Matthew Lawrence, MD, PhD
About
Biography
Dr. Lawrence is a co-founder of RxGen, a private preclinical research
organization that evaluates pharmakokinetics and emerging therapeutics.
Appointments
Comparative Medicine
Assistant Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- MD
- Yale School of Medicine (1999)
- PhD
- Stanford University (1995)
- BA
- Harvard College (1991)
- Resident
- Massachusetts Eye and Ear Infirmary
Research
Research at a Glance
Publications Timeline
A big-picture view of Matthew Lawrence's research output by year.
5Publications
25Citations
Publications
2009
Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug–drug interactions
Ward KW, Coon DJ, Magiera D, Bhadresa S, Struharik M, Lawrence MS. Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug–drug interactions. Xenobiotica 2009, 39: 266-272. PMID: 19280525, DOI: 10.1080/00498250802657718.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsDrug-drug interactionsAfrican green monkeysGreen monkeysPreclinical pharmacokinetic modelKetoconazole co-administrationCo-administration experimentsHuman oral exposureOral pharmacokinetic parametersNon-human primatesOral pharmacokinetic studyCo-administrationDrug interactionsOral exposurePharmacokinetic parametersPharmacokinetic resultsOral pharmacokineticsRhesus monkeysPharmacokinetic modelPharmacokinetic screeningPharmacokinetic studyErythromycinHuman exposureLidocainePropranololMonkeys
2008
Exploration of the African Green Monkey as a Preclinical Pharmacokinetic Model: Intravenous Pharmacokinetic Parameters
Ward KW, Coon DJ, Magiera D, Bhadresa S, Nisbett E, Lawrence MS. Exploration of the African Green Monkey as a Preclinical Pharmacokinetic Model: Intravenous Pharmacokinetic Parameters. Drug Metabolism And Disposition 2008, 36: 715-720. PMID: 18227143, DOI: 10.1124/dmd.107.019315.Peer-Reviewed Original ResearchCitations
2004
Ocular tissue permeabilities.
Lawrence MS, Miller JW. Ocular tissue permeabilities. International Ophthalmology Clinics 2004, 44: 53-61. PMID: 15211177.Peer-Reviewed Original Research
2000
Gene therapies that enhance hippocampal neuron survival after an excitotoxic insult are not equivalent in their ability to maintain synaptic transmission.
Dumas TC, McLaughlin JR, Ho DY, Lawrence MS, Sapolsky RM. Gene therapies that enhance hippocampal neuron survival after an excitotoxic insult are not equivalent in their ability to maintain synaptic transmission. Experimental Neurology 2000, 166: 180-9. PMID: 11031094, DOI: 10.1006/exnr.2000.7500.Peer-Reviewed Original ResearchLimitations in the neuroprotective potential of gene therapy with Bcl-2.
Phillips RG, Lawrence MS, Ho DY, Sapolsky RM. Limitations in the neuroprotective potential of gene therapy with Bcl-2. Brain Research 2000, 859: 202-6. PMID: 10719065.Peer-Reviewed Original Research
Get In Touch
Contacts
Mailing Address
Comparative Medicine
100 Deepwood Drive
Hamden, CT 06517
United States