Greg Rhee, PhD, FACE
Associate Professor Adjunct in PsychiatryCards
Contact Info
About
Titles
Associate Professor Adjunct in Psychiatry
Biography
Greg Rhee, PhD, FACE, is Associate Professor of Medicine (Psychiatry) and Public Health (Epidemiology and Biostatistics). He is a pharmaco-epidemiologist and mental health services researcher studying access to care, quality of care, and clinical and patient-reported outcomes in patients with psychiatric and/or substance use disorders. His current research focuses on mood disorders, dementias, and suicide/suicidal behaviors as well as cannabis and opioids.
As an accredited professional statistician (PStat®) certified by the American Statistical Association, his expertise is grounded in (1) population-based observational studies using large databases; (2) systematic reviews and meta-analyses of existing studies; and (3) analyses of clinical trial data. In particular, he has extensive knowledge and experience with administrative claims data (e.g., Medicare and Medicaid), national health and healthcare survey data, and other data sources including electronic health records (e.g., Epic® database from Yale-New Haven Health), RCT data, and mortality data. He also investigates long-term comparative effectiveness and cost-effectiveness of pharmacological and non-pharmacological interventions for psychiatric and/or substance use disorders.
He has 250+ peer-reviewed research articles published in highly respected medical, psychiatric, and healthcare policy journals, such as Lancet, Lancet Neurology, JAMA, JAMA Psychiatry, and American Journal of Psychiatry. He has also been a successful Principal Investigator or Co-Investigator on multiple research projects funded by federal agencies, including Agency for Healthcare Research and Quality (AHRQ), Food and Drug Administration (FDA), and National Institutes of Health (NIH).
Outside Yale Psychiatry, he also serves as an Investigator at the VA Connecticut Healthcare System VISN 1 MIRECC and as a Senior Investigator at the Institute for Health Metrics and Evaluation (IHME).
Departments & Organizations
Education & Training
- NIH Postdoctoral Fellowship
- Yale University School of Medicine (2019)
- PhD
- University of Minnesota, Twin Cities (2017)
- MA
- The University of Chicago (2011)
- AB
- Emory University (2008)
Research
Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0003-4961-3361
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Joseph Ross, MD, MHS
Samuel Wilkinson, MD
Robert Rosenheck, MD
John Havlik, MD, MBA
Peter Jongho Na, MD, MPH
Sina Nikayin, MD
Substance-Related Disorders
Mental Disorders
Psychotropic Drugs
Delivery of Health Care
Publications
2025
Making Progress in Clinical Trials for Suicide Prevention: A Review.
Wilkinson ST, Bryan CJ, Alphs LD, Canuso CM, Ostacher MJ, Price RB, Bloch MH, Zarate CA, Rhee TG. Making Progress in Clinical Trials for Suicide Prevention: A Review. JAMA Psychiatry 2025 PMID: 39937491, DOI: 10.1001/jamapsychiatry.2024.4810.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsClinical Effectiveness of Electroconvulsive Therapy for Psychotic vs Nonpsychotic Depression: A Cohort Study.
Kelkar R, Liu GC, Goodman MS, Al-Hashemi A, Rhee TG, Blumberger DM, Kaster TS. Clinical Effectiveness of Electroconvulsive Therapy for Psychotic vs Nonpsychotic Depression: A Cohort Study. J Clin Psychiatry 2025, 86 PMID: 39898922, DOI: 10.4088/JCP.24m15399.Peer-Reviewed Original ResearchKetamine vs Electroconvulsive Therapy in the Management of Treatment-Resistant Depression: Do We Need More Data?
Rhee TG, Shim SR, Davoudian PA, Espinoza RT, McIntyre RS. Ketamine vs Electroconvulsive Therapy in the Management of Treatment-Resistant Depression: Do We Need More Data? J Clin Psychiatry 2025, 86 PMID: 39898891, DOI: 10.4088/JCP.24br15655.Peer-Reviewed Original ResearchTrends in depressive symptoms among high school students with and without health-risk behaviors in the United States: A population-based study.
