Kevin Gobeske, MPH, PhD, MD
Associate Research Scientist in NeuroscienceCards
About
Research
Publications
2026
Adaptive evolution of gene regulatory networks in mammalian neocortex
Li Z, Kaur N, Santpere G, Muchnik S, Sindhu S, Qi C, Shibata M, Clément O, Klarić T, de Martin X, Luria V, Cho H, Li M, Shibata A, Choi S, Kim H, Tebbenkamp A, Ma S, Han W, Kim S, Pochareddy S, Duy P, Xing X, Bao Y, Xu X, Gladwyn-Ng I, Cullen H, Paolino A, Fenlon L, Kozulin P, Suárez R, Risgaard R, Gulden F, Karger A, Suzuki I, Hirata T, Gobeske K, Richards L, Sousa A, Heng J, Sestan N. Adaptive evolution of gene regulatory networks in mammalian neocortex. Nature 2026, 1-11. PMID: 41851468, DOI: 10.1038/s41586-026-10226-y.Peer-Reviewed Original ResearchCis-regulatory elementsAdaptive evolutionEvolution of gene regulatory networksPutative cis-regulatory elementsGene expressionGene regulatory networksLandscape of gene expressionAssociated with genesTarget gene expressionModern reptilesHighest conservationRegulatory networksBinding motifRegulatory nodesPrefrontal cortexEvolutionary adaptationIntellectual disabilityMolecular diversityBrain connectivityExcitatory projection neuronsZBTB18Complex brainsProjection neuronsMammalsBrainHuman-specific features of the cerebellum and ZP2-regulated synapse development
Kim S, Cherskov A, Sindhwani A, Choi S, Kim H, Li M, Zhang M, Mato-Blanco X, Liu Y, Micali N, Young D, Estacion M, Zhang Y, Ruiz-Jiménez J, Nadkarni A, Luria V, Sindhu S, Chatterjee I, Shibata A, Liang D, Cho H, Park S, Spajic A, Kovner R, Glavan M, Chen R, Risgaard R, Li X, Pochareddy S, Karger A, Huttner A, Morozov Y, Daadi E, Colantuoni C, Gobeske K, Ely J, Hof P, Daadi M, Sherwood C, Duque A, Ma S, Sousa A, Waxman S, Rakic P, Santpere G, Sanders S, Sestan N. Human-specific features of the cerebellum and ZP2-regulated synapse development. Cell 2026, 189: 1802-1819.e28. PMID: 41819103, DOI: 10.1016/j.cell.2026.02.014.Peer-Reviewed Original ResearchConceptsHuman granule cellsZona pellucida glycoprotein 2Granule cellsNeuronal electrophysiological activityAdult cerebellar cortexSynapse regulationCognitive functionGlomerular synapsesNon-human primatesCerebellar cortexMotor coordinationMossy fibersGamete interactionGlycoprotein 2Human brainSynapse developmentSynaptic proteinsElectrophysiological activityHuman cerebellumEvolutionary developmentHuman-specific featuresCo-optionCerebellumHuman adaptationChromatin accessibility profiles
2025
The human and non-human primate developmental GTEx projects
Bell T, Blanchard T, Hernandez R, Linn R, Taylor D, VonDran M, Ahooyi T, Beitra D, Bernieh A, Delaney M, Faith M, Fattahi E, Footer D, Gilbert M, Guambaña S, Gulino S, Hanson J, Hattrell E, Heinemann C, Kreeb J, Leino D, Mcdevitt L, Palmieri A, Pfeiffer M, Pryhuber G, Rossi C, Rasool I, Roberts R, Salehi A, Savannah E, Stachowicz K, Stokes D, Suplee L, Van Hoose P, Wilkins B, Williams-Taylor S, Zhang S, Ardlie K, Getz G, Lappalainen T, Montgomery S, Aguet F, Anderson L, Bernstein B, Choudhary A, Domenech L, Gaskell E, Johnson M, Liu Q, Marderstein A, Nedzel J, Okonda J, Padhi E, Rosano M, Russell A, Walker B, Sestan N, Gerstein M, Milosavljevic A, Borsari B, Cho H, Clarke D, Deveau A, Galeev T, Gobeske K, Hameed I, Huttner A, Jensen M, Jiang Y, Li J, Liu J, Liu Y, Ma J, Mane S, Meng R, Nadkarni A, Ni P, Park S, Petrosyan V, Pochareddy S, Salamon I, Xia Y, Yates C, Zhang M, Zhao H, Conrad D, Feng G, Brady F, Boucher M, Carbone L, Castro J, del Rosario R, Held M, Hennebold J, Lacey A, Lewis A, Lima A, Mahyari E, Moore S, Okhovat M, Roberts V, de Castro S, Wessel B, Zaniewski H, Zhang Q, Arguello A, Baroch J, Dayal J, Felsenfeld A, Ilekis J, Jose S, Lockhart N, Miller D, Minear M, Parisi M, Price A, Ramos E, Zou S. The human and non-human primate developmental GTEx projects. Nature 2025, 637: 557-564. PMID: 39815096, PMCID: PMC12013525, DOI: 10.1038/s41586-024-08244-9.Peer-Reviewed Original ResearchConceptsChromatin accessibility dataFunctional genomic studiesWhole-genome sequencingEffects of genetic variationSpatial gene expression profilesNon-human primatesGenotype-Tissue ExpressionGene expression profilesGenomic studiesGene regulationGenetic dataGenetic variationGenomic researchDonor diversityCommunity engagementHuman evolutionEarly developmental defectsGene expressionCell statesDevelopmental programmeHuman diseasesExpression profilesAdult tissuesDevelopmental defectsSingle-cell
