Peter Gershkovich, MD, MHA
Associate Professor of Pathology; Director, Section of Pathology Informatics and Cancer Data Science, Pathology
Research & Publications
Biography
News
Locations
Extensive Research Description
"Processing information faster and more efficiently, which today's technology can easily accomplish, is not sufficient. More intelligent processing, logical aggregation of information, synthesis, and analysis, and the development of knowledge systems that serve purposeful ends are needed." This is a quote from 1992 charter of NLM fellowship in applied informatics when it was just established remains even more relevant and critical today.
I have strong interest in rapid development methodologies and working on software that deals with systems integration and interoperability, supports Tumor DNA sequencing reporting, enables laboratory integration of digital pathology, and assists with analytics, information retrieval, and visualization.
Coauthors
Selected Publications
- NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological healthLee P, Benz C, Blood P, Börner K, Campisi J, Chen F, Daldrup-Link H, De Jager P, Ding L, Duncan F, Eickelberg O, Fan R, Finkel T, Furman D, Garovic V, Gehlenborg N, Glass C, Heckenbach I, Joseph Z, Katiyar P, Kim S, Königshoff M, Kuchel G, Lee H, Lee J, Ma J, Ma Q, Melov S, Metis K, Mora A, Musi N, Neretti N, Passos J, Rahman I, Rivera-Mulia J, Robson P, Rojas M, Roy A, Scheibye-Knudsen M, Schilling B, Shi P, Silverstein J, Suryadevara V, Xie J, Wang J, Wong A, Niedernhofer L, Wang S, Anvari H, Balough J, Benz C, Bons J, Brenerman B, Evans W, Gerencser A, Gregory H, Hansen M, Justice J, Kapahi P, Murad N, O’Broin A, Pavone M, Powell M, Scott G, Shanes E, Shankaran M, Verdin E, Winer D, Wu F, Adams A, Blood P, Bueckle A, Cao-Berg I, Chen H, Davis M, Filus S, Hao Y, Hartman A, Hasanaj E, Helfer J, Herr B, Joseph Z, Molla G, Mou G, Puerto J, Quardokus E, Ropelewski A, Ruffalo M, Satija R, Schwenk M, Scibek R, Shirey W, Sibilla M, Welling J, Yuan Z, Bonneau R, Christiano A, Izar B, Menon V, Owens D, Phatnani H, Smith C, Suh Y, Teich A, Bekker V, Chan C, Coutavas E, Hartwig M, Ji Z, Nixon A, Dou Z, Rajagopal J, Slavov N, Holmes D, Jurk D, Kirkland J, Lagnado A, Tchkonia T, Abraham K, Dibattista A, Fridell Y, Howcroft T, Jhappan C, Montes V, Prabhudas M, Resat H, Taylor V, Kumar M, Suryadevara V, Cigarroa F, Cohn R, Cortes T, Courtois E, Chuang J, Davé M, Domanskyi S, Enninga E, Eryilmaz G, Espinoza S, Gelfond J, Kirkland J, Kuchel G, Kuo C, Lehman J, Aguayo-Mazzucato C, Meves A, Rani M, Sanders S, Thibodeau A, Tullius S, Ucar D, White B, Wu Q, Xu M, Yamaguchi S, Assarzadegan N, Cho C, Hwang I, Hwang Y, Xi J, Adeyi O, Aliferis C, Bartolomucci A, Dong X, DuFresne-To M, Ikramuddin S, Johnson S, Nelson A, Niedernhofer L, Revelo X, Trevilla-Garcia C, Sedivy J, Thompson E, Robbins P, Wang J, Aird K, Alder J, Beaulieu D, Bueno M, Calyeca J, Chamucero-Millaris J, Chan S, Chung D, Corbett A, Gorbunova V, Gowdy K, Gurkar A, Horowitz J, Hu Q, Kaur G, Khaliullin T, Lafyatis R, Lanna S, Li D, Ma A, Morris A, Muthumalage T, Peters V, Pryhuber G, Reader B, Rosas L, Sembrat J, Shaikh S, Shi H, Stacey S, Croix C, Wang C, Wang Q, Watts A, Gu L, Lin Y, Rabinovitch P, Sweetwyne M, Artyomov M, Ballentine S, Chheda M, Davies S, DiPersio J, Fields R, Fitzpatrick J, Fulton R, Imai S, Jain S, Ju T, Kushnir V, Link D, Ben Major M, Oh S, Rapp D, Rettig M, Stewart S, Veis D, Vij K, Wendl M, Wyczalkowski M, Craft J, Enninful A, Farzad N, Gershkovich P, Halene S, Kluger Y, VanOudenhove J, Xu M, Yang J, Yang M. NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health. Nature Aging 2022, 2: 1090-1100. PMID: 36936385, PMCID: PMC10019484, DOI: 10.1038/s43587-022-00326-5.
