2015
Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1+/− patients and in foxg1+/− mice
Patriarchi T, Amabile S, Frullanti E, Landucci E, Lo Rizzo C, Ariani F, Costa M, Olimpico F, W Hell J, M Vaccarino F, Renieri A, Meloni I. Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1+/− patients and in foxg1+/− mice. European Journal Of Human Genetics 2015, 24: 871-880. PMID: 26443267, PMCID: PMC4820038, DOI: 10.1038/ejhg.2015.216.Peer-Reviewed Original ResearchConceptsRett syndromeSynaptic markersInhibitory synapsesExcitatory/inhibitory balanceSynaptic protein expressionFetal mouse brainInhibitory synaptic markersPathogenesis of RTTExcitatory synaptic markersSevere neurodevelopmental disorderGlutamatergic markersInhibitory balanceAdult brainAdult micePrecise molecular mechanismsSynaptic differentiationPatientsMouse brainBrain synapsesPathological eventsNeuronsProtein expressionBrainGluD1Neurodevelopmental disorders
1994
Excitatory amino acid receptors in glial progenitor cells: Molecular and functional properties
Gallo V, Patneau D, Mayer M, Vaccarino F. Excitatory amino acid receptors in glial progenitor cells: Molecular and functional properties. Glia 1994, 11: 94-101. PMID: 7927651, DOI: 10.1002/glia.440110204.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsCells, CulturedCerebral CortexDNA-Binding ProteinsEarly Growth Response Protein 1Gene Expression RegulationGenes, Immediate-EarlyGlutamic AcidImmediate-Early ProteinsKainic AcidMembrane PotentialsN-MethylaspartateNerve Tissue ProteinsNeurotoxinsOligodendrogliaRatsReceptors, GlutamateStem CellsTranscription FactorsConceptsCG-4 cellsAMPA receptor antagonist CNQXWhole-cell patch-clamp recordingsExcitatory amino acid receptorsProgenitor cellsAmino acid receptorsRat cerebral cortexPatch-clamp recordingsGlial progenitor cellsGlutamate receptor subunitsAgonists L-glutamateGlutamate-gated channelsImmediate early gene NGFIAntagonist CNQXCerebral cortexGABA antibodyPrimary cell linesGlutamate receptorsTransient elevationAcid receptorsReceptor subunitsOligodendrocyte lineageOligodendrocyte progenitorsL-glutamateKainate
1988
Glutamate receptors, protein kinase C translocation, and gangliosides.
Vaccarino FM. Glutamate receptors, protein kinase C translocation, and gangliosides. Psychopharmacology Bulletin 1988, 24: 403-7. PMID: 2856417.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1987
Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons.
Vaccarino F, Guidotti A, Costa E. Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1987, 84: 8707-8711. PMID: 2825205, PMCID: PMC299615, DOI: 10.1073/pnas.84.23.8707.Peer-Reviewed Original ResearchConceptsGranule cellsProtein kinase C translocationExcitatory amino acid neurotransmitter receptorsAmino acid neurotransmitter receptorsPrimary culturesGlutamate-mediated Ca2Cerebellar granule cellsHigh affinity recognition sitesPKC translocationNeurotransmitter receptorsRemoval of Ca2Cerebellar neuronsActivation of PKCC translocationNeuronal membranesGanglioside inhibitionRedistribution of PKCIncubation mediumGlutamateCa2PKCActivation