Bommersbach TJ, Olfson M, Rhee TG. Trends in depressive symptoms among high school students with and without health-risk behaviors in the United States: A population-based study. Lancet Reg Health Am 2025, 42: 101000. PMID: 39906085, DOI: 10.1016/j.lana.2025.101000.Peer-Reviewed Original Research
2024
National Trends in and Concentration of Industry Payments to U.S. Psychiatrists, 2015-2021.
Havlik J, Ososanya L, Tang D, Wahid S, Ross J, Rhee T. National Trends in and Concentration of Industry Payments to U.S. Psychiatrists, 2015-2021. Psychiatric Services 2024, appips20240218. PMID: 39439279, DOI: 10.1176/appi.ps.20240218.Peer-Reviewed Original ResearchEfficacy and Safety of Ketamine/Esketamine in Bipolar Depression in a Clinical Setting.
Santucci M, Ansari M, Nikayin S, Radhakrishnan R, Rhee T, Wilkinson S. Efficacy and Safety of Ketamine/Esketamine in Bipolar Depression in a Clinical Setting. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39361411, DOI: 10.4088/jcp.24m15376.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsBipolar depressionAcute seriesRisk of affective switchDiagnosis of bipolar depressionRefractory bipolar depressionAcute phaseMADRS scoreAffective switchIntranasal esketamineManic episodesBipolar disorderCohort of patientsAttending psychiatristsSource of morbidityEsketamineSample of patientsIV ketamineMaintenance treatmentDepressionClinical responseHeightened riskClinical outcomesMania/hypomaniaKetamineKetamine/esketamineElectroencephalography (EEG) spectral signatures of selective serotonin reuptake inhibitors (SSRIs), selective norepinephrine reuptake inhibitors (SNRIs) and vortioxetine in major depressive disorder: A systematic review
Le G, Wong S, Lu A, Vasudeva S, Gill H, Badulescu S, Portelles D, Zheng Y, Teopiz K, Meshkat S, Kwan A, Ho R, Rhee T, Rosenblat J, Mansur R, McIntyre R. Electroencephalography (EEG) spectral signatures of selective serotonin reuptake inhibitors (SSRIs), selective norepinephrine reuptake inhibitors (SNRIs) and vortioxetine in major depressive disorder: A systematic review. Journal Of Affective Disorders 2024, 368: 798-819. PMID: 39299586, DOI: 10.1016/j.jad.2024.09.081.Peer-Reviewed Original ResearchConceptsReuptake inhibitorsDepressive disorderPathophysiology of depressive disordersSystematic reviewAssociated with SSRIsClass of SSRIsNorepinephrine reuptake inhibitorsDoses of antidepressantsSerotonin reuptake inhibitorsFDA-approved agentsVortioxetine treatmentBlock reuptakeAntidepressant exposureSerotonin transporterSNRISSRIsVortioxetineDatabase inceptionConverging evidenceFunctional connectivitySerotoninNeural activityElectroencephalography signaturesStudy investigated changesInhibitorsAssociation between rumination, suicidal ideation and suicide attempts in persons with depressive and other mood disorders and healthy controls: A systematic review and meta-analysis
Le G, Wong S, Au H, Badulescu S, Gill H, Vasudeva S, Teopiz K, Rhee T, Ho R, Kwan A, Mansur R, Rosenblat J, McIntyre R. Association between rumination, suicidal ideation and suicide attempts in persons with depressive and other mood disorders and healthy controls: A systematic review and meta-analysis. Journal Of Affective Disorders 2024, 368: 513-527. PMID: 39303880, DOI: 10.1016/j.jad.2024.09.118.Peer-Reviewed Original ResearchConceptsSuicidal ideationMood disordersPsychiatric disordersLifetime history of suicide attemptsHealthy controlsHistory of suicide attemptsMeasures of ruminationSuicide attempt historyDiagnosed mood disorderTransdiagnostic associationsAttempt historyDepressive disorderNeurobiological substratesSuicide completersLifetime historyGeneral cognitionSuicide attemptsMeta-analysisIdeationSystematic reviewMoodClinically meaningful associationsSuicideResearch vistasFunctional impairmentAssociation between cognitive functioning, suicidal ideation and suicide attempts in major depressive disorder, bipolar disorder, schizophrenia and related disorders: A systematic review and meta-analysis
