Markers in blood predict severe COVID-19 infection
When attempting to predict who will end up in the ICU with COVID-19, the answer flows in the blood. Until now, there was no definitive way to chart a patient’s course, but there are known risk factors, like obesity, high blood pressure and diabetes.Source: WGNTV
Mining Brain Metastasis for Answers
When lung cancer and breast cancer relapse, they often metastasize in the brain. The tumors that arise in the brain develop novel characteristics, differences that oft en confer resistance to existing drug therapies and create opportunities for new detection and treatment approaches for Yale Cancer Center researchers.
Rallying Resources Around DNA Repair Research
When it comes to unlocking the secrets of DNA repair, Yale Cancer Center has an armamentarium at work. In the last two years, Yale’s team has made significant advances in targeting the BRCA-dependent DNA repair axis for cancer therapy and determined that both BRCA1 and BRCA2 protein are involved in DNA repair, but they have fundamentally different mechanisms.
Winners Announced for Annual Yale Cancer Center Conclave Awards
Yale Cancer Center held its annual Conclave award ceremony virtually on January 26th to celebrate faculty and provider accomplishments 2020. Faculty and staff were honored with clinical and research prizes including the Ruth McCorkle Oncology Advanced Practice Provider Award, the Class of ‘61 Cancer Research Award, and the Yale Cancer Center Lifetime Achievement Award.
'Cellular Chatter': Researchers Aim to Decode Communications Within a Tumor
Inside a tumor, chatter abounds. Multiple cell types are constantly communicating with each other, exchanging various types of information. Some are working together against the tumor, while others help the tumor grow. Researchers have a good handle on who the main players are, but it can be difficult to tell the good ones from the bad ones, and who’s communicating with whom. To make things even more complicated, sometimes good cells turn bad — and researchers don’t know why.
Yale Researchers Take Stem Cells One Step Closer to Replacing Parathyroid Gland Function
Yale investigators have developed a multistep process that models the biological instructions to create parathyroid gland cells from pluripotent stem cells, a significant milestone along the path toward helping people who lack the hormones released by parathyroid glands.
$15M NIDA Grant Awarded to Serena Spudich, Mark Gerstein, and Yuval Kluger
Principal Investigators Serena Spudich, MD, MA (Neurology), Mark Gerstein, PhD (Molecular Biophysics and Biochemistry), and Yuval Kluger, PhD (Pathology) were recently awarded a $15 million grant from the National Institute on Drug Abuse (NIDA) to establish a Data Center to coordinate, analyze, and make accessible single-cell and other molecular data sets generated by Single-Cell Opioid Responses in the Context of HIV (SCORCH) and other NIDA-funded HIV and substance use disorder projects.
An Innovative Treatment Approach for DIPG: CureSearch for Children’s Cancer Partners with SebastianStrong Foundation to Fund Promising New Research
CureSearch for Children’s Cancer, in partnership with the SebastianStrong Foundation, has awarded a $225,000 Young Investigator grant to Yale Cancer Center’s Dr. Ranjithmenon Muraleedharan, who will develop a new treatment approach for diffuse intrinsic pontine glioma (DIPG) – a devastating brain cancer with a 5-year survival rate of less than 1%. The 3-year project is funded by SebastianStrong Foundation’s Discovery Science Award.Source: CureSearch for Children's Cancer
A Call for More COVID-19 Vaccine Funding, and Praise for Yale's Achievements
On July 24, United States Senator Richard Blumenthal (D-CT) highlighted research conducted at Yale School of Medicine and urged his Senate colleagues to approve more federal funding for development and distribution of vaccines to halt the COVID-19 pandemic.
Yale Pathology Professor Receives NIH Award for Breakthrough Cancer Research
The award — granted to just 5% of NIH-funded investigators —ensures that Kurt Schalper’s research will be funded for the next seven years. It supports his groundbreaking work identifying novel pathways for cancer immunotherapy which can be used to optimally select and treat patients with non-small cell lung cancer.Source: YaleNews
Covid-19 Blood Clotting Cause Identified in Study Led by Yale Cancer Center Researchers
New findings led by Yale Cancer Center researchers and experts across several medical specialties at Yale identify a leading mechanism behind the pathophysiology of Covid-19 and pinpoint a biological marker for the mechanism that may aid in treating these patients.