Haris Mirza, MD, PhD
Instructor
Research & Publications
Biography
News
Coauthors
Selected Publications
- 1025 Tumor-specific CD8+ T cells epigenetically licensed by IL-7R are critical for anti-tumor immunity in melanomaMicevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn H, Sefik E, Cheung J, Hornick N, Aizenbud L, Joshi N, Kluger H, Iwasaki A, Bosenberg M, Flavell R. 1025 Tumor-specific CD8+ T cells epigenetically licensed by IL-7R are critical for anti-tumor immunity in melanoma. 2023, a1133-a1133. DOI: 10.1136/jitc-2023-sitc2023.1025.
- Humanized mouse liver reveals endothelial control of essential hepatic metabolic functionsKaffe E, Roulis M, Zhao J, Qu R, Sefik E, Mirza H, Zhou J, Zheng Y, Charkoftaki G, Vasiliou V, Vatner D, Mehal W, AlcHepNet, Kluger Y, Flavell R. Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions. Cell 2023, 186: 3793-3809.e26. PMID: 37562401, PMCID: PMC10544749, DOI: 10.1016/j.cell.2023.07.017.
- IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memoryMicevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn H, Sefik E, Cheung J, Hornick N, Aizenbud L, Joshi N, Kluger H, Iwasaki A, Bosenberg M, Flavell R. IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2304319120. PMID: 37459511, PMCID: PMC10372654, DOI: 10.1073/pnas.2304319120.
- Editorial: Methods and applications in inflammation pharmacologySchmidtchen A, Mirza H, van der Plas M, Nadeem A, Puthia M. Editorial: Methods and applications in inflammation pharmacology. Frontiers In Pharmacology 2022, 13: 1108263. PMID: 36578538, PMCID: PMC9792174, DOI: 10.3389/fphar.2022.1108263.
- An update on ductal plate malformations and fibropolycystic diseases of the liverMirza H, Besse W, Somlo S, Weinreb J, Kenney B, Jain D. An update on ductal plate malformations and fibropolycystic diseases of the liver. Human Pathology 2022, 132: 102-113. PMID: 35777701, DOI: 10.1016/j.humpath.2022.06.022.
- Inflammasome activation in infected macrophages drives COVID-19 pathologySefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Inflammasome activation in infected macrophages drives COVID-19 pathology. Nature 2022, 606: 585-593. PMID: 35483404, PMCID: PMC9288243, DOI: 10.1038/s41586-022-04802-1.
- A humanized mouse model of chronic COVID-19Sefik E, Israelow B, Mirza H, Zhao J, Qu R, Kaffe E, Song E, Halene S, Meffre E, Kluger Y, Nussenzweig M, Wilen CB, Iwasaki A, Flavell RA. A humanized mouse model of chronic COVID-19. Nature Biotechnology 2021, 40: 906-920. PMID: 34921308, PMCID: PMC9203605, DOI: 10.1038/s41587-021-01155-4.
- 832 Mechanisms of spontaneous genetic reversion in ichthyosis with confettiLim Y, Lu Y, Mirza H, Zhou J, Hu R, Choate K. 832 Mechanisms of spontaneous genetic reversion in ichthyosis with confetti. Journal Of Investigative Dermatology 2018, 138: s141. DOI: 10.1016/j.jid.2018.03.842.
- 351 Epidermal fragility in Keratin 10 ichthyosis with confetti mutation results from loss of keratin 1-desmoplakin interactionLu Y, Mirza H, Hu R, Zhou J, Crumrine D, Elias P, Lifton R, Choate K. 351 Epidermal fragility in Keratin 10 ichthyosis with confetti mutation results from loss of keratin 1-desmoplakin interaction. Journal Of Investigative Dermatology 2016, 136: s62. DOI: 10.1016/j.jid.2016.02.383.
- 373 Keratin network is regulated by nonsense mediated decay and ubiquitin-proteosome in epidermolyic ichthyosisMirza H, Lian R, Hu R, Zhou J, Choate K. 373 Keratin network is regulated by nonsense mediated decay and ubiquitin-proteosome in epidermolyic ichthyosis. Journal Of Investigative Dermatology 2016, 136: s66. DOI: 10.1016/j.jid.2016.02.406.
- Mutations Affecting Keratin 10 Surface-Exposed Residues Highlight the Structural Basis of Phenotypic Variation in Epidermolytic IchthyosisMirza H, Kumar A, Craiglow BG, Zhou J, Saraceni C, Torbeck R, Ragsdale B, Rehder P, Ranki A, Choate KA. Mutations Affecting Keratin 10 Surface-Exposed Residues Highlight the Structural Basis of Phenotypic Variation in Epidermolytic Ichthyosis. Journal Of Investigative Dermatology 2015, 135: 3041-3050. PMID: 26176760, DOI: 10.1038/jid.2015.284.
- Bimodal Influence of Vitamin D in Host Response to Systemic Candida Infection—Vitamin D Dose MattersLim JH, Ravikumar S, Wang YM, Thamboo TP, Ong L, Chen J, Goh JG, Tay SH, Chengchen L, Win MS, Leong W, Lau T, Foo R, Mirza H, Tan KS, Sethi S, Khoo AL, Chng WJ, Osato M, Netea MG, Wang Y, Chai LY. Bimodal Influence of Vitamin D in Host Response to Systemic Candida Infection—Vitamin D Dose Matters. The Journal Of Infectious Diseases 2015, 212: 635-644. PMID: 25612733, DOI: 10.1093/infdis/jiv033.
