2024
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerception
2018
Delusions and Prediction Error
Corlett P. Delusions and Prediction Error. 2018, 35-66. DOI: 10.1007/978-3-319-97202-2_2.Peer-Reviewed Original ResearchAberrant prediction errorsPrediction error responsesPrediction errorCognitive neuroscienceParsimonious accountNeural mechanismsError responsesProblem of beliefProminent theoriesPredictive codingNovel predictionsError accountsDelusionsBridging TheoryPhenomenological dataBeliefsAdaptive fitnessNeuroscienceSingle factorTheoryBrainMindErrorAccountPrediction