Xiangyun Yin
Associate Research ScientistDownloadHi-Res Photo
Cards
Appointments
Ophthalmology
Primary
Contact Info
About
Titles
Associate Research Scientist
Appointments
Ophthalmology
Associate Research ScientistPrimary
Other Departments & Organizations
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xiangyun Yin's published research.
Publications Timeline
A big-picture view of Xiangyun Yin's research output by year.
Elise Liu, MD, PhD
Stephanie Eisenbarth, MD, PhD
Laura Rose Hoyt
Shuting Chen
Michael Caplan, PhD, MD
Sam Olyha
10Publications
316Citations
Publications
2024
Scaleable production of highly loaded protein nanoparticles for immune modulation
Caplan M, Baldwin R, Yin X, Grishin A, Eisenbarth S, Sampson H, Bottomly K, Prud’homme R. Scaleable production of highly loaded protein nanoparticles for immune modulation. Communications Materials 2024, 5: 191. DOI: 10.1038/s43246-024-00626-w.Peer-Reviewed Original ResearchConceptsAdjuvants to antigen-presenting cellsImmune modulationAntigen-presenting cellsMurine immune systemImmune system cellsPeanut-allergic patientsDesensitizer applicationPLG nanoparticlesAntigen deliverySystemic exposurePoly(lactide-co-glycolideBasophil activationClinical investigationAllergic responsesImmune systemSystem cellsProtein antigensClinical applicationDelivery of proteinsE. coli phospholipidsSafety evidenceAntigenProtein nanoparticlesDeliveryCellsDendritic cells in food allergy, treatment, and tolerance
Liu E, Yin X, Siniscalco E, Eisenbarth S. Dendritic cells in food allergy, treatment, and tolerance. Journal Of Allergy And Clinical Immunology 2024, 154: 511-522. PMID: 38971539, PMCID: PMC11414995, DOI: 10.1016/j.jaci.2024.06.017.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAntigen presenting cellsDendritic cellsFood allergyOral tolerancePresenting cellsAllergic sensitizationPeripheral T regulatory cellsDevelopment of oral toleranceGut dendritic cellsT regulatory cellsDendritic cell subsetsLimited treatment optionsAdaptive immune responsesFood immunotherapyEpicutaneous immunotherapyCell subsetsTolerogenic programAlarmin releaseTreatment optionsLangerhans cellsFood toleranceInnocuous antigensSurface markersInflammatory conditionsImmune response
2023
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8
Zhang B, Chen S, Yin X, McBride C, Gertie J, Yurieva M, Bielecka A, Hoffmann B, Hinson J, Grassmann J, Xu L, Siniscalco E, Soldatenko A, Hoyt L, Joseph J, Norton E, Uthaman G, Palm N, Liu E, Eisenbarth S, Williams A. Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8. Mucosal Immunology 2023, 17: 431-449. PMID: 38159726, DOI: 10.1016/j.mucimm.2023.12.001.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPlasma cellsLamina propriaT cell-dependent antigensCytokinesis 8 (DOCK8) mutationsDOCK8-deficient miceMucosal IgA productionRecurrent gastrointestinal infectionGut lamina propriaPoor antibody responseIgA class switchingAntigen-specific IgAEarly B cell activationLong-term survivalB cell activationGut IgAFood antigensAntibody responseIgA productionImmune homeostasisGastrointestinal infectionsPrimary immunodeficiencyT cellsPC compartmentB cellsCell activationEscape from the pore.
