2012
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBrainCognitionDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleHumansInfusions, IntravenousKetamineMagnetic Resonance ImagingMaleMemoryModels, NeurologicalPattern Recognition, VisualPsychomotor PerformanceReceptors, N-Methyl-D-AspartateSchizophreniaSynaptic TransmissionYoung AdultConceptsNeural systemsLarge-scale brain systemsTask-dependent activationN-methyl-D-aspartate receptorsRealistic computational modelingSevere neuropsychiatric illnessNMDA glutamate receptor antagonistGlutamate receptor antagonistsBrain systemsNMDA receptor functionTask performanceMultiple interacting regionsCognitionCortical disinhibitionGlutamatergic neurotransmissionReceptor antagonistCortical computationGlutamate's roleReciprocal relationshipNeuropsychiatric illnessLocal circuitsReceptor functionSchizophreniaPresent findingsComputational modeling
2010
Toward a neurobiology of delusions
Corlett PR, Taylor JR, Wang X, Fletcher PC, Krystal JH. Toward a neurobiology of delusions. Progress In Neurobiology 2010, 92: 345-369. PMID: 20558235, PMCID: PMC3676875, DOI: 10.1016/j.pneurobio.2010.06.007.Peer-Reviewed Original ResearchConceptsFundamental brain mechanismsFronto-striatal circuitsTerms of cognitionPsychological processesBrain mechanismsComputational mechanismsCortical hierarchyPrediction errorSocial learningParietal cortexExternal worldBrain circuitsNeurobiological abnormalitiesNeurobiology of delusionsBrain functionHierarchical predictionBodily agencyDelusionsMemoryReinforcement learningPerceptionMental illnessTranslational understandingLearningCognition
2004
Prediction Error during Retrospective Revaluation of Causal Associations in HumansfMRI Evidence in Favor of an Associative Model of Learning
CORLETT P, AITKEN M, DICKINSON A, SHANKS D, HONEY G, HONEY R, ROBBINS T, BULLMORE E, FLETCHER P. Prediction Error during Retrospective Revaluation of Causal Associations in HumansfMRI Evidence in Favor of an Associative Model of Learning. Neuron 2004, 44: 877-888. DOI: 10.1016/s0896-6273(04)00756-1.Peer-Reviewed Original ResearchPrediction Error during Retrospective Revaluation of Causal Associations in Humans fMRI Evidence in Favor of an Associative Model of Learning
Corlett P, Aitken M, Dickinson A, Shanks D, Honey G, Honey R, Robbins T, Bullmore E, Fletcher P. Prediction Error during Retrospective Revaluation of Causal Associations in Humans fMRI Evidence in Favor of an Associative Model of Learning. Neuron 2004, 44: 877-888. PMID: 15572117, DOI: 10.1016/j.neuron.2004.11.022.Peer-Reviewed Original ResearchConceptsRetrospective revaluationPrefrontal cortexAssociative accountRight lateral PFC activationRight lateral prefrontal cortexLate brain responsesAssociative learning theoryLateral PFC activationLateral prefrontal cortexRight prefrontal cortexVentral striatal activationPrediction errorAssociative theoryPFC activationBrain responsesFunctional neuroimagingStriatal activationAssociative modelPC theoryAssociative viewLearning phenomenonLearning theoryContrast theoryLearningCuesOn the Benefits of not Trying: Brain Activity and Connectivity Reflecting the Interactions of Explicit and Implicit Sequence Learning
Fletcher P, Zafiris O, Frith C, Honey R, Corlett P, Zilles K, Fink G. On the Benefits of not Trying: Brain Activity and Connectivity Reflecting the Interactions of Explicit and Implicit Sequence Learning. Cerebral Cortex 2004, 15: 1002-1015. PMID: 15537672, PMCID: PMC3838938, DOI: 10.1093/cercor/bhh201.Peer-Reviewed Original ResearchConceptsImplicit learningFunctional magnetic resonance imaging studyExplicit memory processesExpression of learningRight frontal activationLearning-related changesMedial temporal lobeMagnetic resonance imaging studyImplicit sequenceResonance imaging studyBrain basisFrontal activationNeural basisMemory processesSequence difficultyMotor sequenceBrain activityBehavioral experimentsTemporal lobeBehavioral effectsLearningExplicit attemptSubjective intentionAutomatic learningImaging studies