Carlos Grilo, PhD
Professor of Psychiatry and of PsychologyCards
About
Titles
Professor of Psychiatry and of Psychology
Director, Program for Obesity, Weight and Eating Research (POWER) at Yale, Psychiatry
Biography
Dr. Grilo is an internationally-recognized expert on eating disorders, obesity, and manifestations of disordered eating. His secondary clinical-research interests include psychopathology, personality disorders, addictions, and the sociocultural contexts of functioning. Dr. Grilo’s current work focuses on performing controlled treatment studies testing behavioral, cognitive-behavioral, guided-self-help scalable treatments, and pharmacological interventions for eating/weight disorders in diverse patient groups/settings, including bariatric surgery. Dr. Grilo’s current RCTs include adaptive “SMART” stepped-care designs for binge-eating disorder and obesity. His current collaborative work is interdisciplinary, integrating laboratory and neurobiological methods, extending across diverse settings and patient groups, and includes epidemiological and longitudinal outcome studies, with an increasing emphasis on health disparities and stigma.
Dr. Grilo has been continuously funded by the National Institutes of Health (NIH) for 30 years and has served as Principal Investigator on 20 NIH grants. Dr. Grilo received two K24 Mid-Career Investigator Awards in Eating/Weight Disorders from the NIH/NIDDK, which reflect his longstanding commitment to training and mentoring and in collaborative clinical-research activities. Dr. Grilo’s involvement with the psychology training program dates back to 1993-2000, when he coordinated the pre-doctoral internship and postdoctoral training programs at the Yale Psychiatric Institute while serving as Director of Psychology.
Dr. Grilo currently serves on the editorial boards of 10 professional journals, including the Journal of Consulting and Clinical Psychology and the American Psychologist. Dr. Grilo has published over 510 peer-reviewed journal articles (“h” index of 90 with over 29,500 citations on SCOPUS; "discipline-H" index of 119 with 45,800 citations on Research.com), 25 chapters, and two books on eating and weight disorders.
In his capacity as Director of POWER, Dr. Grilo provides leadership of this entirely grant-funded clinical-research and training program focused on eating/weight disorders. POWER provides research training to students/trainees (undergraduate, graduate, pre-doctoral, post-doctoral, and junior faculty levels) with interests in academic careers; the primary focus is on post-doctoral training.
Appointments
Psychiatry
ProfessorPrimary
Other Departments & Organizations
- Obesity Research Working Group
- Program for Obesity, Weight and Eating Research (POWER) at Yale
- Psychiatry
- Psychology Section
- Stress & Addiction Clinical Research Program
- Yale Medicine
- Yale Stress Center
- Yale Ventures
Education & Training
- Postdoc
- Clinical Psychology Yale University (1992)
- Internship
- Clinical Psychology Harvard Medical School (1992)
- Fellowship
- Clinical Psychology Harvard Medical School (1992)
- PhD
- University of Pittsburgh (1991)
Research
Publications
2025
Transcranial Magnetic Stimulation for Reducing Food Reinforcement in Patients Pursuing Metabolic Bariatric Surgery: A Within-Participants Sham-Controlled Pilot Trial
