Philip Corlett, PhD
Associate Professor of PsychiatryCards
About
Research
Publications
2024
Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis
Erickson M, Bansal S, Li C, Waltz J, Corlett P, Gold J. Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis. Biological Psychiatry Global Open Science 2024, 5: 100394. PMID: 39526022, PMCID: PMC11550737, DOI: 10.1016/j.bpsgos.2024.100394.Peer-Reviewed Original ResearchHealthy comparison subjectsReduced mismatch negativityPrediction error signalsPositive symptomsMismatch negativityDeviant typesPredictive coding accountPresence of hallucinationsMismatch negativity paradigmAuditory memory tracesComparison subjectsCoding accountMemory tracesPsychiatric illnessMMN responseVoice hearersRepetitive positioningError signalDuration conditionsHallucinationsHigher-levelDMMNDifferent patternsSymptomsPSZAn Integrated theory of false insights and beliefs under psychedelics
McGovern H, Grimmer H, Doss M, Hutchinson B, Timmermann C, Lyon A, Corlett P, Laukkonen R. An Integrated theory of false insights and beliefs under psychedelics. Communications Psychology 2024, 2: 69. PMID: 39242747, PMCID: PMC11332244, DOI: 10.1038/s44271-024-00120-6.Peer-Reviewed Original ResearchLesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerceptionUnderstanding Cognitive Behavioral Therapy for Psychosis Through the Predictive Coding Framework
Sheffield J, Brinen A, Feola B, Heckers S, Corlett P. Understanding Cognitive Behavioral Therapy for Psychosis Through the Predictive Coding Framework. Biological Psychiatry Global Open Science 2024, 4: 100333. PMID: 38952435, PMCID: PMC11215207, DOI: 10.1016/j.bpsgos.2024.100333.Peer-Reviewed Original ResearchCognitive behavioral therapyPersecutory delusionsBehavioral therapyMaintenance of delusionsSymptoms of psychosisAssociative learning modelsCognitive-behavioral interventionsPrediction error signalsLevels of information processingPredictive coding frameworkHierarchical predictive codingPredictive codingPsychotic disordersPsychological treatmentCognitive neurosciencePsychological processesCBTpPsychosisDelusionsBelief updatingInformation processingAlternative beliefsNeuroscienceProcess theoryComputational neuroscienceBelief Updating, Childhood Maltreatment, and Paranoia in Schizophrenia-Spectrum Disorders
Sloan A, Kittleson A, Torregrossa L, Feola B, Rossi-Goldthorpe R, Corlett P, Sheffield J. Belief Updating, Childhood Maltreatment, and Paranoia in Schizophrenia-Spectrum Disorders. Schizophrenia Bulletin 2024, sbae057. PMID: 38701234, DOI: 10.1093/schbul/sbae057.Peer-Reviewed Original ResearchSchizophrenia spectrum disordersExposure to childhood maltreatmentPositive and Negative Syndrome ScaleChildhood Trauma QuestionnaireChildhood maltreatmentHierarchical Gaussian FilterBelief updatingProbabilistic reversal learningNegative Syndrome ScaleSyndrome ScaleNonpsychiatric controlsReversal learningSchizophrenia spectrumCumulative maltreatmentTrauma QuestionnaireDeprivation exposureGreen et al.ParanoiaConferring riskMaltreatmentPrior expectationsDisordersIndirect effectsChildhoodBeliefsLongitudinal Associations Between Belief Updating and Delusions in Individuals Recovering From an Acute Psychotic Episode
Sheffield J, Hall L, Vandekar S, Liu J, Woodward N, Heckers S, Corlett P. Longitudinal Associations Between Belief Updating and Delusions in Individuals Recovering From an Acute Psychotic Episode. Biological Psychiatry 2024, 95: s66-s67. DOI: 10.1016/j.biopsych.2024.02.164.Peer-Reviewed Original Research11. Role of Prediction Errors in the Relationship Between Ethnoracial Discrimination and Delusions
Huque Z, O'Brien K, Rossi-Goldthorpe R, Kenney J, Mittal V, Strauss G, Walker E, Schiffman J, Woods S, Powers A, Silverstein S, Waltz J, Gold J, Corlett P, Ellman L. 11. Role of Prediction Errors in the Relationship Between Ethnoracial Discrimination and Delusions. Biological Psychiatry 2024, 95: s78-s79. DOI: 10.1016/j.biopsych.2024.02.189.Peer-Reviewed Original ResearchDifferent learning aberrations relate to delusion-like beliefs with different contents
Rossi-Goldthorpe R, Silverstein S, Gold J, Schiffman J, Waltz J, Williams T, Powers A, Woods S, Zinbarg R, Mittal V, Ellman L, Strauss G, Walker E, Levin J, Castiello S, Kenney J, Corlett P. Different learning aberrations relate to delusion-like beliefs with different contents. Brain 2024, 147: 2854-2866. PMID: 38637303, PMCID: PMC11292907, DOI: 10.1093/brain/awae122.Peer-Reviewed Original ResearchProbabilistic reversal learningDelusion-like beliefsProbabilistic reversal learning taskBlocked cueControl cuesBelief convictionBlock taskClinical high-risk statusKamin blocking taskSymptom-specific effectsPrediction error accountLevels of paranoiaIntact learningAberrant learningKamin blockingParanoid individualsPersecutory delusionsCue presentationReversal learningPredicting psychosisCognitive tasksBehavioral resultsDecreased learningDelusionsParanoiaImagination, Agency, and Predictive Processing
Corlett P. Imagination, Agency, and Predictive Processing. 2024, 60-78. DOI: 10.1093/oso/9780198872221.003.0004.Peer-Reviewed Original ResearchPredictive processing theoryTheories of delusionsPredictive coding theorySensory inputDelusion formationSource monitoringProcess theoryDelusionsMediated learningHallucinationsConscious experienceImaginative processesReality perceptionPrediction processNeurocomputer architectureBeliefsPerceptionDysfunctionIllusory generalizability of clinical prediction models
Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Song-making In a Group (SING)
HIC ID2000026376RolePrincipal InvestigatorPrimary Completion Date08/31/2024Recruiting ParticipantsTeen Brain and Behavior Study
HIC ID1111009332RoleSub InvestigatorPrimary Completion Date12/21/2022Recruiting ParticipantsGenderBothAge13 years - 17 years
Academic Achievements & Community Involvement
News
News
- December 17, 2024Source: YaleNews
Paranoia May Be, In Part, a Visual Problem
- November 15, 2024
Corlett Speaks at 'Artificial Intelligence and Mental Health' Conference in Shanghai
- August 12, 2024Source: Yale News
Insights & Outcomes: Sea scorpions, delusions, and forensics-related stress
- June 14, 2024Source: YaleNews
New Insights Into the Brain Regions Involved in Paranoia