Guido J. Falcone, MD, ScD, MPH
Associate Professor of NeurologyCards
About
Titles
Associate Professor of Neurology
Academic Chief, Division of Neurocritical Care, Neurology; Director of Clinical Research in Neurocritical Care, Neurology; Training Director, Yale/AHA Bugher Center for Intracerebral Hemorrhage Research, Neurology; Staff Neurointensivist, Neurology
Biography
I am a Neurologist with subspecialty training in Neurocritical Care and Stroke, and an Epidemiologist with expertise in Population Genetics and Big Data. While on clinical duties, I treat critically ill patients that have sustained a significant neurological injury due to ischemic stroke, subarachnoid hemorrhage, intraparenchymal hemorrhage, traumatic brain injury, seizures, recent neurosurgery, decompensated neuromuscular diseases, and several others.
My research lies at the interphase of clinical neurology, neuroimaging, population genetics and genomic medicine. I am interested in understanding how common and rare genetic variation influences the occurrence, severity, functional outcome and recurrence of stroke, both hemorrhagic and ischemic. Genetic variants influencing these phenotypes can be used for numerous applications, including: (1) identification of novel biological mechanisms involved in causing stroke and determining its severity and outcome, (2) answering non-genetic epidemiological questions using gene mutations as instruments (in the statistical sense of the word), and (3) risk stratification of patients according to their genetic profile. Through the International Stroke Genetics Consortium, I work in close collaboration with numerous investigators interested in stroke genomics from around the world.
Appointments
Neurology
Associate Professor on TermPrimary
Other Departments & Organizations
- Center for Biomedical Data Science
- Center for Brain & Mind Health
- Center for Neuroepidemiology and Clinical Neurological Research
- Neurocritical Care & Emergency Surgery
- Neurology
- Yale Center for Genomic Health
- Yale Medicine
Education & Training
- Neurocritical Care Fellowship
- Harvard Medical School / Massachusetts General Hospital / Brigham and Women's Hospital
- ScD
- Harvard School of Public Health, Department of Epidemiology
- MPH
- Harvard School of Public Health, Quantitative Methods
- Neurology Residency
- F.L.E.N.I.
- MD
- University of Buenos Aires School of Medicine
Research
Publications
2025
APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, de Havenon A, Hawkes M, Gilmore E, Schwamm L, Sheth K, Gill T, Falcone G. APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban. JAMA Neurology 2025, 82 PMID: 40549373, PMCID: PMC12186128, DOI: 10.1001/jamaneurol.2025.0182.Peer-Reviewed Original ResearchRisk of intracranial hemorrhagePopulation-based studyYears of follow-up dataApo E4Cox proportional hazards modelsAPOE e4 alleleIntracranial hemorrhageRisk prediction scoreCerebral amyloid angiopathyClinical decision-makingProportional hazards modelAtrial fibrillationIncreased risk of ICHMultivariate Cox proportional hazards modelMain OutcomesIncident intracranial hemorrhageEuropean ancestryCohort studyInclusion criteriaHistory of ischemic strokeAmyloid angiopathyE4 variantHazards modelIncreased riskE4 alleleAcute Ischemic Stroke Risk Following Cardiac Interventions in the United States From 2016 to 2021
Koo A, Zhou L, Hameed I, Rivier C, Clocchiatti-Tuozzo S, Kamel H, Falcone G, Ney J, Sharma R, Matouk C, Yaghi S, Sheth K, de Havenon A. Acute Ischemic Stroke Risk Following Cardiac Interventions in the United States From 2016 to 2021. Neurology 2025, 105: e213766. PMID: 40493873, PMCID: PMC12165311, DOI: 10.1212/wnl.0000000000213766.Peer-Reviewed Original ResearchConceptsIntervention hospitalsSurvey weightsNon-Hispanic black ethnicityNIH Stroke ScaleStroke riskIschemic strokeFactors associated with ischemic strokeAssociated with female sexCardiac interventionsIschemic stroke riskIncidence of ischemic strokeVariables associated with riskRate of ischemic strokeNational Inpatient SampleHigh-risk populationDiagnosis-related groupsIntervention patientsCross-sectional cohortUnited StatesAcute ischemic stroke riskIn-hospital deathRisk of strokeSecondary analysisBlack ethnicityInpatient mortalityThe Brain Care Score and its associations with cardiovascular disease and cancer
