Alfred Bothwell, PhD
Professor Emeritus of ImmunobiologyCards
About
Titles
Professor Emeritus of Immunobiology
Member of HTI and VBT
Biography
Al Bothwell graduated with an A.B. from Washington University in 1971, got a PhD from Yale in Sidney Altman’s lab in 1975 and then did a postdoc with David Baltimore at MIT where he established the genetic basis of the anti-NP idiotypic antibody response. He has been on the Immunobiology faculty at the Yale Medical School since 1982. He continued studies of B cell antibody diversity and memory and then worked on T cell receptor structure/function and signaling. He also developed the molecular genetics of the Ly6 gene family (aka Sca-1/Ly6A and Ly6C). Increasingly his work has shifted to studies of human immunity with development of humanized mouse models of vascular disease/transplantation, type 1 diabetes and cancer. Studies on gut inflammation in a genetic tumor model and Inflammatory Bowel Disease have lead most recently to contributions concerning wnt signaling to infections and asthma. His studies focus on the remarkable immunoregulatory properties of Wnt signaling that is both canonical and non-canonical and involves direct interaction with platelets.This is a basic mechanism for regulating tissue permeability affecting the mobility of lymphocytes and tumor cells.
Appointments
Immunobiology
EmeritusPrimaryImmunobiology
Senior Research ScientistSecondary
Other Departments & Organizations
- Diabetes Research Center
- Fellowship Training
- Human and Translational Immunology Program
- Immunobiology
- Program for Biomedical Ethics
- Rheumatic Diseases Research Core
- Vascular Biology and Therapeutics Program
- WHRY Pilot Project Program Investigators
- Women's Health Research at Yale
- Yale Cancer Center
- Yale Center for Immuno-Oncology
- Yale Ventures
Education & Training
- Postdoctoral Fellow
- MIT (1982)
- Postdoctoral Fellow
- Cold Spring Harbor Laboratory (1976)
- PhD
- Yale University, Biology (1975)
- BA
- Washington University, Biology Dept. (1971)
Research
Links & Media
News
- February 11, 2018
Researchers develop novel immunotherapy to target colorectal cancer
- September 26, 2016
Yale Researchers Tackle Ovarian Cancer and Heart Attacks in WHRY-Funded Studies
- June 09, 2016
How a Mouse Can Build a Better Cancer Trap
- February 08, 2016
Research in the news: Yale study identifies new target for severe asthma, chronic inflammatory diseases