- Intra-Subtype Variation in Enteroadhesion Accounts for Differences in Epithelial Barrier Disruption and Is Associated with Metronidazole Resistance in Blastocystis Subtype-7Wu Z, Mirza H, Tan KS. Intra-Subtype Variation in Enteroadhesion Accounts for Differences in Epithelial Barrier Disruption and Is Associated with Metronidazole Resistance in Blastocystis Subtype-7. PLOS Neglected Tropical Diseases 2014, 8: e2885. PMID: 24851944, PMCID: PMC4031124, DOI: 10.1371/journal.pntd.0002885.
- Strain-Dependent Induction of Human Enterocyte Apoptosis by Blastocystis Disrupts Epithelial Barrier and ZO-1 Organization in a Caspase 3- and 9-Dependent MannerWu Z, Mirza H, Teo JD, Tan KS. Strain-Dependent Induction of Human Enterocyte Apoptosis by Blastocystis Disrupts Epithelial Barrier and ZO-1 Organization in a Caspase 3- and 9-Dependent Manner. BioMed Research International 2014, 2014: 209163. PMID: 24822183, PMCID: PMC4009109, DOI: 10.1155/2014/209163.
- Clinical Aspects of Blastocystis Infections: Advancements Amidst ControversiesMirza H, Tan K. Clinical Aspects of Blastocystis Infections: Advancements Amidst Controversies. 2012, 4: 65-84. DOI: 10.1007/978-3-642-32738-4_5.
- ConclusionsMehlhorn H, Yamada M, Yoshikawa H, Tan K, Mirza H, Boorom K. Conclusions. 2012, 4: 215-217. DOI: 10.1007/978-3-642-32738-4_11.
- Landmarks in the Discovery of Blastocystis StagesMehlhorn H, Yamada M, Yoshikawa H, Tan K, Mirza H, Boorom K. Landmarks in the Discovery of Blastocystis Stages. 2012, 4: 1-8. DOI: 10.1007/978-3-642-32738-4_1.
- Blastocystis–Host Interactions: Insights from In Vitro Model SystemsTan K, Mirza H. Blastocystis–Host Interactions: Insights from In Vitro Model Systems. 2012, 4: 51-63. DOI: 10.1007/978-3-642-32738-4_4.
- Statin pleiotropy prevents rho kinase‐mediated intestinal epithelial barrier compromise induced by Blastocystis cysteine proteasesMirza H, Wu Z, Teo JD, Tan KS. Statin pleiotropy prevents rho kinase‐mediated intestinal epithelial barrier compromise induced by Blastocystis cysteine proteases. Cellular Microbiology 2012, 14: 1474-1484. PMID: 22587300, DOI: 10.1111/j.1462-5822.2012.01814.x.
- A Metronidazole-Resistant Isolate of Blastocystis spp. Is Susceptible to Nitric Oxide and Downregulates Intestinal Epithelial Inducible Nitric Oxide Synthase by a Novel Parasite Survival MechanismMirza H, Wu Z, Kidwai F, Tan KS. A Metronidazole-Resistant Isolate of Blastocystis spp. Is Susceptible to Nitric Oxide and Downregulates Intestinal Epithelial Inducible Nitric Oxide Synthase by a Novel Parasite Survival Mechanism. Infection And Immunity 2011, 79: 5019-5026. PMID: 21930763, PMCID: PMC3232666, DOI: 10.1128/iai.05632-11.
- Epidemiology of rheumatoid arthritis in a tertiary care unit, Karachi, Pakistan.Alam SM, Kidwai AA, Jafri SR, Qureshi BM, Sami A, Qureshi HH, Mirza H. Epidemiology of rheumatoid arthritis in a tertiary care unit, Karachi, Pakistan. Journal Of The Pakistan Medical Association 2011, 61: 123-6. PMID: 21375157.
- A Rapid, High-Throughput Viability Assay for Blastocystis spp. Reveals Metronidazole Resistance and Extensive Subtype-Dependent Variations in Drug SusceptibilitiesMirza H, Teo JD, Upcroft J, Tan KS. A Rapid, High-Throughput Viability Assay for Blastocystis spp. Reveals Metronidazole Resistance and Extensive Subtype-Dependent Variations in Drug Susceptibilities. Antimicrobial Agents And Chemotherapy 2010, 55: 637-648. PMID: 21098237, PMCID: PMC3028762, DOI: 10.1128/aac.00900-10.
- Current Views on the Clinical Relevance of Blastocystis spp.Tan KS, Mirza H, Teo JD, Wu B, MacAry PA. Current Views on the Clinical Relevance of Blastocystis spp. Current Infectious Disease Reports 2010, 12: 28-35. PMID: 21308496, DOI: 10.1007/s11908-009-0073-8.
- CS8-02 Blastocystis-Host Interactions: New Insights on PathogenesisTan K, Mirza H. CS8-02 Blastocystis-Host Interactions: New Insights on Pathogenesis. International Journal Of Infectious Diseases 2009, 13: s11. DOI: 10.1016/s1201-9712(09)60274-5.
- Blastocystis exhibits inter- and intra-subtype variation in cysteine protease activityMirza H, Tan KS. Blastocystis exhibits inter- and intra-subtype variation in cysteine protease activity. Parasitology Research 2008, 104: 355-361. PMID: 18846388, DOI: 10.1007/s00436-008-1203-1.