2020
Hormonal Treatments for Major Depressive Disorder: State of the Art
Dwyer JB, Aftab A, Radhakrishnan R, Widge A, Rodriguez CI, Carpenter LL, Nemeroff CB, McDonald WM, Kalin NH. Hormonal Treatments for Major Depressive Disorder: State of the Art. American Journal Of Psychiatry 2020, 177: 686-705. PMID: 32456504, PMCID: PMC7841732, DOI: 10.1176/appi.ajp.2020.19080848.Peer-Reviewed Original ResearchConceptsHypothalamic pituitary thyroidMajor depressive disorderMajor depressionDepressive disorderEffective treatmentGlucocorticoid receptor antagonist mifepristoneCorticotropin-releasing factor antagonistProgesterone derivative allopregnanoloneEstrogen replacement therapyTreatment of depressionNovel effective treatmentsCommon psychiatric disordersMore effective treatmentsNumber of hormonesWorld Health OrganizationTraditional antidepressantsAdjunctive treatmentAntagonist mifepristoneCNS effectsReplacement therapyDisease burdenGonadal axesPreclinical studiesFactor antagonistsHormonal treatment
2011
Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats
Cao J, Dwyer JB, Mangold JE, Wang J, Wei J, Leslie FM, Li MD. Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats. The International Journal Of Neuropsychopharmacology 2011, 14: 157-174. PMID: 20196919, PMCID: PMC5575906, DOI: 10.1017/s1461145710000179.Peer-Reviewed Original ResearchConceptsGestational nicotine treatmentLimbic brain regionsCell adhesion moleculePsychiatric disordersBrain regionsPregnant Sprague-Dawley ratsGestational day 4Prenatal nicotine exposureNicotine replacement therapyPostnatal day 35Sprague-Dawley ratsMajor psychoactive componentAdolescent female ratsCentral nervous systemQuantitative RT-PCR techniqueRT-PCR techniqueMaternal smokingNicotine treatmentNicotine exposureReplacement therapyCaudate putamenFemale ratsPrenatal treatmentNeurotransmitter systemsNeurobehavioural deficits
2009
The dynamic effects of nicotine on the developing brain
Dwyer JB, McQuown SC, Leslie FM. The dynamic effects of nicotine on the developing brain. Pharmacology & Therapeutics 2009, 122: 125-139. PMID: 19268688, PMCID: PMC2746456, DOI: 10.1016/j.pharmthera.2009.02.003.Peer-Reviewed Original ResearchConceptsNicotine exposureDevelopmental influencesAdolescent periodBrain maturationExogenous nicotineHuman brainUnique effectsMaturational periodNeural structuresLimbic systemClinical literatureNicotine replacement therapyEnvironmental stimuliEarly postnatal periodPreclinical animal modelsDevelopmental windowNicotinic acetylcholine receptorsPrenatal periodReplacement therapyEarly postnatalPostnatal periodTobacco smokeAnimal modelsAcetylcholine receptorsNicotine
2008
Nicotine and brain development
Dwyer JB, Broide RS, Leslie FM. Nicotine and brain development. Birth Defects Research Part C Embryo Today Reviews 2008, 84: 30-44. PMID: 18383130, DOI: 10.1002/bdrc.20118.Peer-Reviewed Original ResearchConceptsNicotine replacement therapyMaternal smokingPharmacologic propertiesBrain developmentSudden infant death syndromeFetal central nervous systemAuditory cognitive dysfunctionActivation of nAChRsInfant death syndromeCentral nervous systemNumerous brain regionsNicotinic acetylcholine receptorsCell survivalLigand-gated ion channelsLong-term alterationsSpecific neural circuitryCritical developmental periodPregnant womenReplacement therapyTobacco cessationCholinergic modulationFunctional statusNeonatal brainPreclinical studiesTransmitter release