Senff J, Rivier C, Tack R, Tan B, Kimball T, Brouwers H, Newhouse A, Fricchione G, Tanzi R, Yechoor N, Chemali Z, Anderson C, Rosand J, Falcone G, Singh S. The Brain Care Score and its associations with cardiovascular disease and cancer. Family Practice 2025, 42: cmaf034. PMID: 40464807, DOI: 10.1093/fampra/cmaf034.Peer-Reviewed Original ResearchConceptsLate-life depressionIncidence of cardiovascular diseaseCare scoresCardiovascular diseaseUK Biobank (UKBCases of cardiovascular diseaseRisk of dementiaHealth-related behaviorsIncident cardiovascular diseaseModifiable risk factorsCases of cancerCancer typesUKB participantsCox proportional hazards regression analysisProportional hazards regression analysisHazards regression analysisHealthy agingRisk factorsUKBDementiaRegression analysisFollow-upParticipantsAge-related brain diseasesBaselineDifferent Responses to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage
Clocchiatti-Tuozzo S, Rivier C, Qureshi A, Renedo D, Huo S, Matouk C, Petersen N, de Havenon A, Sheth K, Rabinstein A, Falcone G, Hawkes M. Different Responses to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage. Neurocritical Care 2025, 1-9. PMID: 40293696, DOI: 10.1007/s12028-025-02269-2.Peer-Reviewed Original ResearchRenal adverse eventsDeep intracerebral hemorrhageIntensive BP reductionRisk of renal adverse eventsRisk of HEHematoma expansionBP reductionATACH-2Intracerebral hemorrhageLobar intracerebral hemorrhageFunctional outcomesAntihypertensive Treatment of Acute Cerebral Hemorrhage IIAcute spontaneous intracerebral hemorrhageAcute intracerebral hemorrhageSpontaneous intracerebral hemorrhageAssociated with reduced riskUnfavorable functional outcomeBlood pressure reductionRandomized clinical trialsMultivariate logistic regression resultsPost hoc analysisAntihypertensive treatmentAdverse eventsClinical trialsIncreased riskPolygenic Resistance to Vascular Risk Factor Control in Stroke Survivors (S30.006)
Huo S, Rivier C, Clocchiatti-Tuozzo S, Renedo D, Torres-Lopez V, Sunmonu N, Petersen N, De Havenon A, Sheth K, Falcone G. Polygenic Resistance to Vascular Risk Factor Control in Stroke Survivors (S30.006). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000208802.Peer-Reviewed Original ResearchRacial Disparities in Mental Health Among Stroke Survivors in the REDUCE Study (P1-13.014)
Brigger H, Forman R, Peasley E, Johnson I, Smith J, Champagne A, Zabinska J, Falcone G, Sansing L, Arora R, Mena-Hurtado C, Okpala M, Bushnell C, Mullen M, Cohen J, Cohen D, De Havenon A, Messe S, Sheth K. Racial Disparities in Mental Health Among Stroke Survivors in the REDUCE Study (P1-13.014). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000210645.Peer-Reviewed Original ResearchIntegrated Genomic and Proteomic Drug Target Discovery for Vascular Dementia and Alzheimer’s Disease (P3-3.015)
Huo S, Clocchiatti-Tuozzo S, Magid-Bernstein J, Sharma R, Rangaraju S, Sansing L, Sheth K, Rivier C, Falcone G. Integrated Genomic and Proteomic Drug Target Discovery for Vascular Dementia and Alzheimer’s Disease (P3-3.015). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000211466.Peer-Reviewed Original ResearchIntegrated Genomic, Proteomic, and Transcriptomic Profiling Support Cathepsin-B as a Drug Repurposing Target in Cerebral Small Vessel Disease (S2.001)
Rivier C, Huo S, Clocchiatti-Tuozzo S, Renedo D, Sharma R, Payabvash S, Rangaraju S, Dong X, Sheth K, Sansing L, Falcone G. Integrated Genomic, Proteomic, and Transcriptomic Profiling Support Cathepsin-B as a Drug Repurposing Target in Cerebral Small Vessel Disease (S2.001). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000211788.Peer-Reviewed Original ResearchResilience and Recovery: Exploring the Spectrum of Physical Wellbeing in Ischemic and Hemorrhagic Stroke Survivors Through Diverse Therapy Experiences (P12-14.012)
Constantinescu S, Kitagawa R, Choksi D, DeLuca S, Rosand J, Sansing L, Sheth K, Egger E, Falcone G, Yechoor N, Forman R. Resilience and Recovery: Exploring the Spectrum of Physical Wellbeing in Ischemic and Hemorrhagic Stroke Survivors Through Diverse Therapy Experiences (P12-14.012). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000212058.Peer-Reviewed Original ResearchPolygenic Risk Factor Profiling and Risk of Intracerebral Hemorrhage In Patients with Atrial Fibrillation on Apixaban (P9-13.008)