- Systems approach to enhance Lynch syndrome diagnosis through tumour testingSingh V, Mezzacappa C, Gershkovich P, Di Giovanna J, Ganzak A, Gibson J, Sinard J, Xicola RM, Llor X. Systems approach to enhance Lynch syndrome diagnosis through tumour testing. Journal Of Medical Genetics 2022, 60: 533-539. PMID: 36115663, PMCID: PMC10020126, DOI: 10.1136/jmg-2022-108770.
- QIM22-192: Mismatch Repair Protein Immunohistochemistry: Quality of Mismatch Repair Deficiency DetectionMatsumoto N, Barbieri A, Gershkovich P, Cecchini M, Gibson J. QIM22-192: Mismatch Repair Protein Immunohistochemistry: Quality of Mismatch Repair Deficiency Detection. Journal Of The National Comprehensive Cancer Network 2022, 20: qim22-192. DOI: 10.6004/jnccn.2021.7192.
- Abstract PO-052: A multisystem approach doubles the number of patients referred for genetic testing and diagnosed with Lynch syndrome with equally success among ethnic/racial groupsSingh V, Ganzak A, Gershkovich P, Gibson J, Xicola R, Llor X. Abstract PO-052: A multisystem approach doubles the number of patients referred for genetic testing and diagnosed with Lynch syndrome with equally success among ethnic/racial groups. Cancer Epidemiology Biomarkers & Prevention 2022, 31: po-052-po-052. DOI: 10.1158/1538-7755.disp21-po-052.
- Su076 COST-EFFECTIVENESS ANALYSIS OF SCREENING STRATEGIES FOR LYNCH SYNDROME UNDER DIFFERENT SYSTEMS APPROACHESZhu J, Singh V, Gershkovich P, Ganzak A, Gibson J, Yaesoubi R, Llor X. Su076 COST-EFFECTIVENESS ANALYSIS OF SCREENING STRATEGIES FOR LYNCH SYNDROME UNDER DIFFERENT SYSTEMS APPROACHES. Gastroenterology 2021, 160: s-606-s-607. DOI: 10.1016/s0016-5085(21)02152-1.
- An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracyPerincheri S, Levi AW, Celli R, Gershkovich P, Rimm D, Morrow JS, Rothrock B, Raciti P, Klimstra D, Sinard J. An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy. Modern Pathology 2021, 34: 1588-1595. PMID: 33782551, PMCID: PMC8295034, DOI: 10.1038/s41379-021-00794-x.
- Measuring Faculty Effort: A Quantitative Approach That Aligns Personal and Institutional Goals in Pathology at YaleMorrow JS, Gershkovich P, Gibson J, Gilshannon M, Kowalski D, Levi AW, Nguyen DX, Rimm DL, Xu ML, Sinard J. Measuring Faculty Effort: A Quantitative Approach That Aligns Personal and Institutional Goals in Pathology at Yale. Academic Pathology 2021, 8: 23742895211047985. PMID: 34646939, PMCID: PMC8504692, DOI: 10.1177/23742895211047985.
- 1 IMPROVING LYNCH SYNDROME IDENTIFICATION THROUGH THE IMPLEMENTATION OF ENHANCED TUMOR TESTING AND A COMPREHENSIVE SYSTEMS APPROACHSingh V, Ganzak A, Gershkovich P, Gibson J, Llor X. 1 IMPROVING LYNCH SYNDROME IDENTIFICATION THROUGH THE IMPLEMENTATION OF ENHANCED TUMOR TESTING AND A COMPREHENSIVE SYSTEMS APPROACH. Gastroenterology 2020, 158: s-1. DOI: 10.1016/s0016-5085(20)30682-x.
