AMPA Receptor Components of the Anti-Depressant Ketamine Response

Looking for adults experiencing depression to participate in paid MRI research

Are you currently experiencing severe depression? Have you tried antidepressants before without success? Would you like to participate in a research study? Help us understand the effects of the rapid antidepressant ketamine on the brain and earn up to

$720 compensation for your time.

Study involves:

• A physical examination
• Providing blood for genetic analysis
• Thinking tasks
• Receiving ketamine as an experimental treatment for your depression
• Taking a study drug that may change the effects of the ketamine or your depressive symptoms
• Up to 4 MRI scans
• Speaking on the phone with study staff about how you are feeling after receiving ketamine

Participants must be:

• 18-60 years of age
• Right-handed
• Currently experiencing severe depression
• Have tried at least one antidepressant treatment in the past
• Willing to abstain from using recreational drugs and alcohol for 1 week before each MRI scan

Participants must NOT:

• Have metal in their body that prevents them from getting an MRI scan
• Be currently abusing drugs or alcohol

If you have not received ketamine as a treatment for depression, we will ask you to try ketamine in an outpatient hospital setting for additional compensation.

For more information and to find out if you are eligible, please contact Leslie Maldonado at nempro.lab@yale.edu or call (203) 508-7787.