2024
Transcriptome-Connectome association from fetal stage to adulthood
Ouyang M, Poddar T, Santpere G, Andrijevic D, Ma S, Pattabiraman K, Gobeske K, Sestan N, Huang H. Transcriptome-Connectome association from fetal stage to adulthood. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/2389.Peer-Reviewed Original ResearchVirology, ecology, epidemiology, pathology, and treatment of eastern equine encephalitis
Zubair A, McAlpine L, Gobeske K. Virology, ecology, epidemiology, pathology, and treatment of eastern equine encephalitis. Journal Of The Neurological Sciences 2024, 457: 122886. PMID: 38278094, DOI: 10.1016/j.jns.2024.122886.Peer-Reviewed Original Research
2023
Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon
Micali N, Ma S, Li M, Kim S, Mato-Blanco X, Sindhu S, Arellano J, Gao T, Shibata M, Gobeske K, Duque A, Santpere G, Sestan N, Rakic P. Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon. Science 2023, 382: eadf3786. PMID: 37824652, PMCID: PMC10705812, DOI: 10.1126/science.adf3786.Peer-Reviewed Original Research
2022
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex
Ma S, Skarica M, Li Q, Xu C, Risgaard RD, Tebbenkamp ATN, Mato-Blanco X, Kovner R, Krsnik Ž, de Martin X, Luria V, Martí-Pérez X, Liang D, Karger A, Schmidt DK, Gomez-Sanchez Z, Qi C, Gobeske KT, Pochareddy S, Debnath A, Hottman CJ, Spurrier J, Teo L, Boghdadi AG, Homman-Ludiye J, Ely JJ, Daadi EW, Mi D, Daadi M, Marín O, Hof PR, Rasin MR, Bourne J, Sherwood CC, Santpere G, Girgenti MJ, Strittmatter SM, Sousa AMM, Sestan N. Molecular and cellular evolution of the primate dorsolateral prefrontal cortex. Science 2022, 377: eabo7257. PMID: 36007006, PMCID: PMC9614553, DOI: 10.1126/science.abo7257.Peer-Reviewed Original ResearchConceptsMolecular differencesSingle-nucleus transcriptomesSubset of speciesNeuropsychiatric risk genesCellular evolutionCellular repertoireEvolutionary specializationDorsolateral prefrontal cortexRate-limiting enzymeDivergent featuresRisk genesAnthropoid primatesPrefrontal cortexPrimate dorsolateral prefrontal cortexCertain interneuronsNeuropeptide somatostatinDopamine productionGranular neuronsTyrosine hydroxylaseCell subtypesExpressionTranscriptomeAdult humansGenesPrimatesCellular recovery after prolonged warm ischaemia of the whole body
Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.Peer-Reviewed Original ResearchConceptsSingle-nucleus transcriptomic analysesSpecific gene expression patternsCellular recoveryGene expression patternsCellular processesMammalian cellsTranscriptomic analysisLarge mammalsExpression patternsCellular repair processesCell deathComprehensive resourceUnderappreciated potentialPhysiological challengesTissue integrityRepair processSpecific changesPorcine brainMammalsOrgansMultiple organsRetroperitoneal Hematoma as a Complication of Anticoagulation Therapy with Heparin
Jabbour G, Beekman R, Powell T, Gobeske K. Retroperitoneal Hematoma as a Complication of Anticoagulation Therapy with Heparin. Panamerican Journal Of Trauma Critical Care & Emergency Surgery 2022, 11: 51-53. DOI: 10.5005/jp-journals-10030-1372.Peer-Reviewed Original ResearchPortable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke
Yuen MM, Prabhat AM, Mazurek MH, Chavva IR, Crawford A, Cahn BA, Beekman R, Kim JA, Gobeske KT, Petersen NH, Falcone GJ, Gilmore EJ, Hwang DY, Jasne AS, Amin H, Sharma R, Matouk C, Ward A, Schindler J, Sansing L, de Havenon A, Aydin A, Wira C, Sze G, Rosen MS, Kimberly WT, Sheth KN. Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke. Science Advances 2022, 8: eabm3952. PMID: 35442729, PMCID: PMC9020661, DOI: 10.1126/sciadv.abm3952.Peer-Reviewed Original ResearchIschemic strokeMagnetic resonance imagingResonance imagingFluid-attenuated inversion recoveryDiffusion-weighted imaging sequencesStroke volume measurementsStroke pathwayStroke severityFunctional outcomeLow-field magnetic resonance imagingBedside evaluationClinical managementStroke volumeMRI studiesStrokePatientsBrain imagingCerebellar structuresHigh-field MRI studiesHyperintense regionsInversion recoveryInfarctsUseful imagingVolume measurements
Academic Achievements & Community Involvement
Get In Touch
Contacts
Appointment Number