991-999. PMID: 36804489, PMCID: PMC10209175, DOI: 10.1038/s41386-023-01540-4.Peer-Reviewed Original ResearchConceptsBorderline personality disorderSecondary outcome measuresOutcome measuresSocio-occupational functioningSuicidal ideationPilot studyTrial of ketaminePersonality disorderInfusion of ketaminePrimary outcome measureEffects of ketamineMidazolam groupAdverse eventsKetamine groupClinical benefitMood symptomsKetamineFDA approvalDrug midazolamInfusionBPD symptomsLarger studyDepressed moodSymptomsChronic mood
2022
Do psychedelics change beliefs?
McGovern H, Leptourgos P, Hutchinson B, Corlett P. Do psychedelics change beliefs? Psychopharmacology 2022, 239: 1809-1821. PMID: 35507071, DOI: 10.1007/s00213-022-06153-1.Peer-Reviewed Original ResearchHallucinogensHumans
2012
The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people
Corlett PR, Fletcher PC. The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people. Neuropsychologia 2012, 50: 3612-3620. PMID: 23079501, PMCID: PMC3694307, DOI: 10.1016/j.neuropsychologia.2012.09.045.Peer-Reviewed Original ResearchConceptsHealthy peopleSymptoms of psychosisPsychotic illnessEarly psychosisHealthy individualsPsychosis showHealthy beliefsAdditional alterationsNeural markersNeural responsesSymptomsPsychosisNovel evidenceDelusional ideationDistressSchizotypal experiencesAlterationsPatientsPrevious observationsIllnessNMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBrainCognitionDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleHumansInfusions, IntravenousKetamineMagnetic Resonance ImagingMaleMemoryModels, NeurologicalPattern Recognition, VisualPsychomotor PerformanceReceptors, N-Methyl-D-AspartateSchizophreniaSynaptic TransmissionYoung AdultConceptsNeural systemsLarge-scale brain systemsTask-dependent activationN-methyl-D-aspartate receptorsRealistic computational modelingSevere neuropsychiatric illnessNMDA glutamate receptor antagonistGlutamate receptor antagonistsBrain systemsNMDA receptor functionTask performanceMultiple interacting regionsCognitionCortical disinhibitionGlutamatergic neurotransmissionReceptor antagonistCortical computationGlutamate's roleReciprocal relationshipNeuropsychiatric illnessLocal circuitsReceptor functionSchizophreniaPresent findingsComputational modeling
2010
Glutamatergic Model Psychoses: Prediction Error, Learning, and Inference
Corlett PR, Honey GD, Krystal JH, Fletcher PC. Glutamatergic Model Psychoses: Prediction Error, Learning, and Inference. Neuropsychopharmacology 2010, 36: 294-315. PMID: 20861831, PMCID: PMC3055519, DOI: 10.1038/npp.2010.163.Peer-Reviewed Original ResearchToward a neurobiology of delusions
Corlett PR, Taylor JR, Wang X, Fletcher PC, Krystal JH. Toward a neurobiology of delusions. Progress In Neurobiology 2010, 92: 345-369. PMID: 20558235, PMCID: PMC3676875, DOI: 10.1016/j.pneurobio.2010.06.007.Peer-Reviewed Original ResearchConceptsFundamental brain mechanismsFronto-striatal circuitsTerms of cognitionPsychological processesBrain mechanismsComputational mechanismsCortical hierarchyPrediction errorSocial learningParietal cortexExternal worldBrain circuitsNeurobiological abnormalitiesNeurobiology of delusionsBrain functionHierarchical predictionBodily agencyDelusionsMemoryReinforcement learningPerceptionMental illnessTranslational understandingLearningCognition
2009
From drugs to deprivation: a Bayesian framework for understanding models of psychosis
Corlett PR, Frith CD, Fletcher PC. From drugs to deprivation: a Bayesian framework for understanding models of psychosis. Psychopharmacology 2009, 206: 515-530. PMID: 19475401, PMCID: PMC2755113, DOI: 10.1007/s00213-009-1561-0.Peer-Reviewed Original ResearchConceptsSymptoms of psychosisImportance of perceptionsProcessing of informationCognitive modelPrior expectanciesPerceptual AberrationModel of psychosisNeural circuitryInformation processingDifferent manipulationsPositive symptomsExperimental manipulationSerotonergic hallucinogensPerceptionPsychosisNew predictionsPsychotomimetic drugsUseful settingProcessingDistinctive effectsSymptomsInferenceNMDA receptor antagonistDistinct symptomsLearning
2007
Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
Corlett PR, Murray GK, Honey GD, Aitken MR, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC. Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions. Brain 2007, 130: 2387-2400. PMID: 17690132, PMCID: PMC3838942, DOI: 10.1093/brain/awm173.Peer-Reviewed Original ResearchConceptsDelusion formationDelusional beliefsPrediction error processingPrediction-error signallingPrediction error signalsAttentional allocationAssociative accountMaladaptive beliefsError processingAssociative learningNeurobiological theoriesBrain responsesCortex responsesIndividual's propensityBelief formationDelusionsBeliefsPrediction errorExtent of disruptionProcessingFMRILearningPsychosisExpectancyIndividuals