Postdoctoral Position Available in Braddock Lab
The Yale School of Medicine, Department of Pathology, is seeking a highly motivated postdoctoral associate to work in the Braddock lab, which investigates severe unmet medical illness through the study of Rare Diseases with a focus on dysregulated mineralization of the vasculature and the skeleton.
A Newfound Place of Pride for Pathology Labs
Scientists at Yale’s Molecular Diagnostics Lab, part of the Department of Pathology, rose to the challenge of the COVID-19 pandemic. In March 2020, the pathologists had none of the equipment or space necessary and far too few technicians qualified to process COVID-19 tests. By December 2020, they had the capacity to run an estimated 1,200 tests a day. Over the course of the pandemic, the Molecular Diagnostics Lab evolved from manually processing nasopharyngeal swabs to playing a crucial role in the validation and execution of Yale’s own FDA-approved SalivaDirect test.
Study Examines Severe Breakthrough Cases of COVID-19
These patients tended to be older—between 65 and 95 with a median age of 80.5—and had preexisting comorbidities, such as cardiovascular disease and type 2 diabetes. A subset of patients was also on immunosuppressive drugs that may affect vaccine efficacy.Source: YaleNews
Yale Scientists Reveal Molecular Pathway for Smarter Breast Cancer Drugs
New research at Yale has revealed major differences in aggressive types of breast cancer, and the potential for smarter treatments for patients. Triple-negative breast cancer, which has a low survival rate and a lack of helpful molecular biomarkers — specific proteins that signal the presence of disease — is among the most aggressive breast cancer subtypes.Source: Yale West Campus News
Lakshmanan Krishnamurti Named Chief of Pediatric Hematology, Oncology, and Bone Marrow Transplant at Yale New Haven Children’s Hospital and Smilow Cancer Hospital
Lakshmanan Krishnamurti, MD, has been named Chief of Pediatric Hematology, Oncology, and Bone Marrow Transplant at Yale New Haven Children’s Hospital and Leader of the Smilow Cancer Hospital Pediatric Hematology/Oncology Program.
How to spot poison oak and the rash it causes
Poison oak is a shrub that grows on the west coast and southeast region of North America. These poisonous plants have leaves that usually: Grow in groups of three Have rounded or wavy edges Are green Have fuzzy undersides that are usually a lighter color than the top Sometimes, there might be a visible black substance, called urushiol, on the leaves or stems. This is the same compound found in other poisonous plants like poison ivy and is responsible for causing a rash in most people. A rash from poison oak will appear pink, red, or less commonly, black. In more severe cases, you might also see blisters, says Christine Ko, MD, PhD, Yale Medicine dermatologist, dermatopathologist, and professor at Yale School of Medicine. RELATED How to tell if you have a poison oak rash and how to treat it Not everyone will develop a rash from poison oak. It's estimated that about 85% of people are allergic to urushiol and will get a rash on contact, and the rest will not.Source: Insider
The Understanding of Immunotherapy Biomarkers is Rapidly Evolving in Oncology
The landscape of immunotherapy biomarkers is rapidly evolving, and future developments are likely to have an impact on patients and clinicians alike, said Kurt A. Schalper, MD, PhD, in a virtual presentation during the 5th Annual International Congress on Oncology and Pathology.Source: OncLive
Yale Cancer Center Laboratory Study Shows Combination Treatment Effective in IDH Mutant Cancers
A new study led by Yale Cancer Center scientists revealed the combination of ATR and PARP inhibitor therapies can effectively target the enzyme isocitrate dehydrogenase-I/2 (IDH-1/2) in mutant cancer cells.
Dr. Nassiri is selected to the International Society for Study of Vascular Anomalies (ISSVA) task force on classification of vascular anomalies
Dr. Nassiri is selected to represent the United States and the Specialty of Vascular Surgery on the International Society for Study of Vascular Anomalies (ISSVA) Ad-hoc Committee for Classification of Vascular Anomalies.Source: ISSVA Newsletter Vol 5 - No 1 | April 2021
Markers in blood predict severe COVID-19 infection
When attempting to predict who will end up in the ICU with COVID-19, the answer flows in the blood. Until now, there was no definitive way to chart a patient’s course, but there are known risk factors, like obesity, high blood pressure and diabetes.Source: WGNTV
Mining Brain Metastasis for Answers
When lung cancer and breast cancer relapse, they often metastasize in the brain. The tumors that arise in the brain develop novel characteristics, differences that oft en confer resistance to existing drug therapies and create opportunities for new detection and treatment approaches for Yale Cancer Center researchers.
Rallying Resources Around DNA Repair Research
When it comes to unlocking the secrets of DNA repair, Yale Cancer Center has an armamentarium at work. In the last two years, Yale’s team has made significant advances in targeting the BRCA-dependent DNA repair axis for cancer therapy and determined that both BRCA1 and BRCA2 protein are involved in DNA repair, but they have fundamentally different mechanisms.