Joseph Brancale, MD, PhD

Joseph Brancale is an internal medicine resident in the physician scientist pathway whose research focuses on uncovering the genetic mechanisms that drive rare and complex liver diseases. He received his PhD in the lab of Dr. Silvia Vilarinho. His prior work integrates in silico genomic discovery and single-cell approaches, in vitro systems such as iPSCs and organoids, and in vivo mouse modeling to connect genetic findings with functional biology. By combining computational analysis with experimental validation, he seeks to define how cellular pathways become disrupted in disease and to establish frameworks that can guide both diagnosis and therapeutic development in hepatology.