- TQuest, A Web-Based Platform to Enable Precision Medicine by Linking a Tumor’s Genetic Defects to Therapeutic OptionsGershkovich P, Platt J, Knopf J, Tasoulis MK, Shi W, Pusztai L, Hatzis C. TQuest, A Web-Based Platform to Enable Precision Medicine by Linking a Tumor’s Genetic Defects to Therapeutic Options. JCO Clinical Cancer Informatics 2018, 2: 1-13. PMID: 30652574, DOI: 10.1200/cci.17.00120.
- Customizing Laboratory Information SystemsGershkovich P, Sinard JH. Customizing Laboratory Information Systems. Advances In Anatomic Pathology 2015, 22: 323-330. PMID: 26262515, DOI: 10.1097/pap.0000000000000088.
- Mutation-based treatment recommendations from next generation sequencing data: A comparison of web tools.Patel J, Reiner E, Bossuyt V, Epstein L, Platt J, DiGiovanna M, Chung G, Silber A, Sanft T, Hofstatter E, Mougalian S, Abu-Khalaf M, Gershkovich P, Hatzis C, Pusztai L. Mutation-based treatment recommendations from next generation sequencing data: A comparison of web tools. Journal Of Clinical Oncology 2015, 33: e12564-e12564. DOI: 10.1200/jco.2015.33.15_suppl.e12564.
- Are Amended Surgical Pathology Reports Getting to the Correct Responsible Care Provider?Parkash V, Domfeh A, Cohen P, Fischbach N, Pronovost M, Haines GK, Gershkovich P. Are Amended Surgical Pathology Reports Getting to the Correct Responsible Care Provider? American Journal Of Clinical Pathology 2014, 142: 58-63. PMID: 24926086, DOI: 10.1309/ajcpy55evinjclgx.
- A Retrospective Population-Based Comparison of HER2 Immunohistochemistry and Fluorescence In Situ Hybridization in Breast Carcinomas: Impact of 2007 American Society of Clinical Oncology/ College of American Pathologists CriteriaSchalper KA, Kumar S, Hui P, Rimm DL, Gershkovich P. A Retrospective Population-Based Comparison of HER2 Immunohistochemistry and Fluorescence In Situ Hybridization in Breast Carcinomas: Impact of 2007 American Society of Clinical Oncology/ College of American Pathologists Criteria. Archives Of Pathology & Laboratory Medicine 2013, 138: 213-9. PMID: 24164555, DOI: 10.5858/arpa.2012-0617-oa.
- Custom software development for use in a clinical laboratorySinard JH, Gershkovich P. Custom software development for use in a clinical laboratory. Journal Of Pathology Informatics 2012, 3: 44. PMID: 23372985, PMCID: PMC3551490, DOI: 10.4103/2153-3539.104906.
- Standardization of Estrogen Receptor Measurement in Breast Cancer Suggests False-Negative Results Are a Function of Threshold Intensity Rather Than Percentage of Positive CellsWelsh AW, Moeder CB, Kumar S, Gershkovich P, Alarid ET, Harigopal M, Haffty BG, Rimm DL. Standardization of Estrogen Receptor Measurement in Breast Cancer Suggests False-Negative Results Are a Function of Threshold Intensity Rather Than Percentage of Positive Cells. Journal Of Clinical Oncology 2011, 29: 2978-2984. PMID: 21709197, PMCID: PMC3157961, DOI: 10.1200/jco.2010.32.9706.
- Dynamic Display of Turnaround Time Via Interactive 2D ImagesGershkovich P, Tselovalnikov A. Dynamic Display of Turnaround Time Via Interactive 2D Images. 2007, 4370: 55-62. DOI: 10.1007/978-3-540-71027-1_6.
- An approach to object-relational mapping in bioscience domains.Tuck D, O'Connell R, Gershkovich P, Cowan J. An approach to object-relational mapping in bioscience domains. Proceedings / AMIA ... Annual Symposium. AMIA Symposium 2002, 820-4. PMID: 12463939, PMCID: PMC2244333.
- An implementation framework for GEM encoded guidelines.Gershkovich P, Shiffman RN. An implementation framework for GEM encoded guidelines. AMIA Annual Symposium Proceedings 2001, 204-8. PMID: 11825181, PMCID: PMC2243348.
- An approach to guideline implementation with GEM.Shiffman RN, Agrawal A, Deshpande AM, Gershkovich P. An approach to guideline implementation with GEM. 2001, 84: 271-5. PMID: 11604747.