Raul J Guzman, MD
Donald Guthrie Professor of Vascular Surgery, Vice Chair, Faculty AffairsCards
About
Research
Publications
2026
Outcomes of Infrainguinal Bypass With Spliced Veins in Patients With Chronic Limb-threatening Ischemia
Creisher B, Bao L, Carter W, Aboian E, Strosberg D, Arhuidese I, Tonnessen B, Cardella J, Guzman R, Chaar C. Outcomes of Infrainguinal Bypass With Spliced Veins in Patients With Chronic Limb-threatening Ischemia. Journal Of Vascular Surgery 2026, 84: e7-e8. DOI: 10.1016/j.jvs.2026.03.452.Peer-Reviewed Original ResearchA Personalized Prediction Model for Postcontrast Acute Kidney Injury After Peripheral Vascular Intervention
Phu T, Wang C, Bader J, Huang Y, Slade M, Aboian E, Zwibelman H, Cardella J, Guzman R, Chaar C. A Personalized Prediction Model for Postcontrast Acute Kidney Injury After Peripheral Vascular Intervention. Journal Of Vascular Surgery 2026, 84: e161-e162. DOI: 10.1016/j.jvs.2026.03.244.Peer-Reviewed Original ResearchPCSK9 Inhibitors Are Associated With Improved Amputation-free Survival After Lower Extremity Revascularization
Wells N, Cross J, Badusi P, Carter W, Possick S, Tonnessen B, Cardella J, Guzman R, Desai N, Chaar C. PCSK9 Inhibitors Are Associated With Improved Amputation-free Survival After Lower Extremity Revascularization. Journal Of Vascular Surgery 2026, 84: e71-e72. DOI: 10.1016/j.jvs.2026.03.552.Peer-Reviewed Original ResearchRisks and Benefits of Triple Therapy Compared to Dual Antiplatelet Therapy After Lower Extremity Revascularization
Wells N, Carter W, Ramalingam R, Dhanda U, Tran L, Silva D, Tonnessen B, Cardella J, Guzman R, Chaar C. Risks and Benefits of Triple Therapy Compared to Dual Antiplatelet Therapy After Lower Extremity Revascularization. Journal Of Vascular Surgery 2026, 84: e72-e75. DOI: 10.1016/j.jvs.2026.03.553.Peer-Reviewed Original ResearchAnemia Increases 30-day Mortality and Major Amputation After Endovascular Peripheral Vascular Interventions
Ho B, Arhuidese I, Tonnessen B, Cardella J, Guzman R, Dardik A, Chaar C. Anemia Increases 30-day Mortality and Major Amputation After Endovascular Peripheral Vascular Interventions. Journal Of Vascular Surgery 2026, 84: e235-e236. DOI: 10.1016/j.jvs.2026.03.339.Peer-Reviewed Original ResearchSmooth Muscle Cell-Specific Expression of Cyclic Nucleotide Phosphodiesterase 10a Promotes the Development of Medial Artery Calcification.
Jin Y, Xie Y, Davis S, Flores A, Wang X, Guzman R, Cai Y. Smooth Muscle Cell-Specific Expression of Cyclic Nucleotide Phosphodiesterase 10a Promotes the Development of Medial Artery Calcification. Journal Of The American Society Of Nephrology 2026 PMID: 42308131, DOI: 10.1681/asn.0000001164.Peer-Reviewed Original ResearchVascular smooth muscle cells in vitroSmooth muscle cells in vitroMuscle cells in vitroMedial arterial calcificationArtery calcificationCells in vitroTAK-063Calcification in vivoAssociated with high cardiovascular morbiditySmooth muscle cell calcificationPeripheral arterial disease patientsCyclic nucleotide phosphodiesterase 10AHigh cardiovascular morbidityTibial arteryInhibition of PDE10AArtery disease patientsPeripheral arterial diseaseVitamin D3 injectionIn vivo modelsAortic ring modelCyclic nucleotides cAMPArteries in vivoNephrectomy modelCardiovascular morbidityGlobal deletionHydration attenuates incidental iliac vein stenosis detected by magnetic resonance imaging in deliberately fasted asymptomatic individuals
Schultz K, Gathagan R, Kuehne A, Rodriguez P, Huber S, Attaran R, Perez Lozada J, Tonnessen B, Aboian E, Guzman R, Chaar C. Hydration attenuates incidental iliac vein stenosis detected by magnetic resonance imaging in deliberately fasted asymptomatic individuals. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2026, 14: 102531. PMID: 42203150, DOI: 10.1016/j.jvsv.2026.102531.Peer-Reviewed Original ResearchCommon iliac veinIliac vein stenosisExternal iliac veinLeft common iliac veinMagnetic resonance imagingProportion of participantsIliac veinIntravascular hydrationVein stenosisVenous symptomsMedian body mass indexAsymptomatic individualsBilateral common iliac veinsRight external iliac veinLeft external iliac veinResonance imagingBody mass indexNormal saline administrationNarrowest cross-sectional areaTertiary academic hospitalCross-sectional areaSymptomatic patientsIndependent reviewersSaline administrationAnatomical variantsSodium Glucose Cotransporter-2 Inhibitors are Not Associated with Amputation After Lower Extremity Revascularization in Patients with Diabetes
