2009
Fgfr1 Is Required for Cortical Regeneration and Repair after Perinatal Hypoxia
Fagel DM, Ganat Y, Cheng E, Silbereis J, Ohkubo Y, Ment LR, Vaccarino FM. Fgfr1 Is Required for Cortical Regeneration and Repair after Perinatal Hypoxia. Journal Of Neuroscience 2009, 29: 1202-1211. PMID: 19176828, PMCID: PMC2768410, DOI: 10.1523/jneurosci.4516-08.2009.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnimalsAnimals, NewbornBromodeoxyuridineCell ProliferationCerebral CortexCreatinineDNA-Binding ProteinsGlial Fibrillary Acidic ProteinHypoxiaMiceMice, Inbred C57BLMice, TransgenicNerve RegenerationNeurogenesisNeuronsOlfactory BulbParvalbuminsPhosphopyruvate HydrataseReceptor, Fibroblast Growth Factor, Type 1T-Box Domain ProteinsConceptsWild-type miceCortical neuronsOlfactory bulbSubventricular zoneChronic postnatal hypoxiaNeonatal hypoxic injuryPersistent behavioral deficitsExcitatory cortical neuronsSVZ cell proliferationCell proliferationPostnatal day 3Receptor 1 geneNormoxic miceOB neurogenesisReactive neurogenesisPerinatal hypoxiaPostnatal hypoxiaNeuronal recoveryFibroblast growth factor receptor 1 (FGFR1) geneHypoxic miceChronic hypoxiaGABAergic interneuronsHypoxic injuryResidual deficitsCortical regeneration
2006
Early Postnatal Astroglial Cells Produce Multilineage Precursors and Neural Stem Cells In Vivo
Ganat YM, Silbereis J, Cave C, Ngu H, Anderson GM, Ohkubo Y, Ment LR, Vaccarino FM. Early Postnatal Astroglial Cells Produce Multilineage Precursors and Neural Stem Cells In Vivo. Journal Of Neuroscience 2006, 26: 8609-8621. PMID: 16914687, PMCID: PMC6674357, DOI: 10.1523/jneurosci.2532-06.2006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAstrocytesBrainCell DifferentiationCell LineageCerebral VentriclesDoublecortin ProteinFemaleGlial Fibrillary Acidic ProteinHumansIntegrasesMaleMiceMice, TransgenicNeuronsOlfactory BulbOligodendrogliaPromoter Regions, GeneticRecombination, GeneticStem CellsTransgenesConceptsDentate gyrusHuman GFAP promoterCerebral cortexAstroglial cellsSubventricular zoneOlfactory bulbPostnatal brainNeural progenitor/stem cellsPostnatal day 5First postnatal weekProgenitor/stem cellsStem cellsInducible Cre recombinaseNeural stem cellsGenetic fate mappingMature neuronsPostnatal weekCNS regionsWhite matterDay 5GFAP promoterNeural precursorsCortexNeuronsCre recombinase
2004
Fibroblast Growth Factor 2 Is Required for Maintaining the Neural Stem Cell Pool in the Mouse Brain Subventricular Zone
Zheng W, Nowakowski RS, Vaccarino FM. Fibroblast Growth Factor 2 Is Required for Maintaining the Neural Stem Cell Pool in the Mouse Brain Subventricular Zone. Developmental Neuroscience 2004, 26: 181-196. PMID: 15711059, DOI: 10.1159/000082136.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersBrainCell Cycle ProteinsCell DifferentiationCell DivisionCell LineageCell ProliferationCerebral CortexDown-RegulationImmunohistochemistryLateral VentriclesMiceMice, KnockoutNeurogliaNeuronsOlfactory BulbReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 2Receptors, Fibroblast Growth FactorStem CellsConceptsStem cell poolNeural stem cellsFgf2 knockout miceSlower cell cycle kineticsProgenitor cell populationsSubventricular zoneCell poolNeural stem cell poolGene productsProgenitor populationsFibroblast growth factor-2Olfactory bulbKnockout miceCell cycleOlfactory bulb neurogenesisMolecular markersSmaller olfactory bulbsGrowth factor 2Brain subventricular zoneAnterior subventricular zoneReceptor proteinGlial fibrillary acidic proteinCell cycle kineticsStem cellsFibrillary acidic protein