Dunhui Li
Associate Research ScientistCards
About
Research
Publications
2025
A personalised and comprehensive approach is required to suppress or replenish SNCA for Parkinson’s disease
Li D, Yau W, Chen S, Wilton S, Mastaglia F. A personalised and comprehensive approach is required to suppress or replenish SNCA for Parkinson’s disease. Npj Parkinson's Disease 2025, 11: 42. PMID: 40038287, PMCID: PMC11880543, DOI: 10.1038/s41531-025-00887-3.Peer-Reviewed Original Research
2024
Controversies and insights into PTBP1-related astrocyte-neuron transdifferentiation: neuronal regeneration strategies for Parkinson’s and Alzheimer’s disease
McDowall S, Bagda V, Hodgetts S, Mastaglia F, Li D. Controversies and insights into PTBP1-related astrocyte-neuron transdifferentiation: neuronal regeneration strategies for Parkinson’s and Alzheimer’s disease. Translational Neurodegeneration 2024, 13: 59. PMID: 39627843, PMCID: PMC11613593, DOI: 10.1186/s40035-024-00450-9.Peer-Reviewed Original ResearchConceptsPolypyrimidine tract-binding protein 1Expression of polypyrimidine tract-binding protein 1Stem cell transplantationReprogramming of astrocytesCentral nervous system disordersAlzheimer's diseaseNeurodegenerative disordersNervous system disordersCell transplantationReprogram astrocytesTherapeutic strategiesAnimal modelsSystem disordersDisease outcomeRegenerative therapeuticsNeuronal populationsGlial cellsTherapeutic potentialProtein 1NeuronsAstrocyte heterogeneityDiseaseAstrocytesDisordersPublished studiesThe effects of a psychoeducational intervention on caregivers of colorectal cancer patients: A meta-analysis of randomized controlled trials
Zhang M, Xue Y, Shao M, Yang Y, Yu L, Ma B, Li D, Zhou H, Wang K, Chen C, Cheng M, Wang T. The effects of a psychoeducational intervention on caregivers of colorectal cancer patients: A meta-analysis of randomized controlled trials. European Journal Of Oncology Nursing 2024, 74: 102739. PMID: 39729814, DOI: 10.1016/j.ejon.2024.102739.Peer-Reviewed Original ResearchConceptsPsychoeducational interventionRandomized controlled trialsPsychological statusImpact of psychoeducational interventionsAspects of caregivingReduce caregiver burdenControlled trialsEnhancing caregivers' abilityCondition of caregiversImprove quality of lifeQuality of lifeCaregiver burdenCRC patientsRandom-effects modelCaregivers' abilityCINAHL CompletePerception of family supportGeneral well-beingActive lifestyleWeb of ScienceMeta-analysis of randomized controlled trialsPhysical healthCare scheduleSocial supportFixed-effects modelAntisense oligonucleotides and their applications in rare neurological diseases
McDowall S, Aung-Htut M, Wilton S, Li D. Antisense oligonucleotides and their applications in rare neurological diseases. Frontiers In Neuroscience 2024, 18: 1414658. PMID: 39376536, PMCID: PMC11456401, DOI: 10.3389/fnins.2024.1414658.Peer-Reviewed Original ResearchAntisense oligonucleotidesRare diseaseImpaired quality of lifeDuchenne muscular dystrophyRare neurological diseasesNeurological diseasesClinical trial designSpinal muscular atrophyRare conditionApplication of antisense oligonucleotidesHigh treatment costsTherapeutic antisense oligonucleotidesClinical trialsAnimal modelsMuscular dystrophyEffective treatmentQuality of lifeImpaired qualityMuscular atrophyAntisense oligomersTrial designTherapeutic validityTarget gene expressionDiseaseTreatment costsFinancial toxicity of informal caregivers of colorectal cancer patients: A cross-sectional study
