Richard Goodman
Associate Research Scientist in NeuroscienceCards
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Associate Research Scientist in Neuroscience
Biography
Goodman received a B.S. degree in Chemistry from MIT in 1970 and was in the first MSTP class, at Penn, where, in 1976, he received MD and PhD degrees. He trained in internal medicine at Tufts-New England Medical Center (NEMC) and endocrinology at NEMC and the Massachusetts General Hospital, working in the laboratory of Joel Habener. Among his accomplishments during this time, Goodman, with Kay Lund, identified GLP-1, the basis of the weight-loss drug Ozempic. He was appointed as an Assistant Professor of Medicine at Harvard in 1982 then returned to NEMC to become the founding director of the Molecular Medicine division, an interdisciplinary program from which four of the six faculty members went on to be elected into the National Academy of Sciences (NAS). Goodman became the Vollum director in 1989, a position he held for 27 years. Throughout his tenure as director, Vollum faculty received many accolades at the national and international level. Goodman was elected into the NAS in 2002 and the National Institute of Medicine in 2005; he received the Distinguished Graduate award from Penn in 2013.
Appointments
Neuroscience
Associate Research ScientistPrimary
Other Departments & Organizations
Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Kevin Sevarino, MD
Publications
2022
Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate.
Koberstein JN, Stewart ML, Smith CB, Tarasov AI, Ashcroft FM, Stork PJS, Goodman RH. Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate. Proc Natl Acad Sci U S A 2022, 119: e2204407119. PMID: 35881794, DOI: 10.1073/pnas.2204407119.Peer-Reviewed Original Research
2016
Biosensor reveals multiple sources for mitochondrial NAD⁺.
Cambronne XA, Stewart ML, Kim D, Jones-Brunette AM, Morgan RK, Farrens DL, Cohen MS, Goodman RH. Biosensor reveals multiple sources for mitochondrial NAD⁺. Science (New York, N.Y.) 2016, 352: 1474-7. PMID: 27313049, PMCID: PMC6530784, DOI: 10.1126/science.aad5168.Peer-Reviewed Original Research
2004
Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions.
Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS, Boss JM, McWeeney S, Dunn JJ, Mandel G, Goodman RH. Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell 2004, 119: 1041-54. PMID: 15620361, DOI: 10.1016/j.cell.2004.10.032.Peer-Reviewed Original Research
2002
Regulation of corepressor function by nuclear NADH.
Zhang Q, Piston DW, Goodman RH. Regulation of corepressor function by nuclear NADH. Science 2002, 295: 1895-7. PMID: 11847309, DOI: 10.1126/science.1069300.Peer-Reviewed Original Research
1995
Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP.
Lundblad JR, Kwok RP, Laurance ME, Harter ML, Goodman RH. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature 1995, 374: 85-8. PMID: 7870179, DOI: 10.1038/374085a0.Peer-Reviewed Original Research
1994
Nuclear protein CBP is a coactivator for the transcription factor CREB.
Kwok RP, Lundblad JR, Chrivia JC, Richards JP, Bächinger HP, Brennan RG, Roberts SG, Green MR, Goodman RH. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 1994, 370: 223-6. PMID: 7913207, DOI: 10.1038/370223a0.Peer-Reviewed Original Research
1993
Phosphorylated CREB binds specifically to the nuclear protein CBP.
Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 1993, 365: 855-9. PMID: 8413673, DOI: 10.1038/365855a0.Peer-Reviewed Original Research
1986
Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.
Montminy M, Sevarino K, Wagner J, Mandel G, Goodman R. Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 6682-6686. PMID: 2875459, PMCID: PMC386573, DOI: 10.1073/pnas.83.18.6682.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRat somatostatin geneSomatostatin geneCAMP responsivenessReporter gene encoding chloramphenicolTranscriptional initiation siteProtein kinase 2Promoter deletion mutantsSimian virus 40 promoterSomatostatin gene promoterCAMP-responsive elementPC12 rat pheochromocytoma cellsKinase 2 activityGene encoding chloramphenicolTranscriptional regulationDeletion mutantsChimeric genePromoter elementsGene promoterGene expressionKinase 2Rat pheochromocytoma cellsInitiation siteResponsive elementGenesBase pairs