Bond D, Papasavas P, Raynor H, Grilo C, Wu Y, Kang D, Steele V. Transcranial Magnetic Stimulation for Reducing Food Reinforcement in Patients Pursuing Metabolic Bariatric Surgery: A Within-Participants Sham-Controlled Pilot Trial. Obesity Surgery 2025, 1-4. PMID: 40550967, DOI: 10.1007/s11695-025-07987-2.Peer-Reviewed Original ResearchRepetitive transcranial magnetic stimulationFood reinforcementFood rewardTranscranial magnetic stimulationLeft dorsolateral prefrontal cortexSham-rTMSDorsolateral prefrontal cortexConsume palatable foodRepetitive transcranial magnetic stimulation effectsMagnetic stimulationRepetitive transcranial magnetic stimulation protocolMetabolic bariatric surgeryNon-invasive brain stimulation techniqueBrain stimulation techniquesPrefrontal cortexPalatable foodWithin-participantsSham-controlled pilot trialValue of foodPost-rTMSChange scoresTest daysRisk of over-Bariatric surgeryBehavioral aspectsIs there harm in behavioral weight loss for binge-eating disorder: Controlled comparison to cognitive behavioral therapy
Grilo C, Yurkow S, White M, Lydecker J, Ivezaj V. Is there harm in behavioral weight loss for binge-eating disorder: Controlled comparison to cognitive behavioral therapy. General Hospital Psychiatry 2025, 96: 72-74. PMID: 40543449, DOI: 10.1016/j.genhosppsych.2025.06.005.Peer-Reviewed Original ResearchRandomized Controlled Trial of Weight Management Versus Weight Management With Concurrent Cognitive‐Behavioral Therapy for Binge‐Eating Disorder in US Veterans With High Weight
Masheb R, Buta E, Snow J, Munro L, Lawless M, Abel E, McWain N, Marsh A, Cary A, Grilo C, Raffa S, Ruser C. Randomized Controlled Trial of Weight Management Versus Weight Management With Concurrent Cognitive‐Behavioral Therapy for Binge‐Eating Disorder in US Veterans With High Weight. International Journal Of Eating Disorders 2025 PMID: 40485646, DOI: 10.1002/eat.24476.Peer-Reviewed Original ResearchDSM-5 binge-eating disorderBinge-eating disorderDSM-5Cognitive-behavioral therapyEating-disorder treatmentRemission rateUS military veteransBinge-eating frequencyMilitary veteransCBTVeteran populationShape-relatedVeteransWeight managementPost-treatmentWeight management programUS veteransMixed-effects modelsDisordersRandomized controlled trialsClinical Trials Registry numberPsychopathologyBinge-eatingWeight lossClinical guidanceIs there harm in behavioral lifestyle weight management for binge-eating disorder in patients with obesity: Findings from a randomized controlled trial
Grilo C, Ivezaj V, Yurkow S, Lydecker J. Is there harm in behavioral lifestyle weight management for binge-eating disorder in patients with obesity: Findings from a randomized controlled trial. Journal Of Psychosomatic Research 2025, 195: 112169. PMID: 40516275, DOI: 10.1016/j.jpsychores.2025.112169.Peer-Reviewed Original ResearchEating-disorder psychopathologyBinge-eating disorderIncreased symptomsSymptoms of binge eatingRandomized controlled trialsBinge-eating frequencyBinge eatingPsychopathologyRandomized to placeboBinge-eatingWeight managementPlaceboHeterogeneity of outcomesDisordersParticipantsPosttreatmentSecondary analysisFrequency of casesSymptomsClinical contextIndividual levelObesityControlled trialsSmall magnitudePatientsPreferences for Lisdexamfetamine vs Cognitive-Behavioral Therapy for Binge-Eating Disorder: Correlates and Outcomes.
Yurkow S, Ivezaj V, Pittman B, Grilo C. Preferences for Lisdexamfetamine vs Cognitive-Behavioral Therapy for Binge-Eating Disorder: Correlates and Outcomes. The Journal Of Clinical Psychiatry 2025, 86 PMID: 40338285, DOI: 10.4088/jcp.24m15552.Peer-Reviewed Original ResearchConceptsBinge-eating disorderTreatment preferencesModerate treatment outcomePatient treatment preferencesCognitive-behavioral therapyEffects of treatment preferenceTest main effectsCognitive-behavioralNo significant interaction effectsInteraction effectsBehavioral therapySignificant interaction effectCBTModerate outcomeEfficacious treatmentMain effectLisdexamfetamineTreatment outcomesParticipants' preferencesEffective interventionsEffects of treatmentDisordersRandomized controlled trialsNo preferenceLDXLifestyle behavioral weight‐loss treatment for binge‐eating disorder in patients with obesity: where's the harm?
