Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors
Dixon R, Malave L, Thompson R, Wu S, Li Y, Sadik N, Anacker C. Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors. Neuropsychopharmacology 2024, 1-12. PMID: 39396089, DOI: 10.1038/s41386-024-01999-9.Peer-Reviewed Original ResearchEffects of early life adversityEarly life adversityVentral dentate gyrusAcute swim stressCorticotropin-releasing factorStress reactivityParaventricular nucleusSwim stressLife adversityNeuronal activityModel of early life adversityEarly life adversity effectsIn adulthoodIncreased passive copingSex-specific impairmentsFemale miceSerotonin-1ASerotonin systemNeurobiological mechanismsStress vulnerabilityIncreased microglia activationLimited beddingPassive copingAutoreceptorsCorticosterone levels