Kevin Gobeske, MPH, PhD, MD
Associate Research Scientist in NeuroscienceCards
Appointments
Additional Titles
Research Scientist, Nenad Sestab Lab, Neuroscience
Contact Info
Appointments
Additional Titles
Research Scientist, Nenad Sestab Lab, Neuroscience
Contact Info
Appointments
Additional Titles
Research Scientist, Nenad Sestab Lab, Neuroscience
Contact Info
About
Titles
Associate Research Scientist in Neuroscience
Research Scientist, Nenad Sestab Lab, Neuroscience
Biography
Dr. Gobeske is a critical care neurologist and neuroscientist with expertise in the cellular and physiologic mechanisms underlying multiple types of severe brain injury. Dr. Gobeske completed his undergraduate studies at Yale University, followed by a master’s degree in Epidemiology and Biostatistics at the University of California, Berkeley. He then pursued M.D./Ph.D. training at Northwestern University, where he studied the regulation of neurogenesis (new brain cell production) throughout the lifespan. Dr. Gobeske has completed a residency in Neurology at the University of Washington, followed by a fellowship in Neurocritical Care at the Mayo Clinic. During this time, he has undertaken additional postdoctoral neuroscience training as well as global health projects with the World Health Organization and Doctors Without Borders.
Dr. Gobeske is passionate about caring for patients with multiple types of critical neurologic injuries and also about finding the common pathways by which different injuries progress and how these can be slowed or reversed. He is committed to using laboratory developments to advance options for patients, and to using unique patient experiences to drive new studies in science. Working with Dr. Nenad Sestan, his current goals center upon developing new methods to study neuroprotection and recovery after injury from impaired oxygen delivery. He also remains fascinated with uncovering the potential for cells in the adult brain to regain capabilities that were present earlier during neurodevelopment -- both in response to injury and for improvement of normal functions where these features are beneficial.
Appointments
Neuroscience
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Neurology Critical Care Fellowship
- Mayo Clinic (2018)
- Neurology Residency
- University of Washington (2016)
- Internal Medicine Internship
- University of Washington (2013)
- MD
- Northwestern University (2012)
- PhD
- Northwestern University, Neuroscience (2010)
- MPH
- University of California, Berkeley, Epidemiology and Biostatistics (2001)
- BS
- Yale University, Biology (1999)
Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Guido J. Falcone, MD, ScD, MPH
Lauren Hachmann Sansing, MD, MS, FAHA, FANA
Matthew Yuen
Rachel Beekman, MD
Joseph Schindler, MD
Adam Jasne, MD
Publications
2022
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex
Ma S, Skarica M, Li Q, Xu C, Risgaard RD, Tebbenkamp ATN, Mato-Blanco X, Kovner R, Krsnik Ž, de Martin X, Luria V, Martí-Pérez X, Liang D, Karger A, Schmidt DK, Gomez-Sanchez Z, Qi C, Gobeske KT, Pochareddy S, Debnath A, Hottman CJ, Spurrier J, Teo L, Boghdadi AG, Homman-Ludiye J, Ely JJ, Daadi EW, Mi D, Daadi M, Marín O, Hof PR, Rasin MR, Bourne J, Sherwood CC, Santpere G, Girgenti MJ, Strittmatter SM, Sousa AMM, Sestan N. Molecular and cellular evolution of the primate dorsolateral prefrontal cortex. Science 2022, 377: eabo7257. PMID: 36007006, PMCID: PMC9614553, DOI: 10.1126/science.abo7257.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMolecular differencesSingle-nucleus transcriptomesSubset of speciesNeuropsychiatric risk genesCellular evolutionCellular repertoireEvolutionary specializationDorsolateral prefrontal cortexRate-limiting enzymeDivergent featuresRisk genesAnthropoid primatesPrefrontal cortexPrimate dorsolateral prefrontal cortexCertain interneuronsNeuropeptide somatostatinDopamine productionGranular neuronsTyrosine hydroxylaseCell subtypesExpressionTranscriptomeAdult humansGenesPrimatesCellular recovery after prolonged warm ischaemia of the whole body
Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSingle-nucleus transcriptomic analysesSpecific gene expression patternsCellular recoveryGene expression patternsCellular processesMammalian cellsTranscriptomic analysisLarge mammalsExpression patternsCellular repair processesCell deathComprehensive resourceUnderappreciated potentialPhysiological challengesTissue integrityRepair processSpecific changesPorcine brainMammalsOrgansMultiple organsRetroperitoneal Hematoma as a Complication of Anticoagulation Therapy with Heparin