Le G, Wong S, Haikazian S, Johnson D, Badulescu S, Kwan A, Gill H, Di Vincenzo J, Rosenblat J, Mansur R, Teopiz K, Rhee T, Ho R, Liao S, Cao B, Schweinfurth-Keck N, Vinberg M, Grande I, Phan L, d'Andrea G, McIntyre R. Association between cognitive functioning, suicidal ideation and suicide attempts in major depressive disorder, bipolar disorder, schizophrenia and related disorders: A systematic review and meta-analysis. Journal Of Affective Disorders 2024, 365: 381-399. PMID: 39168166, DOI: 10.1016/j.jad.2024.08.057.Peer-Reviewed Original ResearchConceptsBipolar disorderCognitive functionSchizoaffective disorderDepressive disorderExecutive functionMental disordersMeasures of cognitive functionSelf-injurious behaviorTreatable mental disorderGlobal executive functioningEffect size of associationSuicidal ideation/suicide attemptTransdiagnostic associationsSize of associationEmotional inhibitionWorking memoryNegative associationCognitive measuresNeurocognitive deficitsSuicidal ideationSuicide riskCognitive disturbancesImpulse controlProcessing speedMDDPreclinical and clinical efficacy of kappa opioid receptor antagonists for depression: A systematic review
Wong S, Le G, Vasudeva S, Teopiz K, Phan L, Meshkat S, Kwan A, Rhee T, Ho R, Choi H, Cao B, Rosenblat J, McIntyre R. Preclinical and clinical efficacy of kappa opioid receptor antagonists for depression: A systematic review. Journal Of Affective Disorders 2024, 362: 816-827. PMID: 39019223, DOI: 10.1016/j.jad.2024.07.030.Peer-Reviewed Original ResearchConceptsMajor depressive disorderKappa-opioid receptorsKappa-opioid receptor antagonistConventional antidepressantsOpioid receptor antagonistReceptor antagonistMeasures of anhedoniaClinical trialsPhase 3 pivotal trialsEarly stages of clinical trialsMu-opioid receptorsPhase 3 studyClinically-relevant dosesStages of clinical trialsDepressive disorderSystematic reviewDepressive symptomsMu-opioidOpioid receptorsAntidepressantsAdjunctive therapyClinical efficacyAdverse eventsAticaprantResearch vistas
Academic Achievements & Community Involvement
activity Journal of Clinical Psychiatry
Journal ServiceEditorial Board MemberDetails06/01/2022 - Presentactivity Depression and Anxiety
Journal ServiceAssociate EditorDetails10/01/2022 - Presentactivity American Journal of Geriatric Psychiatry
Journal ServiceEditorial Board MemberDetails2023 - Presentactivity National Institutes of Health Center for Scientific Review (CSR) - Study Section
Peer Review Groups and Grant Study SectionsCommittee MemberDetails2023 - Presenthonor Delta Omega Honorary Society in Public Health
International AwardDelta Omega (Faculty Mentor)Details05/05/2023
News
News
- February 21, 2025Source: JAMA Psychiatry
Making Progress in Clinical Trials for Suicide Prevention: A Review
- January 23, 2025Source: The Lancet Regional Health - Americas
Trends in Depressive Symptoms Among High School Students With and Without Health-Risk Behaviors in the United States: A Population-Based Study
- October 24, 2024Source: Psychiatric Services
National Trends in and Concentration of Industry Payments to U.S. Psychiatrists, 2015–2021
- October 02, 2024
Bipolar Disorder Patients Respond to Ketamine, Esketamine Treatment
Get In Touch
Contacts
Locations
E.S. Harkness Memorial Hall, Building A
Academic Office
367 Cedar Street, Rm 308
New Haven, CT 06510