Richard Goodman
Associate Research Scientist in NeuroscienceCards
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Associate Research Scientist in Neuroscience
Biography
Goodman received a B.S. degree in Chemistry from MIT in 1970 and was in the first MSTP class, at Penn, where, in 1976, he received MD and PhD degrees. He trained in internal medicine at Tufts-New England Medical Center (NEMC) and endocrinology at NEMC and the Massachusetts General Hospital, working in the laboratory of Joel Habener. Among his accomplishments during this time, Goodman, with Kay Lund, identified GLP-1, the basis of the weight-loss drug Ozempic. He was appointed as an Assistant Professor of Medicine at Harvard in 1982 then returned to NEMC to become the founding director of the Molecular Medicine division, an interdisciplinary program from which four of the six faculty members went on to be elected into the National Academy of Sciences (NAS). Goodman became the Vollum director in 1989, a position he held for 27 years. Throughout his tenure as director, Vollum faculty received many accolades at the national and international level. Goodman was elected into the NAS in 2002 and the National Institute of Medicine in 2005; he received the Distinguished Graduate award from Penn in 2013.
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Neuroscience
Associate Research ScientistPrimary
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Yale Co-Authors
Publications Timeline
Kevin Sevarino, MD
Daniel Alfonso Colón-Ramos, PhD
Frederick Sigworth, PhD
Marc Hammarlund, PhD
Publications
2024
Local and dynamic regulation of neuronal glycolysis in vivo
Wolfe A, Koberstein J, Smith C, Stewart M, Gonzalez I, Hammarlund M, Hyman A, Stork P, Goodman R, Colón-Ramos D. Local and dynamic regulation of neuronal glycolysis in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2314699121. PMID: 38198527, PMCID: PMC10801914, DOI: 10.1073/pnas.2314699121.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGlycolytic stateEnergy stressEnergy metabolismConditions of energy stressDynamic regulationNeuronal functionIndividual cell typesMitochondrial localizationGenetic analysisSubcellular regionsRegulatory enzymeCell-autonomousNeuronal identityGlycolysisCell typesMetabolic stateImaging dynamic changesMetabolismLiving organismsIn vivoCellsEnergy landscapeIndividual neuronsEnzymeDynamic changes
2022
Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate
. Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2204407119. PMID: 35881794, PMCID: PMC9351453, DOI: 10.1073/pnas.2204407119.Peer-Reviewed Original ResearchCitationsAltmetric
2019
Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L
Chatzi C, Zhang Y, Hendricks W, Chen Y, Schnell E, Goodman R, Westbrook G. Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L. ELife 2019, 8: e45920. PMID: 31232686, PMCID: PMC6609409, DOI: 10.7554/elife.45920.Peer-Reviewed Original ResearchCitationsAltmetric
2018
Flow Cytometry Analysis of Free Intracellular NAD+ Using a Targeted Biosensor
Eller J, Stewart M, Slepian A, Markwardt S, Wiedrick J, Cohen M, Goodman R, Cambronne X. Flow Cytometry Analysis of Free Intracellular NAD+ Using a Targeted Biosensor. Current Protocols In Cytometry 2018, 88: e54. PMID: 30556645, PMCID: PMC6422705, DOI: 10.1002/cpcy.54.Peer-Reviewed Original ResearchCitationsAltmetricPharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration
Liu H, Smith C, Schmidt M, Cambronne X, Cohen M, Migaud M, Brenner C, Goodman R. Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 10654-10659. PMID: 30257945, PMCID: PMC6196523, DOI: 10.1073/pnas.1809392115.Peer-Reviewed Original ResearchCitationsAltmetricMethods for Using a Genetically Encoded Fluorescent Biosensor to Monitor Nuclear NAD+
Cohen M, Stewart M, Goodman R, Cambronne X. Methods for Using a Genetically Encoded Fluorescent Biosensor to Monitor Nuclear NAD+. Methods In Molecular Biology 2018, 1813: 391-414. PMID: 30097882, PMCID: PMC6378224, DOI: 10.1007/978-1-4939-8588-3_26.Peer-Reviewed Original ResearchCitations
2017
miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock
Mendoza-Viveros L, Chiang C, Ong J, Hegazi S, Cheng A, Bouchard-Cannon P, Fana M, Lowden C, Zhang P, Bothorel B, Michniewicz M, Magill S, Holmes M, Goodman R, Simonneaux V, Figeys D, Cheng H. miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock. Cell Reports 2017, 19: 505-520. PMID: 28423315, PMCID: PMC5864111, DOI: 10.1016/j.celrep.2017.03.057.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAdaptation, PhysiologicalAnimalsBehavior, AnimalBrain-Derived Neurotrophic FactorCircadian ClocksDendritesDendritic SpinesFemaleGene DeletionGene Expression RegulationLightMaleMesocricetusMethyl-CpG-Binding Protein 2Mice, Inbred C57BLMice, KnockoutMicroRNAsNeuronsPhotoperiodProteomeSeasonsSignal TransductionSuprachiasmatic NucleusTime FactorsTOR Serine-Threonine Kinases
2016
Biosensor reveals multiple sources for mitochondrial NAD+
Cambronne X, Stewart M, Kim D, Jones-Brunette A, Morgan R, Farrens D, Cohen M, Goodman R. Biosensor reveals multiple sources for mitochondrial NAD+. Science 2016, 352: 1474-1477. PMID: 27313049, PMCID: PMC6530784, DOI: 10.1126/science.aad5168.Peer-Reviewed Original ResearchCitationsAltmetricCell-specific Profiling of Nascent Proteomes Using Orthogonal Enzyme-mediated Puromycin Incorporation
Barrett R, Liu H, Jin H, Goodman R, Cohen M. Cell-specific Profiling of Nascent Proteomes Using Orthogonal Enzyme-mediated Puromycin Incorporation. ACS Chemical Biology 2016, 11: 1532-1536. PMID: 27074634, DOI: 10.1021/acschembio.5b01076.Peer-Reviewed Original ResearchCitationsAltmetricTranscriptional Profiling of Newly Generated Dentate Granule Cells Using TU Tagging Reveals Pattern Shifts in Gene Expression during Circuit Integration1,2
Chatzi C, Zhang Y, Shen R, Westbrook G, Goodman R. Transcriptional Profiling of Newly Generated Dentate Granule Cells Using TU Tagging Reveals Pattern Shifts in Gene Expression during Circuit Integration1,2. ENeuro 2016, 3: eneuro.0024-16.2016. PMID: 27011954, PMCID: PMC4797955, DOI: 10.1523/eneuro.0024-16.2016.Peer-Reviewed Original ResearchCitationsAltmetric
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