Clocchiatti-Tuozzo S, Rivier C, Huo S, Gilmore E, Shoamanesh A, Kamel H, Murthy S, Ohno-Machado L, Sheth K, Gill T, Falcone G. Polygenic Risk Factor Profiling and Risk of Intracerebral Hemorrhage In Patients with Atrial Fibrillation on Apixaban (P9-13.008). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000212525.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
HIC ID2000031665RoleSub InvestigatorPrimary Completion Date12/01/2025Recruiting ParticipantsGenderBothAge18+ yearsRegulating Blood Pressure During Recovery from Intracerebral Hemorrhage and Ischemic Stroke (REDUCE)
HIC ID2000029811RoleSub InvestigatorPrimary Completion Date01/31/2025Recruiting ParticipantsGenderBothAge18+ yearsBrain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3)
HIC ID2000024956RoleSub InvestigatorPrimary Completion Date07/01/2023Recruiting ParticipantsGenderBothAge14+ yearsAnticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE)
HIC ID2000026409RolePrincipal InvestigatorPrimary Completion Date04/30/2028Recruiting ParticipantsGenderBothAge18+ yearsTransforming Acute Stroke Detection through Real Time Neurological Monitoring
HIC ID1605017863RoleSub InvestigatorPrimary Completion Date07/01/2017Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
Clinical Care
Overview
Guido Falcone, MD, ScD, MPH, is a critical care neurologist who treats patients with severe brain injuries from trauma, strokes, hemorrhages, and seizures, among other conditions. “I usually meet patients with these injuries immediately after they come to the hospital,” Dr. Falcone says. He also sees patients suffering from symptoms caused by neuromuscular diseases or complications from brain surgery.
“One important characteristic of our specialty is that many important decisions need to be made in those initial few minutes to hours,” Dr. Falcone says. “We also need to factor in the patient’s wishes, but often they are unconscious and cannot communicate.”
In those cases, Dr. Falcone relies on the patient’s family for guidance. “This can cause a tremendous amount of stress as they carry the huge responsibility of representing their loved ones,” he says.
Dr. Falcone keeps this additional stress in mind when he’s talking with the patient’s family about a diagnosis and what to expect next. “It’s very important for us to be honest and explain to them what we know and don’t know so that this uncertainty can be taken into consideration when we’re making a clinical decision,” he says. Dr. Falcone says he and his colleagues in the Neuroscience Intensive Care Unit (Neuro ICU) frequently update families on the status of a patient’s condition and progress.
“Something I came to realize after a few years in the field is that we help patients and families all the time. Sometimes, we help them get better,” Dr. Falcone says. “But another important part of our job is to give the very best end-of-life care, with the same approach we use when curing a disease or saving lives, if that is necessary.”
In his research, Dr. Falcone specializes in population genetics and genomic medicine, two related fields that involve analyzing large amounts of data and searching for different variants of genes that might influence human disease. He works with a team that uses information from across disciplines, such as neuroimaging data, for example, to conduct studies. “We want to use data to understand not just what causes disease, but also who is at high risk of developing it,” Dr. Falcone says. “Genes are such a powerful tool in patient care because our genetic information is constant from birth.”
Clinical Specialties
News & Links
News
- July 05, 2023
Cyprien Rivier, MD, MSc Wins ESOC Young Research Investigator Award in Stroke
- February 08, 2023
Santiago Clocchiatti-Tuozzo, MD Honored with Bernard J. Tyson Career Development Award and Stroke Underrepresented Racial and Ethnic Groups Travel Grant
- February 07, 2023
Daniela Renedo, MD Wins American Heart Association Stroke Basic Science Award
- January 31, 2023
Yale Study Links Genetics and Blood Pressure Control in Stroke Survivors
Get In Touch
Contacts
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Locations
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Academic Office
Fl 1, Ste 1E
New Haven, CT 06511
Business Office
203.785.6288Business Office Fax
203.737.4419Patient Care Locations
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