Cerebellar Purkinje cell activity regulates white matter response and locomotor function after neonatal hypoxia.
Kratimenos P, Kundu S, Ghaemmaghami J, Sanidas G, Wolff N, Vij A, Byrd C, Simonti G, Triantafyllou M, Jablonska B, Dean T, Koutroulis I, Gallo V. Cerebellar Purkinje cell activity regulates white matter response and locomotor function after neonatal hypoxia. Journal Of Neuroscience 2024, e0899242024. PMID: 39472064, DOI: 10.1523/jneurosci.0899-24.2024.Peer-Reviewed Original ResearchWhite matter injuryNeonatal hypoxiaLocomotor deficitsPurkinje cellsWM injuryOligodendrocyte maturationCerebellar Purkinje cell activityNeuronal activitySurvivors of prematurityPC activityWhite matterTrimester of pregnancyCerebellar Purkinje cellsPurkinje cell activityRestoring neuronal activityLocomotor dysfunctionMultielectrode array recordingsHx miceOligodendrocyte precursor cellsPreterm neonatesPotential therapeutic interventionsNeonatal injuryGABAergic interneuronsCerebellar WMEffect of HX