Protection from Zika Virus May Lie in a Protein Derived from Mosquitoes
By targeting a protein found in the saliva of mosquitoes that transmit Zika virus, Yale investigators reduced Zika infection in mice. The finding demonstrates how researchers might develop a vaccine against Zika and similar mosquito-borne viruses, the study authors said.
Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex–Mediated Activation of the NLRP3 Inflammasome
Macrophage migration inhibitory factor (MIF), produced primarily from activated monocytes and macrophages, is an upstream activator of innate immune responses (1–3). In addition to its inhibition of monocyte migration and macrophage mobility, MIF promotes inflammatory responses by counter-regulating thinhibitory effect of glucocorticoids on the production of inflam- matory cytokines from macrophages, and by suppressing p53- dependent cell death (4,5). The MIF receptor complex is com- posed of the transmembrane ligand-binding component CD74 and the CD44 signaling component (6,7). MIF also competes with cognate ligands for CXCR4 and CXCR2, and directly binds to CXCR2 in a macromolecular receptor complex with CD74 (8).Source: Arthritis & Rheumatology
How do hair follicles grow? A Yale-led study untangles the science
An outstanding question in dermatology that researchers have studied for decades is: How do hair follicles emerge from a sea of seemingly uniform skin cells during embryonic development? New research findings from a Yale-led team offer answers to that question, which may lead to strategies for regenerating lost hair follicles in adults.
Yale Stem Cell Center will host two-day symposium to celebrate its 10th anniversary
Since it was founded in 2006, the Yale Stem Cell Center has supported the ground-breaking work of researchers and scientists working in basic stem cell research and translational science. On Thursday, Nov. 10, and Friday, Nov. 11, the center will hold a symposium in honor of its 10th anniversary.
DeLauro, Murphy push for more NIH funding directed at cancer ‘to accelerate’ progress toward cure
Collaboration, directing federal money to small, innovative companies and lightening restrictions on basic research were among the points made during a “cancer moonshot” roundtable held Tuesday at the Yale School of Nursing.Source: New Haven Register
Women’s Health Research at Yale funds pilot projects on debilitating and lethal diseases
Jumpstarting inventive research with major clinical implications, Women’s Health Research at Yale (WHRY) is supporting studies on vital women’s health issues via Pilot Project Program “seed” grants, as well as an inaugural Pioneer Award.
Expanded clean room facility available for cell therapy studies
The Department of Laboratory Medicine has recently expanded the Clinical GMP Laboratory, a state-of-the-art clean room facility that is housed within the department’s Transfusion Medicine Section. The department would like to hear from faculty who are planning to carry out clinical trials or other clinical studies involving cell therapy within the next five years.
Dr. Jordan Pober named the inaugural Bayer Professor of Translational Medicine
Dr. Jordan Pober, recently appointed as the inaugural Bayer Professor of Translational Medicine, conducts research aimed at understanding the functions of vascular endothelial cells in inflammatory and immune responses and, reciprocally, how inflammation and immunity affect vascular health and function.
Yale Psychiatry Names New Research Leaders at Connecticut Mental Health Center
Marina Picciotto, PhD, Deputy Chair for Basic Science and Charles B.G. Murphy Professor of Psychiatry, of Neuroscience, of Pharmacology and in the Child Study Center, has been named Director of the Ribicoff Labs and of the Division of Molecular Psychiatry. Christopher Pittenger, MD, PhD, Professor of Psychiatry, Assistant Chair for Translational Research, and Director of the Yale OCD Research Clinic, has been named Director of the Clinical Neuroscience Research Unit (CNRU) and of the Neuroscience Research Training Program (NRTP).
Potenza Named Director of Division on Addictions Research at Yale
Marc Potenza, MD, PhD (Yale College ’87, MD ’93, PhD ’94, Psychiatry Residency ‘98), Professor of Psychiatry, of Neuroscience, and in the Child Study Center, has been named Director of the Division on Addictions Research in the Yale Department of Psychiatry.
Fourth Annual Anesthesiology Department Celebration of Research Will Be Sept. 20-21
Renowned neuro-anesthesiologist and researcher George Mashour, MD PhD, the Bert N. Lau Professor of Anesthesiology Research and Associate Dean at University of Michigan Medical School, will be the keynote speaker.
Doris Duke Fund to Retain Clinical Scientists Now Accepting Applications
This program provides research funds to a select number of junior physician-scientists who are strongly committed to careers in clinical research, are engaged in funded research, and have a compelling need for the award in order to maintain research productivity in the face of extraordinary caregiving needs.