Alappan U, Chetty A, Carter W, Wells N, Alameddine D, Inzucchi S, Guzman R, Ochoa Chaar C. Sodium Glucose Cotransporter-2 Inhibitors are Not Associated with Amputation After Lower Extremity Revascularization in Patients with Diabetes. Annals Of Vascular Surgery 2026, 130: 415-424. PMID: 42162856, DOI: 10.1016/j.avsg.2026.04.067.Peer-Reviewed Original ResearchSodium-glucose cotransporter-2 inhibitorsLower extremity revascularizationPeripheral arterial diseaseCotransporter-2 inhibitorsRetrospective cohort reviewDiabetes mellitusSGLT2i useKaplan-MeierExtremity revascularizationKM analysisReturn to operating roomShorter length of hospital stayLength of hospital stayPostoperative hemoglobin A1cReview of patientsTertiary care centerEndovascular lower extremity revascularizationLong-term outcomesChronic limb-threatening ischemiaAll-cause-mortalityAssociated with amputationAcute limb ischemiaLimb-threatening ischemiaLower-extremity revascularizationCardiorenal benefitsCost-Effectiveness of Antithrombotic Therapies for Peripheral Arterial Disease
Dhanda U, Alameddine D, Schultz K, Tran L, Silva D, Slade M, Kabbani L, Guzman R, Leeds I, Ochoa Chaar C. Cost-Effectiveness of Antithrombotic Therapies for Peripheral Arterial Disease. Journal Of Vascular Surgery 2026 PMID: 41967727, DOI: 10.1016/j.jvs.2026.03.629.Peer-Reviewed Original ResearchDual antiplatelet therapyLower extremity revascularizationQuality-adjusted life yearsEvent-free survivalIncremental cost-effectiveness ratioCost-effectiveness ratioPeripheral arterial diseaseAntithrombotic therapyAdverse cardiovascular event-free survivalPatients treated with dual antiplatelet therapyWillingness-to-pay (WTP) thresholdArtery diseaseCardiovascular event-free survivalLimb-related outcomesWillingness-to-payKaplan-Meier analysisAdverse cardiovascular eventsFactor Xa inhibitorsAdverse limb event-free survivalAdverse limb eventsAntithrombotic treatmentAntiplatelet therapyBaseline characteristicsClinical outcomesXa inhibitorsSmoking cessation after Lower Extremity Revascularization in the Vascular Quality Initiative
Carter W, Schwartz A, Zwibelman H, Aboian E, Tonnessen B, Cardella J, Guzman R, Ochoa Chaar C. Smoking cessation after Lower Extremity Revascularization in the Vascular Quality Initiative. Journal Of Vascular Surgery 2026 PMID: 41825793, PMCID: PMC13208455, DOI: 10.1016/j.jvs.2026.03.006.Peer-Reviewed Original ResearchLower extremity bypassLower extremity revascularizationPeripheral vascular interventionsSmoking cessation effortsSmoking cessationCessation effortsPeripheral arterial diseaseCurrent smokersDisadvantaged neighborhoodsEndovascular lower extremity revascularizationSocioeconomically disadvantaged neighborhoodsHigher rates of adverse outcomesInfrainguinal bypassExtremity revascularizationProportion of smokersSurvival analysisRates of adverse outcomesLong-term outcomesVascular Quality InitiativePercentage of active smokersSociety for Vascular SurgeryLower-extremity revascularizationStop smokingHigher RatesSmoking status
Academic Achievements & Community Involvement
Clinical Care
Overview
Dr. Raul Guzman is chief of the division of vascular surgery and endovascular therapy at Yale New Haven Hospital. He is also surgeon-in-chief, vascular surgery at the Heart and Vascular Center for the Yale New Haven Health System.
Dr. Guzman joins Yale Medicine from Beth Israel Deaconess Medical Center and Harvard Medical School. Prior to moving to Boston, he spent the early portion of his career at Vanderbilt Medical Center in Nashville, Tennessee, where he served for several years as chief of vascular surgery at the Nashville VA Hospital.
He received his medical degree from Johns Hopkins University in Baltimore, MD. After completing his residency in general surgery, he completed research training in the cardiology branch of the National Heart, Lung, and Blood Institute at the National Institutes of Health (NIH) and subsequently completed a fellowship in vascular surgery at Stanford University Hospital.
He recently completed his term as a permanent member of the Bioengineering, Technology, and Surgical Sciences Study Section of the NIH. His clinical interests relate to patients who have diabetic vascular disease, peripheral artery disease, and preventing amputation. His research focuses on the role of arterial calcification in lower extremity ischemia.
Clinical Specialties
Vascular & Endovascular Surgery
Fact Sheets
Vascular Surgery
Learn More on Yale MedicinePeripheral Artery Disease (PAD)
Learn More on Yale MedicineAortic Aneurysm
Learn More on Yale MedicinePeripheral Vascular Disease (PVD)
Learn More on Yale Medicine
Yale Medicine News
News
News
- December 18, 2025
Yale Surgery Team Marks Milestone with 100th Complex Endovascular Aortic Repair
- December 12, 2024
Yale Vascular Surgery Launches Same-Day Dialysis Access Program
- December 12, 2024
Dr. Raul Guzman Receives the 2024 Dr. Walter E. Longo MD Award
- June 03, 2024
Vascular Innovates Sedation Model to Alleviate OR Capacity
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