Zhang M, Wang X, Shao M, Li T, Guo S, Yang Y, Yu L, Bin M, Li D, Zhou H, Yao L, Chen C, Wang T. Financial toxicity of informal caregivers of colorectal cancer patients: A cross-sectional study. European Journal Of Oncology Nursing 2024, 69: 102519. PMID: 38402718, DOI: 10.1016/j.ejon.2024.102519.Peer-Reviewed Original ResearchConceptsLevels of financial toxicityFinancial toxicity scoresFinancial toxicitySocial supportPerceived stressColorectal cancer patientsQuality of colorectal cancer careEffects of financial toxicityCancer patientsColorectal cancer careHigh social supportCross-sectional studyInformal caregiversCaregiver ageMultivariate linear regressionCancer careAverage household incomeCaregiversTargeted interventionsMedical insuranceHousehold incomeMultivariate regression analysisMedical costsSurvey designIncreased communication
2023
Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations
Cale J, Ham K, Li D, McIntosh C, Watts G, Wilton S, Aung-Htut M. Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations. Scientific Reports 2023, 13: 19725. PMID: 37957262, PMCID: PMC10643364, DOI: 10.1038/s41598-023-47005-y.Peer-Reviewed Original ResearchConceptsProtein isoformsAntisense oligomersModulate RNA processingLDL receptorInduce alternative splicingLevels of LDL receptorPhysiologically relevant concentrationsHuh-7 cellsLow-density lipoprotein (LDL) receptorProtein domainsRNA processingAlternative splicingExon 2Exon 8Target exonsHinge regionExonHuh-7LDL receptor activityIsoformsPhysiologically relevant levelsLDL uptakeSplicingIsoform expressionProtein overexpressionMitochondria-targeted cyclometalated iridium-β-carboline complexes as potent non-small cell lung cancer therapeutic agents
Chen J, Guo X, Li D, Tang H, Gao J, Yu W, Zhu X, Sun Z, Huang Z, Chen L. Mitochondria-targeted cyclometalated iridium-β-carboline complexes as potent non-small cell lung cancer therapeutic agents. Metallomics 2023, 15: mfad035. PMID: 37204038, DOI: 10.1093/mtomcs/mfad035.Peer-Reviewed Original ResearchConceptsLoss of mitochondrial membrane potentialIridium complexesDeath of A549 cellsMitochondrial membrane potentialA549 cellsDepletion of cellular ATPElevation of reactive oxygen speciesNSCLC therapeutic agentsMitochondrial eventsCaspase pathwayCancer therapeutic agentsReactive oxygen speciesPotential antitumor effectsCellular ATPDevelopment of antitumor drugsMulticellular tumor spheroid modelAntitumor effectNon-smallTumor spheroid modelTumor growthMembrane potentialIridiumOxygen speciesTherapeutic agentsAntitumor drugs
2022
β-cyclodextrin based nano gene delivery using pharmaceutical applications to treat Wolfram syndrome
Quintas P, Al-Salami H, Pfaff A, Li D, Koks S. β-cyclodextrin based nano gene delivery using pharmaceutical applications to treat Wolfram syndrome. Therapeutic Delivery 2022, 13: 449-462. PMID: 36748654, DOI: 10.4155/tde-2022-0036.Peer-Reviewed Original ResearchConceptsWolfram syndromeGene deliveryGene therapy approachesNon-viral vectorsAutosomal recessive neurodegenerative disorderCentral nervous systemRecessive neurodegenerative disorderViral vectorsNonviral vectorsTreatment strategiesTherapeutic benefitTherapy approachesNervous systemSyndromeTherapeutic researchDeliveryTreatmentGenesNeurodegenerative disordersTargeted Molecular Therapeutics for Parkinson's Disease: A Role for Antisense Oligonucleotides?
Li D, Mastaglia F, Yau W, Chen S, Wilton S, Akkari P. Targeted Molecular Therapeutics for Parkinson's Disease: A Role for Antisense Oligonucleotides? Movement Disorders 2022, 37: 2184-2190. PMID: 36036206, PMCID: PMC9804368, DOI: 10.1002/mds.29201.Peer-Reviewed Original Research
2021
Correction to: Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies
Li D, McIntosh C, Mastaglia F, Wilton S, Aung-Htut M. Correction to: Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies. Translational Neurodegeneration 2021, 10: 41. PMID: 34696812, PMCID: PMC8543951, DOI: 10.1186/s40035-021-00267-w.Peer-Reviewed Original Research
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