HER2 Low Breast Cancer: New Clinical Entity or Testing Artifact
Should breast cancer patients with low but not negative tumor expression of HER2 be considered a distinct patient group that can be treated differently from patients with tumors that are HER2 negative or HER2 positive? That was the question posed during a session at the recent San Antonio Breast Cancer Symposium (SABCS) 2022.Source: Medscape
Emerging Treatment Options in the Management of Resistance to Tyrosine Kinase Inhibitors in Non–Small Cell Lung Cancer
Targeted therapies and immune checkpoint inhibitors have transformed the treatment landscape for non–small cell lung cancer (NSCLC). Tyrosine kinase inhibitors (TKIs) have contributed to an overall decline in lung cancer–related mortality, and as they move into the early-stage setting, more dramatic improvements in outcomes are expected. However, combatting TKI resistance in NSCLC is largely an unmet challenge. Tissue next-generation sequencing and plasma circulating tumor DNA–based assays have emerged as concurrent methods to identify targetable mechanisms of resistance to TKIs at the time of clinical progression, while antibody-drug conjugates represent a promising therapeutic class for the treatment of TKI-resistant NSCLC.Source: ASCO Daily News
Spatial and Single Cell Characterization of Breast Cancer Progression: Presenter Profile
Presentation is about methods for assessment of multiple molecular variables on a single piece of tissue to better understand breast cancer (or really any cancer) with respect to progression or response or resistance to specific therapies.Source: SABCS Meeting News
Dhanpat Jain, MD, Joins Pathologists Nationwide in Calling for Continued Use of Remote Work in Clinical Laboratories and Pathology
A group of pathologists and laboratory leaders from across the U.S. is urging federal officials to continue certain regulatory exemptions implemented during the COVID-19 pandemic that allow the use of remote work in clinical laboratories and pathology.
ExPath Grad Student Madeline Mayday Awarded Grant from the NIDDK Cooperative Centers of Excellence in Hematology
Madeline Mayday, BS, a fourth-year Experimental Pathology graduate student in the Laboratory of Diane Krause, MD, PhD, was recently awarded a 2022 National Institute of Diabetes and Digestive and Kidney Diseases Hematology Centers Program Type B Pilot and Feasibility grant
American Joint Committee on Cancer Names Dhanpat Jain, MD, to Editorial Board
Dhanpat Jain, MD, Professor of Pathology and of Medicine (Digestive Diseases), has been named by the American Joint Committee on Cancer (AJCC) to its editorial board for neuroendocrine tumors of the gastrointestinal tract.
Yale Pathologists Say AI, Algorithms in Digital Pathology Will Have Lasting Impact on Education, Clinical Practice
The continued emergence and development of artificial intelligence and algorithms in digital pathology will greatly impact the practice and teaching of pathology, Angelique W. Levi, MD, Associate Professor of Pathology, and Sudhir Perincheri, MBBS, PhD, Assistant Professor of Pathology, said in a recent podcast.
Yale Cancer Center Researchers Awarded Grants by Breast Cancer Research Foundation
The Breast Cancer Research Foundation (BCRF) Scientific Advisory Board and its Board of Directors recently announced its 2022 research grants, including six funded grants at Yale Cancer Center and Smilow Cancer Hospital awarded to Mehra Golshan, MD, MBA, Melinda Irwin, PhD, MPH, Ian Krop, MD, PhD, Lajos Pusztai, MD, DPhil, David Rimm, MD, PhD, and Eric Winer, MD to support their research.
National Committee for Accreditation Program for Rectal Cancer Names Dhanpat Jain, MD, to its Quality Assurance Committee
The National Committee for Accreditation Program for Rectal Cancer (NAPRC) has named Dhanpat Jain, MD, Professor of Pathology and of Medicine (Digestive Diseases), to represent the College of American Pathologists on the NAPRC’s Quality Assurance Committee.
Rimm Lab Validates Objective Prognostic Marker in Patients With Early-stage Melanoma
An objective assessment of automated electronic tumor infiltrating lymphocytes percentage (eTILs%) scores is a strong prognostic marker in patients with early-stage melanoma. The study also identifies distinct TIL subpopulations that carry the prognostic values.
Dhanpat Jain, MD, Appointed to Cancer Committee of College of American Pathologists
Dhanpat Jain, MD, Professor of Pathology and of Medicine (Digestive Diseases), has been named to the Cancer Committee of the College of American Pathologists (CAP), the leading organization of board-certified pathologists that fosters and advocates excellence in the practice of pathology and laboratory medicine worldwide.
Yale Pathology to be Represented at the Pulmonary Pathology Society Meeting in Cork, Ireland
Sanja Dacic, MD, PhD, Vice Chair and Director of Anatomic Pathology at Yale Pathology and president of the Pulmonary Pathology Society (PPS), will be accompanied by the Yale Thoracic Pathology Service team at the PPS Biennial Meeting June 25-27 in Cork, Ireland.
Irina Krykbaeva, PhD, Awarded 2022 Milton C. Winternitz Prize in Pathology
Irina Krykbaeva, a recent PhD graduate in the Department of Pathology at Yale School of Medicine, is the winner of the 2022 Milton C. Winternitz Prize in Pathology. The prize is awarded annually to the student who, in the opinion of the department faculty and staff, has done outstanding work in the course.
Yale Pathology Diagnostic Pathology CME Annual Review Scheduled for September 17-18 at Yale Club of NYC
The Yale Department of Pathology presents its inaugural Diagnostic Pathology CME Annual Review on September 17-18 at the Yale Club of New York City. This inaugural course at the Yale Club in the heart of Midtown Manhattan will focus on the recent World Health Organization updates in all major pathology subspecialties.