Beekman R, Powell T, Gobeske K, Jabbour G. Retroperitoneal Hematoma as a Complication of Anticoagulation Therapy with Heparin. Panamerican Journal Of Trauma Critical Care & Emergency Surgery 2022, 11: 51-53. DOI: 10.5005/jp-journals-10030-1372.Peer-Reviewed Original ResearchPortable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke
Yuen MM, Prabhat AM, Mazurek MH, Chavva IR, Crawford A, Cahn BA, Beekman R, Kim JA, Gobeske KT, Petersen NH, Falcone GJ, Gilmore EJ, Hwang DY, Jasne AS, Amin H, Sharma R, Matouk C, Ward A, Schindler J, Sansing L, de Havenon A, Aydin A, Wira C, Sze G, Rosen MS, Kimberly WT, Sheth KN. Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke. Science Advances 2022, 8: eabm3952. PMID: 35442729, PMCID: PMC9020661, DOI: 10.1126/sciadv.abm3952.Peer-Reviewed Original ResearchCitationsAltmetricConceptsIschemic strokeMagnetic resonance imagingResonance imagingFluid-attenuated inversion recoveryDiffusion-weighted imaging sequencesStroke volume measurementsStroke pathwayStroke severityFunctional outcomeLow-field magnetic resonance imagingBedside evaluationClinical managementStroke volumeMRI studiesStrokePatientsBrain imagingCerebellar structuresHigh-field MRI studiesHyperintense regionsInversion recoveryInfarctsUseful imagingVolume measurementsBedside detection of intracranial midline shift using portable magnetic resonance imaging
Sheth KN, Yuen MM, Mazurek MH, Cahn BA, Prabhat AM, Salehi S, Shah JT, By S, Welch EB, Sofka M, Sacolick LI, Kim JA, Payabvash S, Falcone GJ, Gilmore EJ, Hwang DY, Matouk C, Gordon-Kundu B, RN AW, Petersen N, Schindler J, Gobeske KT, Sansing LH, Sze G, Rosen MS, Kimberly WT, Kundu P. Bedside detection of intracranial midline shift using portable magnetic resonance imaging. Scientific Reports 2022, 12: 67. PMID: 34996970, PMCID: PMC8742125, DOI: 10.1038/s41598-021-03892-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMidline shiftNeuroscience intensive care unitCare measurementYale-New Haven HospitalValuable bedside toolIntensive care unitPoor clinical outcomeBrain-injured patientsMass effectNew Haven HospitalMagnetic resonance imagingClinical outcomesIll patientsCare unitStroke patientsFunctional outcomeBedside toolObservational studyBedside detectionImaging examsPatientsResonance imagingPortable MRIImaging suiteSignificant concordance
2020
Portable, Bedside, Low-field Magnetic Resonance Imaging in an Intensive Care Setting for Intracranial Hemorrhage (270)
Shah J, Cahn B, By S, Welch E, Sacolick L, Yuen M, Mazurek M, Wira C, Leasure A, Matouk C, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Sze G, Rosen M, Kimberly W, Sheth K. Portable, Bedside, Low-field Magnetic Resonance Imaging in an Intensive Care Setting for Intracranial Hemorrhage (270). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.270.Peer-Reviewed Original ResearchCitationsDeployment of Portable, Bedside, Low-field Magnetic Resonance Imaging for Evaluation of Stroke Patients (272)
Cahn B, Shah J, Dyvorne H, O’Halloran R, Poole M, Yuen M, Mazurek M, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Wira C, Matouk C, Sze G, Rosen M, Kimberly W, Sheth K. Deployment of Portable, Bedside, Low-field Magnetic Resonance Imaging for Evaluation of Stroke Patients (272). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.272.Peer-Reviewed Original ResearchCitations
2019
Paroxysmal Sympathetic Hyperactivity
Gobeske K. Paroxysmal Sympathetic Hyperactivity. 2019, c18-c18.p27. DOI: 10.1093/med/9780190862923.003.0018.Peer-Reviewed Original ResearchConceptsIntensive care unitNeurocritical careAbnormal laboratory test resultsIll neurologic patientsParoxysmal sympathetic hyperactivityMagnetic resonance imagingSympathetic hyperactivityClinical courseInitial presentationNeurologic examinationNeurologic testsCare unitNeurologic patientsClinical practiceLesion localizationResonance imagingGold standardLaboratory test resultsCarePatientsPrognosisHyperactivityPhysiciansDiagnosisNeurologySerotonin Syndrome
Gobeske K, Wijdicks E. Serotonin Syndrome. 2019, c75-c75.p28. DOI: 10.1093/med/9780190862923.003.0075.Peer-Reviewed Original Research
2018
1191
Fuentes X, Breighner C, Gobeske K, Nelson S, Finley K, Bowron C, Elmer J, Danielson R, Park J. 1191. Critical Care Medicine 2018, 46: 579. DOI: 10.1097/01.ccm.0000529196.49848.97.Peer-Reviewed Original Research