Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsDavid Glahn, PhD
Professor Adjunct of PsychiatryDownloadHi-Res Photo
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Titles
Professor Adjunct of Psychiatry
Professor of Psychology
Biography
Dr. David Glahn joined Yale’s Department of Psychiatry and the Olin Neuropsychiatry Research Center in 2008. He received his doctorate in clinical psychology from the University of Pennsylvania in 2000 and completed a post-doctoral fellowship at the University of California at Los Angeles. From 2002 to 2008, Glahn was faculty at the University of Texas Health Science Center San Antonio, where he created a psychiatric genetics and imaging research program.
The primary aim of Glahn’s laboratory is to discover genes that predispose affective and psychotic disorders like major depression, bipolar disorder and schizophrenia. To achieve this aim, he develops and applies neuroanatomic, functional neuroimaging, and neurocognitive endophenotypes in large-scale family-based studies. Glahn co-direct the Neurocognition, Neurocomputation and Neurogenetics (n3) Division of the Department of Psychiatry at Yale University Medical School, and the Affective Disorders and Psychosis (ADAPTING) laboratory at the Olin Neuropsychiatric Research Center. In this capacity, he supervises an 11-strong research team comprised of junior faculty, postdoctoral fellows and research assistants. Glahn collaborates with investigators locally at Yale/Olin, nationally and internationally in connection to neuroimaging, neurocognition and genomic research.
Last Updated on April 07, 2025.
Departments & Organizations
- Olin Neuropsychiatry Research Center
- Yale Global Mental Health Program
- Yale Ventures
Education & Training
- MA
- Yale University, Privatim (2015)
- Post-Doctoral Fellow
- University of California Los Angeles (2002)
- PhD
- University of Pennsylvania, Psychology (2000)
- MA
- University of Pennsylvania, Psychology (1997)
- BS
- Drexel University, Psychology (1993)
Research
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Overview
Medical Research Interests
Aging; Bipolar Disorder; Child Development; Depressive Disorder, Major; Genetics; Genetics, Behavioral; Neuroimaging; Neuropsychology; Psychiatry and Psychology; Schizophrenia
ORCID
0000-0002-4749-6977
Research at a Glance
Yale Co-Authors
Frequent collaborators of David Glahn's published research.
Publications Timeline
A big-picture view of David Glahn's research output by year.
Research Interests
Research topics David Glahn is interested in exploring.
Godfrey Pearlson, MA, MBBS
Vince Calhoun, PhD
John Krystal, MD
John D Murray, PhD
Alecia Dager, PhD
Hao Huang, MD, MPH
46Publications
396Citations
Schizophrenia
Neuroimaging
Child Development
Aging
Publications
2026
Gene × sex interactions on cognition in the Philadelphia neurodevelopmental cohort
Mollon J, Knowles E, Mathias S, Rodrigue A, Gur R, Peralta J, Weiner D, Robinson E, Raznahan A, Gur R, Blangero J, Almasy L, Glahn D. Gene × sex interactions on cognition in the Philadelphia neurodevelopmental cohort. Biology Of Sex Differences 2026, 17: 116. PMID: 42251438, PMCID: PMC13251074, DOI: 10.1186/s13293-026-00929-2.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsPhiladelphia Neurodevelopmental CohortCognitive measuresGeneral population sampleSex differencesNeurodevelopmental CohortCognitive abilitiesPenn Computerized Neurocognitive BatteryCognitive sex differencesComputerized Neurocognitive BatteryConfirmatory factor analysisEnvironmental varianceIndividuals aged 8Genetic factorsComposite domain scoresNeurocognitive batterySocial cognitionExecutive functionEpisodic memoryComplex cognitionCognitionSex interactionFactor analysisAged 8Magnitude of effectDomain scoresEvaluating psychosis-specific effects of trauma exposure in early-onset and adult-onset psychosis
Unzueta J, Mathias S, Lanzagorta N, Mollon J, Knowles E, Deaso E, Cadavid L, Brownstein C, D’Angelo E, Gonzalez-Heydrich J, Ramírez P, Sarmiento E, Bustamante C, Almasy L, Nicolini H, Pearlson G, Glahn D, Rodrigue A. Evaluating psychosis-specific effects of trauma exposure in early-onset and adult-onset psychosis. Psychological Medicine 2026, 56: e168. PMID: 42212570, PMCID: PMC13234531, DOI: 10.1017/s0033291726104401.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsTrauma exposurePsychiatric diagnosisSymptom severityGlobal functioningAssociated with greater symptom severityEffects of trauma exposurePoorer global functioningGreater symptom severityAdult-onset psychosisHigher trauma exposurePsychosis statusPsychiatric disordersTrauma-informed carePsychosisDiagnostic groupsEarly-onsetTrauma effectsCognitionGeneral populationTraumaGreater numbersAdult onsetPsychiatrySeverityDisordersStructural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder
Nabulsi L, Kang M, Jahanshad N, McPhilemy G, Martyn F, Haarman B, McDonald C, Hallahan B, O’Donoghue S, Stein D, Howells F, Scheffler F, Temmingh H, Glahn D, Rodrigue A, Pomarol-Clotet E, Vieta E, Radua J, Salvador R, Karuk A, Canales-Rodríguez E, Houenou J, Favre P, Polosan M, Pouchon A, Brambilla P, Bellani M, Mitchell P, Roberts G, Dannlowski U, Borgers T, Meinert S, Flinkenflügel K, Repple J, Leehr E, Grotegerd D, Hahn T, Wessa M, Phillips M, Teutenberg L, Kircher T, Straube B, Steinstraeter O, Stein F, Thomas-Odenthal F, Alexander N, Usemann P, Jansen A, Berk M, Dandash O, Parker N, Suo C, Thomopoulos S, Thompson P, Andreassen O, Ching C, Cannon D, Group E. Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder. Biological Psychiatry 2026 PMID: 42092437, DOI: 10.1016/j.biopsych.2026.04.020.Peer-Reviewed Original ResearchAltmetricConceptsBipolar disorderFrontolimbic connectivityGraph theoretical metricsNetwork alterationsStructural brain network alterationsReward-related circuitsIllness severityLonger illness durationBrain network alterationsGray matter abnormalitiesStructural connectivity studiesMagnetic resonance imagingWhite matter pathwaysDiffusion MRI scansNeurobiological markersAntipsychotic useManic episodesT1-weighted magnetic resonance imagingIllness durationPsychosis historySymptom severityControl participantsMedication effectsSpherical deconvolution tractographyLithium effects250. Natural Language Processing–Derived Semantic Perplexity in Childhood-Onset Psychosis
Deo A, Lando C, Carolan A, Fradkin Y, Silamongkol T, Carpenter E, Rosenkranz C, Ali A, Escoto A, McDonnell C, He R, Hinzen W, Graves W, Solis J, Barr W, Deaso E, Glahn D, Pato M, Zald D, Pato C. 250. Natural Language Processing–Derived Semantic Perplexity in Childhood-Onset Psychosis. Biological Psychiatry 2026, 99: s205-s206. DOI: 10.1016/j.biopsych.2026.03.484.Peer-Reviewed Original Research10. Low-Field MRI: A Tool for Detecting Cortical Abnormalities in Early-Onset Psychosis
Jalbrzikowski M, Choi S, Sathe S, Elder I, Shaw J, Glahn D. 10. Low-Field MRI: A Tool for Detecting Cortical Abnormalities in Early-Onset Psychosis. Biological Psychiatry 2026, 99: s79. DOI: 10.1016/j.biopsych.2026.03.190.Peer-Reviewed Original Research290. Neuroimaging Summary Scores Predict Trajectories of Psychotic-Like Experiences in Young Adolescents
Cooper R, Sahasrabudhe R, Glahn D, Jalbrzikowski M. 290. Neuroimaging Summary Scores Predict Trajectories of Psychotic-Like Experiences in Young Adolescents. Biological Psychiatry 2026, 99: s224. DOI: 10.1016/j.biopsych.2026.03.524.Peer-Reviewed Original ResearchPD02-13 ELEVATED PSYCHIATRIC COMORBIDITY AND POLYGENIC RISK FOR DEPRESSION IN INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME
Brownstein C, Estrella E, Jain A, Weisenhahn M, Fernandes M, Deaso E, Barbour K, Sun L, Glahn D. PD02-13 ELEVATED PSYCHIATRIC COMORBIDITY AND POLYGENIC RISK FOR DEPRESSION IN INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME. Journal Of Urology 2026, 215: e16. DOI: 10.1097/01.ju.0001191260.74872.fd.13.Peer-Reviewed Original ResearchSocial Isolation and Aging health in Schizophrenia spectrum disorders (SIAS): study protocol for a multinational longitudinal study
Koster M, van der Pluijm M, Baldwin H, Greenburgh A, King D, Arnold C, Lopez-Morinigo J, Underwood S, Larrauri C, Racher M, Glahn D, Harvey P, Sandin S, Stevens M, Pearlson G, Arango C, Dazzan P, Morgan C, de Haan L, Reichenberg A, Velthorst E. Social Isolation and Aging health in Schizophrenia spectrum disorders (SIAS): study protocol for a multinational longitudinal study. BMC Psychiatry 2026, 26: 324. PMID: 41808086, PMCID: PMC13085470, DOI: 10.1186/s12888-026-07936-y.Peer-Reviewed Original ResearchAltmetricConceptsLong-term health impactsFirst-degree relativesSocial isolationPremature mortalitySchizophrenia spectrum disordersElevated risk of premature mortalityRisk of premature mortalityGeneral populationElevated riskUnhealthy lifestyle behaviorsImpact of social isolationAdverse health outcomesLarge-scale follow-up studiesFollow-up assessmentAssociated with older ageLifestyle behaviorsDigital phenotyping dataHealth outcomesPhysical comorbiditiesPoor dietAging healthHealth conditionsNumerous health conditionsExcess mortalityOverall healthPsychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis
King S, O’Connor J, Corley E, Tronchin G, Fontana E, Nabulsi L, Kang M, Radua J, Hallahan B, Abé C, Alda M, Alnæs D, Alonso-Lana S, Amoretti S, Bauer J, Benedetti F, Berger K, Berk M, Bøen E, Böhnlein J, Boye B, Bravi B, Canales-Rodríguez E, Dannlowski U, Demro C, Di Giorgio A, Diaz-Zuluaga A, Elvsåshagen T, Favre P, Erwin-Grabner T, Forte M, Fullerton J, Furlong L, Rossell S, Glahn D, Goldstein B, Gotlib I, Goya-Maldonado R, Green M, Grotegerd D, Gruber O, Haarman B, Hahn T, Hajek T, Hater L, Hermesdorf M, Houenou J, Howells F, Karantonis J, Kennedy K, Kircher T, Klahn A, Konowski M, Krämer B, Lahud E, Kuplicki R, Landén M, López-Jaramillo C, MacIntosh B, Meinert H, Meinert S, Melloni E, Mitchell P, Mwangi B, Nenadić I, Overs B, Parker N, Pearlson G, Pomarol-Clotet E, Prisciandaro J, Quidé Y, Roberts G, Rodrigue A, Rodríguez-Cano E, Rauer L, Sacchet M, Salvador R, Sambataro F, Satterthwaite T, Savitz J, Scheffler F, Schürmeyer N, Shen C, Sim K, Soares J, Solanes A, Soeiro-de-Souza M, Sponheim S, Stein D, Stein F, Temmingh H, Teutenberg L, Thomopoulos S, Urosevic S, Van Rheenen T, Vieta E, Westlye L, Wolf D, Wu M, Yatham L, Zunta-Soares G, Cannon D, Thompson P, Andreassen O, Ching C, McDonald C. Psychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis. Molecular Psychiatry 2026, 31: 2941-2953. PMID: 41540091, PMCID: PMC13099646, DOI: 10.1038/s41380-025-03432-z.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSubcortical brain volumesMonoamine receptor antagonistsBipolar disorderPsychotropic medicationsBrain volumeSubcortical volumesMedical statusAssociated with smaller hippocampalMedication-free patientsAntipsychotic medicationPutamen volumeHippocampal volumeModeration analysisThalamic volumeBD patientsMega-AnalysisLithium useLongitudinal researchInconsistent findingsMild ventricular enlargementReceptor antagonistLinear mixed-effectsLarger ventriclesValproateMRI studies
2025
Genome-wide association study identifies novel variants in olfactory, vitamin A, vitamin B, and cadherin pathways associated with learning and memory
Hopkins L, Avgan N, Sutherland H, Fernandez F, Knowles E, Haupt L, Blangero J, Glahn D, Shum D, Lea R, Griffiths L. Genome-wide association study identifies novel variants in olfactory, vitamin A, vitamin B, and cadherin pathways associated with learning and memory. Scientific Reports 2025, 16: 2911. PMID: 41413636, PMCID: PMC12830837, DOI: 10.1038/s41598-025-32828-8.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCognitive phenotypesVerbal learningAssociation studiesIntronic variantsMultiple cognitive domainsGenetic basisGenome wide significant associationComprehensive test batteryCognitive performance assessmentContribution of genetic variationCorrelating test scoresProspective memoryRetrospective memoryCognitive domainsTest batteryLearned discriminationCadherin pathwaysHuman cognitionSynonymous variantsGenetic variationUTR variantsTest scoresGenetic associationMemory
Academic Achievements & Community Involvement
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Activities
activity Yale Scholar Awards Committee
05/03/2015 - PresentCommitteesMemberDetailsMemberactivity Yale Center for Clinical Investigation
04/30/2015 - PresentCommitteesMemberDetailsRevieweractivity Burlingame Award Selection Committee
04/30/2000 - PresentCommitteesMemberDetailsMemberactivity Monash Biomedical Imaging Center, Monash University
04/30/2012 - PresentCommitteesMemberDetailsMember, External Advisory Boardactivity Human Brain Mapping (Journal)
04/30/2015 - PresentPublic ServiceMemberDetailsEditorial Board
Honors
honor Joel Elkes Research Award
12/12/2016International AwardAmerican College of Neuropsychopharmacology (ACNP)DetailsUnited Stateshonor Independent Investigator Award
01/01/2013International AwardNational Alliance for Research on Schizophrenia and Depression (NARSAD)DetailsUnited Stateshonor Theodore Reich Research Award
05/01/2011International AwardInternational Society for Psychiatric GeneticsDetailsUnited Stateshonor A.E. Bennett Neuropsychiatric Research Award
05/01/2010International AwardSociety for Biological PsychiatryDetailsUnited Stateshonor Young Investigator Award
05/02/2005International AwardNational Alliance for Research on Schizophrenia and Depression (NARSAD)DetailsUnited States
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