Yin X, Eisenbarth S. Escape from the pore. Science Immunology 2023, 8: eadj9549. PMID: 37540736, DOI: 10.1126/sciimmunol.adj9549.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
2021
Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations
Gertie JA, Zhang B, Liu EG, Hoyt LR, Yin X, Xu L, Long LL, Soldatenko A, Gowthaman U, Williams A, Eisenbarth SC. Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations. Journal Of Allergy And Clinical Immunology 2021, 149: 262-274. PMID: 34051223, PMCID: PMC8626534, DOI: 10.1016/j.jaci.2021.05.015.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdministration, OralAnimalsArachisDisease Models, AnimalFemaleGastrointestinal MicrobiomeGenetic Predisposition to DiseaseGuanine Nucleotide Exchange FactorsIntestinal MucosaMaleMice, Inbred C3HMice, Inbred C57BLMutationPassive Cutaneous AnaphylaxisPeanut HypersensitivityPermeabilitySpecies SpecificityToll-Like Receptor 4ConceptsC3H/HeJ miceGut permeabilityHeJ miceOral anaphylaxisPeanut challengeFood allergyMouse modelToll-like receptor 4BALB/c miceCytokinesis 8 (DOCK8) mutationsEnhanced gut permeabilityOral peanut challengesDOCK8 functionIngested allergenImmunologic mechanismsAnaphylaxis responsesImmunologic pathwaysAllergic diseasesC57BL/6 micePeanut allergyAntibody responseC miceReceptor 4DOCK8 mutationsIntraperitoneal challengeDendritic Cell Regulation of T Helper Cells
Yin X, Chen S, Eisenbarth SC. Dendritic Cell Regulation of T Helper Cells. Annual Review Of Immunology 2021, 39: 1-32. PMID: 33710920, DOI: 10.1146/annurev-immunol-101819-025146.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDendritic cellsProfessional antigen-presenting cellsDendritic Cell RegulationDifferent DC subsetsT helper cellsAntigen-presenting cellsAdaptive immune responsesT lymphocyte differentiationTh cell differentiationDC subsetsRegulatory cellsDistinct CD4Follicular helperImmune toleranceSubset phenotypesImmune activationHelper cellsImmune cellsImmune responseImmune systemHeterogeneous subsetLymphocyte differentiationLocal tissue microenvironmentTissue microenvironmentCellsAntigen-Presenting Cells in Food Tolerance and Allergy
Liu EG, Yin X, Swaminathan A, Eisenbarth SC. Antigen-Presenting Cells in Food Tolerance and Allergy. Frontiers In Immunology 2021, 11: 616020. PMID: 33488627, PMCID: PMC7821622, DOI: 10.3389/fimmu.2020.616020.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAntigen-presenting cellsDendritic cellsOral toleranceFood allergyT cellsDifferent antigen-presenting cellsB cell antibody responseLife-threatening anaphylaxisT cell responsesImmunoglobulin E antibodiesVariety of symptomsAPC subsetsFood antigensFood toleranceAntibody responseE antibodiesAntigen presentationImmune responseMouse modelFood allergensAllergyInitial primingCell responsesPatient samplesAntigen
2020
Torn between type 1 and type 2 immunity.
Yin X, Eisenbarth SC. Torn between type 1 and type 2 immunity. Science Immunology 2020, 5 PMID: 33158976, DOI: 10.1126/sciimmunol.abf4905.Peer-Reviewed Original ResearchCitationsAltmetricEditors' Choice
Yin X, Eisenbarth S, Pham M, O’Connor K. Editors' Choice. Science Immunology 2020, 5: 852. DOI: 10.1126/science.2020.5.53.twil.Peer-Reviewed Original Research
2019
IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection
Liu D, Yin X, Olyha SJ, Nascimento MSL, Chen P, White T, Gowthaman U, Zhang T, Gertie JA, Zhang B, Xu L, Yurieva M, Devine L, Williams A, Eisenbarth SC. IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection. Immunity 2019, 51: 64-76.e7. PMID: 31231033, PMCID: PMC6685086, DOI: 10.1016/j.immuni.2019.05.011.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsListeria monocytogenes infectionB cellsMonocytogenes infectionInducible nitric oxide synthase (iNOS) expressionNitric oxide synthase expressionExchange factor DOCK8Conventional dendritic cellsOxide synthase expressionMarginal zone B cellsMarginal zoneMZ B cellsIntracellular ListeriaPrime CD8Dendritic cellsIL-10Cell primingInterleukin-10Listeria infectionSynthase expressionWhite pulpCell activationMetallophilic macrophagesBacterial infectionsCD8Infection