Study illuminates tiny RNA’s role in heart disease, obesity
A tiny RNA molecule plays a big role in the development of two diseases affecting billions of people worldwide: heart disease and obesity. Yale researchers have found that by disrupting this microRNA in key tissues, they can reduce plaque buildup in arteries while avoiding unintended effects.
Yale lab finding may protect the heart during ischemia
Research from three Yale laboratories — in the fields of immunobiology, chemistry, and cardiology — could lead to new drugs to reduce complications during cardiac surgery or heart attacks. If they pan out in human trials, the drugs would limit the detrimental impact of ischemia—restriction of blood flow—thereby cutting the degree of damage to the heart. The research appeared in the June online issue of Circulation.
Strategies to accelerate diagnosis and treatment of rare cardiovascular diseases
The current landscape for patients with rare cardiovascular disease has shifted. Using genome sequencing Yale physician-scientists have begun to elucidate the pathophysiology of genetic disorders and develop treatment guidelines and recommendations.
Meta-analysis points to “inverse” relationship between TAVI centre volume and outcomes
The authors of a systematic review and meta-analysis, looking at the effect of institutional transcatheter aortic valve implantation (TAVI) volume on mortality, have concluded that more focus is needed on “strong referral networks and consolidation” rather than expansion of existing TAVI centers.Source: Cardiovascular News
AHA Journal Raises the Bar for Health Disparities Research
As part of efforts by the American Heart Association to combat structural racism, one of its scientific journals outlined best practices when conducting and submitting research on racial and ethnic health disparities.Source: MedPage Today