Yurkow S, Ivezaj V, Grilo C. Lifestyle behavioral weight‐loss treatment for binge‐eating disorder in patients with obesity: where's the harm? Obesity 2025, 33: 1058-1066. PMID: 40342236, PMCID: PMC12119222, DOI: 10.1002/oby.24289.Peer-Reviewed Original ResearchConceptsBinge-eating disorderED psychopathologyWeight loss treatmentExacerbate eating disordersBinge-eating frequencyPsychopathology scoresBinge eatingSymptoms of binge eatingBehavioral weight loss treatmentIncreased symptomsEating disordersPsychopathologyFollow-upDisordersPosttreatmentHeterogeneity of outcomesEatingSecondary analysisFrequency of casesCoexisting obesityClinical contextParticipantsIndividual levelBingeObesityRapid response to behavioral/pharmacological obesity treatments for binge‐eating disorder predicts better clinical outcomes
Lydecker J, Gueorguieva R, Grilo C. Rapid response to behavioral/pharmacological obesity treatments for binge‐eating disorder predicts better clinical outcomes. Obesity 2025, 33: 1067-1075. PMID: 40265670, DOI: 10.1002/oby.24292.Peer-Reviewed Original ResearchConceptsBinge-eating disorderBinge-eating remissionEating-disorder psychopathologyAssociated with greater reductionsObesity treatmentCo-occurring obesityBinge-eating frequencyClinical trial testingBehavioral therapyNon-rapid responseGreater reductionsPercent weight lossNaltrexone/bupropionRandomized clinical trial testingDisordersPrognostic significanceParticipantsPosttreatmentClinical characteristicsPrognostic indicatorClinical outcomesMetabolic outcomesResponse effectMetabolic variablesObesity interventionsRepetitive transcranial magnetic stimulation modulates neural correlates of reward in patients pursuing metabolic bariatric surgery: results from a within-participant sham-controlled pilot study
Steele V, Kang D, Papasavas P, Raynor H, Grilo C, Wu Y, Bond D. Repetitive transcranial magnetic stimulation modulates neural correlates of reward in patients pursuing metabolic bariatric surgery: results from a within-participant sham-controlled pilot study. Brain Stimulation 2025, 18: 521-522. DOI: 10.1016/j.brs.2024.12.894.Peer-Reviewed Original Research
2024
Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial
Grilo C, Ivezaj V, Tek C, Yurkow S, Wiedemann A, Gueorguieva R. Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial. American Journal Of Psychiatry 2024, 182: 209-218. PMID: 39659158, PMCID: PMC11786997, DOI: 10.1176/appi.ajp.20230982.Peer-Reviewed Original ResearchCognitive-behavioral therapyBinge-eating disorderEffectiveness of cognitive-behavioral therapyBinge-eating remission ratesEating-disorder psychopathologyCognitive behavioral therapyEvidence-based treatmentsRemission ratePercent weight lossHigher remission ratesBinge-eating frequencyBehavioral therapyPosttreatment assessmentLisdexamfetamineRandomized controlled trialsHeightened ratesCostly public health problemIntention-to-treat ratesFunctional impairmentWeight lossControlled trialsDisordersPosttreatmentIndividualized treatmentMixed modelsThe Impact of Body Contouring Following Bariatric Surgery: A Prospective Examination of Psychosocial and Medical Impairment
Ivezaj V, Alperovich M, Price G, Dunford A, Metzler A, Grilo C. The Impact of Body Contouring Following Bariatric Surgery: A Prospective Examination of Psychosocial and Medical Impairment. Aesthetic Plastic Surgery 2024, 49: 269-276. PMID: 39402193, DOI: 10.1007/s00266-024-04427-x.Peer-Reviewed Original ResearchAssociated with heightened levelsBariatric surgeryFollow-up assessmentMeasures of impairmentLoose skinPsychosocial impairmentFollow-upPsychosocial concernsLevel of Evidence IIThis journalHeightened levelsPsychological concernsEvidence-Based Medicine ratingsSkin concernsClinical attentionDepressionImpairmentLevel of evidenceBCS patientsProspective examinationContouring surgerySurgeryConclusionsOver halfWeight lossBody contouringEvidence-based
Clinical Trials
Current Trials
Treatments to Treat Loss-of-Control Eating and Improve Weight Outcomes after Bariatric Surgery
HIC ID2000029057RolePrincipal InvestigatorPrimary Completion Date11/30/2027Recruiting ParticipantsCognitive-Behavioral Therapy for Girls Who Experienced Weight-related Bullying
HIC ID2000028551RoleSub InvestigatorPrimary Completion Date08/31/2022Recruiting ParticipantsGenderFemaleAge11 years - 17 yearsTeen Binge Eating Study
HIC ID2000024926RoleSub InvestigatorPrimary Completion Date02/28/2020Recruiting ParticipantsGenderBothAge13 years - 17 years
News
News
- June 10, 2025Source: International Journal of Eating Disorders
Randomized Controlled Trial of Weight Management Versus Weight Management With Concurrent Cognitive-Behavioral Therapy for Binge-Eating Disorder in U.S. Veterans With High Weight
- February 25, 2025
Grilo Tops Published Scholar Rankings in Field of Eating Disorders
- December 11, 2024Source: The American Journal of Psychiatry
Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial
- October 24, 2024Source: Cambridge University Press
Lisdexamfetamine Maintenance Treatment for Binge-Eating Disorder Following Successful Treatments
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