2004
Loss of Glutamatergic Pyramidal Neurons in Frontal and Temporal Cortex Resulting from Attenuation of FGFR1 Signaling Is Associated with Spontaneous Hyperactivity in Mice
Shin DM, Korada S, Raballo R, Shashikant CS, Simeone A, Taylor JR, Vaccarino F. Loss of Glutamatergic Pyramidal Neurons in Frontal and Temporal Cortex Resulting from Attenuation of FGFR1 Signaling Is Associated with Spontaneous Hyperactivity in Mice. Journal Of Neuroscience 2004, 24: 2247-2258. PMID: 14999075, PMCID: PMC6730438, DOI: 10.1523/jneurosci.5285-03.2004.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AgonistsAmphetamineAnimalsCell DifferentiationCell DivisionFrontal LobeGlutamic AcidGuanfacineHumansHyperkinesisMiceMice, TransgenicNervous System MalformationsNeural InhibitionPyramidal CellsReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptors, Adrenergic, alpha-2Receptors, Fibroblast Growth FactorSignal TransductionStereotypic Movement DisorderTemporal LobeConceptsPyramidal neuronsCortical developmentTemporal areaSubcortical monoaminergic systemsGlutamatergic pyramidal neuronsCajal-Retzius cellsCortical GABAergic interneuronsCerebral cortical developmentAdrenergic receptor agonistEmbryonic neural progenitor cellsTemporal cortical areasReceptor gene productsNeural progenitor cellsEmbryonic brain developmentLocomotor hyperactivityRadial glia fibersCerebral cortexGlutamatergic neuronsBasal gangliaGABAergic interneuronsMonoaminergic systemsCortical plateReceptor agonistSpontaneous hyperactivityCortical areas
2002
Fibroblast Growth Factor 2 Is Necessary for the Growth of Glutamate Projection Neurons in the Anterior Neocortex
Korada S, Zheng W, Basilico C, Schwartz ML, Vaccarino FM. Fibroblast Growth Factor 2 Is Necessary for the Growth of Glutamate Projection Neurons in the Anterior Neocortex. Journal Of Neuroscience 2002, 22: 863-875. PMID: 11826116, PMCID: PMC6758485, DOI: 10.1523/jneurosci.22-03-00863.2002.Peer-Reviewed Original ResearchConceptsCerebral cortexParietal cortexAnterior cerebral cortexGlutamatergic pyramidal neuronsGABA receptor agonistsGlutamatergic neuronal populationsDuration of sleepAnterior cortical regionsBasic fibroblast growth factorCell numberNull mutant miceGranule cell numberFibroblast growth factor-2Fibroblast growth factorGABA interneuronsGrowth factor 2Fgf2-/- micePyramidal neuronsInhibitory neurotransmissionProjection neuronsAnterior neocortexReceptor agonistPyramidal cellsOccipital cortexNeuronal populations