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Mark Mamula, PhD

Professor of Medicine (Rheumatology)
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About

Titles

Professor of Medicine (Rheumatology)

Biography

Dr. Mamula’s received degrees from UCLA, the University of Notre Dame and the University of Oklahoma. Dr. Mamula’s central research interests are in investigating the early events involved with breaking immune tolerance to self proteins, both in autoimmune disease and in tumor biology. Overall, it is the goal of Dr. Mamula's laboratory to understand the mechanisms that may shift this balance toward the initiation of anti-self immune responses. Seminal work from the Mamula lab elucidated the biochemical forms of autoantigens capable of breaking immunologic tolerance to intracellular autoantigens in systemic lupus erythematosus (SLE), and type 1 diabetes (T1D). Simply put, Dr. Mamula examines posttranslational protein modifications that alter cellular biology and immunity. These studies have now been applied to the development of novel therapeutic approaches in developing anti-tumor vaccines in breast cancer and colon cancer. In addition, studies from the Mamula laboratory first demonstrated the ability of B cells to present autoantigens in the triggering of T cell autoimmunity and in the phenomenon of epitope spreading in lupus autoimmunity. This work preceded more recent studies illustrating the how B cells transfer autoantigens to other antigen presenting cells, including dendritic cells and macrophages.

Appointments

Education & Training

PhD
University of Oklahoma (1986)
MS
University of Notre Dame (1982)
BA
University of California at Los Angeles (1979)

Research

Overview

Dr. Mamula is studying how, in lupus, the body targets itself for attack by its own immune system. Identifying the mechanisms that initiate this process can then help in devising an intervention that will stop this self-destructive cascade.

Medical Subject Headings (MeSH)

Autoantigens; Autoimmune Diseases; Autoimmunity; Immune System; Rheumatology; T-Lymphocytes

Research at a Glance

Yale Co-Authors

Frequent collaborators of Mark Mamula's published research.

Publications

2023

2022

2021

2019

2018

2017

2016

2014

Clinical Trials

Current Trials

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