Childhood neglect is associated with alterations in neural prediction error signaling and the response to novelty.
Aloi J, Crum K, Blair K, Zhang R, Bashford-Largo J, Bajaj S, Hwang S, Averbeck B, Tottenham N, Dobbertin M, Blair R. Childhood neglect is associated with alterations in neural prediction error signaling and the response to novelty. Psychological Medicine 2024, 1-9. PMID: 39445510, DOI: 10.1017/s0033291724002411.Peer-Reviewed Original ResearchReward prediction errorEarly life stressLateral frontal cortexNovelty taskFrontal cortexNovel stimuliNeural prediction error signalsBlood oxygen level-dependent responsesAdolescents exposed to high levelsFunctional magnetic resonance imagingResponse to rewardChildhood Trauma QuestionnairePrediction error signalsLevel-dependent responsesAssociated with impairmentAssociation of abuseLevels of abuseReward responsivenessNeural differencesTrauma QuestionnaireChildhood neglectInstrumental learningLife stressBehavioral impairmentsMonetary rewards