Yu Jin, MD, PhD
Associate Research Scientist in PathologyCards
About
Research
Publications
2026
Smooth Muscle Cell-Specific Expression of Cyclic Nucleotide Phosphodiesterase 10a Promotes the Development of Medial Artery Calcification.
Jin Y, Xie Y, Davis S, Flores A, Wang X, Guzman R, Cai Y. Smooth Muscle Cell-Specific Expression of Cyclic Nucleotide Phosphodiesterase 10a Promotes the Development of Medial Artery Calcification. Journal Of The American Society Of Nephrology 2026 PMID: 42308131, DOI: 10.1681/asn.0000001164.Peer-Reviewed Original ResearchVascular smooth muscle cells in vitroSmooth muscle cells in vitroMuscle cells in vitroMedial arterial calcificationArtery calcificationCells in vitroTAK-063Calcification in vivoAssociated with high cardiovascular morbiditySmooth muscle cell calcificationPeripheral arterial disease patientsCyclic nucleotide phosphodiesterase 10AHigh cardiovascular morbidityTibial arteryInhibition of PDE10AArtery disease patientsPeripheral arterial diseaseVitamin D3 injectionIn vivo modelsAortic ring modelCyclic nucleotides cAMPArteries in vivoNephrectomy modelCardiovascular morbidityGlobal deletion
2025
Authors' Reply: Clarifying On-Target p38 Inhibition and Protein Restriction Effects in CKD-Associated Vascular Calcification
Jin Y, Guzman R, Cai Y. Authors' Reply: Clarifying On-Target p38 Inhibition and Protein Restriction Effects in CKD-Associated Vascular Calcification. Journal Of The American Society Of Nephrology 2025, 37: 896-896. PMID: 41563795, PMCID: PMC13065118, DOI: 10.1681/asn.0000000972.Commentaries, Editorials and LettersAuthors' Reply: A Calciprotein Particle–Centric Framework for Vascular Calcification in CKD Models
Jin Y, Guzman R, Cai Y. Authors' Reply: A Calciprotein Particle–Centric Framework for Vascular Calcification in CKD Models. Journal Of The American Society Of Nephrology 2025, 37: 899-899. PMID: 41563831, PMCID: PMC13065117, DOI: 10.1681/asn.0000000937.Commentaries, Editorials and LettersHigh Phosphate and Low Protein Mediate Arterial and Cutaneous Vascular Calcification in CKD Mice
Jin Y, Cao F, Xie Y, Davis S, Dong G, Nigwekar S, Hansen J, Guzman R, Cai Y. High Phosphate and Low Protein Mediate Arterial and Cutaneous Vascular Calcification in CKD Mice. Journal Of The American Society Of Nephrology 2025, 37: 683-699. PMID: 40960881, PMCID: PMC12448113, DOI: 10.1681/asn.0000000875.Peer-Reviewed Original ResearchChronic kidney diseaseChronic kidney disease miceCutaneous vascular calcificationArteriolar calcificationVascular calcificationP38 MAPK signalingMedial arterial calcificationPharmacological inhibition of p38 MAPK signalingArtery calcificationLow-protein dietPharmacological inhibitionMedial arteryInhibition of p38 MAPK signalingCKD mouse modelMolecular pathwaysMAPK signalingExperimental CKD modelsPharmacological inhibitor SB203580Kidney impairmentAlizarin red stainingNephrectomy miceSignaling in vivoVascular complicationsKidney dysfunctionTreatment strategies
2024
Cathepsin B Nuclear Flux in a DNA-Guided “Antinuclear Missile” Cancer Therapy
Cao F, Tang C, Chen X, Tu Z, Jin Y, Turk O, Nishimura R, Ebens A, Dubljevic V, Campbell J, Zhou J, Hansen J. Cathepsin B Nuclear Flux in a DNA-Guided “Antinuclear Missile” Cancer Therapy. ACS Central Science 2024, 10: 1562-1572. PMID: 39220699, PMCID: PMC11363321, DOI: 10.1021/acscentsci.4c00559.Peer-Reviewed Original ResearchAntinuclear antibodiesCancer therapyTumor-specific surface antigenLysosomal protease cathepsin BAntibody-drug conjugatesNecrotic tumorTumor environmentExtracellular nucleic acidsSurface antigensProtease cathepsin BCancer cellsTumorNucleoside salvage pathwayDrug linkersNucleoside salvageTherapyCross membrane barriersMembrane barrierCathepsin BLiving cancer cellsDNA guidesAntinuclearSalvage pathwayCathepsinNuclear penetrationSmooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification
Xie Y, Lin T, Jin Y, Berezowitz A, Wang X, Lu J, Cai Y, Guzman R. Smooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification. Cardiovascular Research 2024, 120: 658-670. PMID: 38454645, PMCID: PMC11074797, DOI: 10.1093/cvr/cvae035.Peer-Reviewed Original ResearchSmooth muscle cellsPeripheral arterial diseaseVascular smooth muscle cellsMedial calcificationMMP-3Osteogenic transformationRodent modelsAssociated with increased morbiditySmooth muscle cell calcificationChronic kidney diseaseEx vivo organ culture modelMMP-3 expressionOrgan culture modelMedial arterial calcificationTargeting MMP-3Matrix metalloproteinase 3MMP-3 proteinArtery calcificationArtery diseaseKidney diseaseVascular calcificationMuscle cellsTherapeutic strategiesCalcification mediumVitamin D3
2023
Multi-omic analysis reveals metabolic pathways that characterize right-sided colon cancer liver metastasis
Morris M, Jain A, Sun B, Kurbatov V, Muca E, Zeng Z, Jin Y, Roper J, Lu J, Paty P, Johnson C, Khan S. Multi-omic analysis reveals metabolic pathways that characterize right-sided colon cancer liver metastasis. Cancer Letters 2023, 574: 216384. PMID: 37716465, PMCID: PMC10620771, DOI: 10.1016/j.canlet.2023.216384.Peer-Reviewed Original ResearchConceptsLiver metastasesColon cancer liver metastasisCancer liver metastasesSided colon cancerSubset of patientsGrowth factor betaMulti-omics analysisFatty acid oxidationMetastatic diseaseInferior survivalClinical differencesClinical behaviorUntargeted metabolomics analysisTumor behaviorColon cancerBile acidsTumor cell metabolismFactor betaPatientsMetastasisPI3K-AktReactive oxygen speciesMEK-ERKLiquid chromatography-mass spectrometryRCC
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