2022
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex
Ma S, Skarica M, Li Q, Xu C, Risgaard RD, Tebbenkamp ATN, Mato-Blanco X, Kovner R, Krsnik Ž, de Martin X, Luria V, Martí-Pérez X, Liang D, Karger A, Schmidt DK, Gomez-Sanchez Z, Qi C, Gobeske KT, Pochareddy S, Debnath A, Hottman CJ, Spurrier J, Teo L, Boghdadi AG, Homman-Ludiye J, Ely JJ, Daadi EW, Mi D, Daadi M, Marín O, Hof PR, Rasin MR, Bourne J, Sherwood CC, Santpere G, Girgenti MJ, Strittmatter SM, Sousa AMM, Sestan N. Molecular and cellular evolution of the primate dorsolateral prefrontal cortex. Science 2022, 377: eabo7257. PMID: 36007006, PMCID: PMC9614553, DOI: 10.1126/science.abo7257.Peer-Reviewed Original ResearchConceptsMolecular differencesSingle-nucleus transcriptomesSubset of speciesNeuropsychiatric risk genesCellular evolutionCellular repertoireEvolutionary specializationDorsolateral prefrontal cortexRate-limiting enzymeDivergent featuresRisk genesAnthropoid primatesPrefrontal cortexPrimate dorsolateral prefrontal cortexCertain interneuronsNeuropeptide somatostatinDopamine productionGranular neuronsTyrosine hydroxylaseCell subtypesExpressionTranscriptomeAdult humansGenesPrimatesCellular recovery after prolonged warm ischaemia of the whole body
Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.Peer-Reviewed Original ResearchConceptsSingle-nucleus transcriptomic analysesSpecific gene expression patternsCellular recoveryGene expression patternsCellular processesMammalian cellsTranscriptomic analysisLarge mammalsExpression patternsCellular repair processesCell deathComprehensive resourceUnderappreciated potentialPhysiological challengesTissue integrityRepair processSpecific changesPorcine brainMammalsOrgansMultiple organsRetroperitoneal Hematoma as a Complication of Anticoagulation Therapy with Heparin
Beekman R, Powell T, Gobeske K, Jabbour G. Retroperitoneal Hematoma as a Complication of Anticoagulation Therapy with Heparin. Panamerican Journal Of Trauma Critical Care & Emergency Surgery 2022, 11: 51-53. DOI: 10.5005/jp-journals-10030-1372.Peer-Reviewed Original ResearchPortable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke
Yuen MM, Prabhat AM, Mazurek MH, Chavva IR, Crawford A, Cahn BA, Beekman R, Kim JA, Gobeske KT, Petersen NH, Falcone GJ, Gilmore EJ, Hwang DY, Jasne AS, Amin H, Sharma R, Matouk C, Ward A, Schindler J, Sansing L, de Havenon A, Aydin A, Wira C, Sze G, Rosen MS, Kimberly WT, Sheth KN. Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke. Science Advances 2022, 8: eabm3952. PMID: 35442729, PMCID: PMC9020661, DOI: 10.1126/sciadv.abm3952.Peer-Reviewed Original ResearchIschemic strokeMagnetic resonance imagingResonance imagingFluid-attenuated inversion recoveryDiffusion-weighted imaging sequencesStroke volume measurementsStroke pathwayStroke severityFunctional outcomeLow-field magnetic resonance imagingBedside evaluationClinical managementStroke volumeMRI studiesStrokePatientsBrain imagingCerebellar structuresHigh-field MRI studiesHyperintense regionsInversion recoveryInfarctsUseful imagingVolume measurementsBedside detection of intracranial midline shift using portable magnetic resonance imaging
Sheth KN, Yuen MM, Mazurek MH, Cahn BA, Prabhat AM, Salehi S, Shah JT, By S, Welch EB, Sofka M, Sacolick LI, Kim JA, Payabvash S, Falcone GJ, Gilmore EJ, Hwang DY, Matouk C, Gordon-Kundu B, RN AW, Petersen N, Schindler J, Gobeske KT, Sansing LH, Sze G, Rosen MS, Kimberly WT, Kundu P. Bedside detection of intracranial midline shift using portable magnetic resonance imaging. Scientific Reports 2022, 12: 67. PMID: 34996970, PMCID: PMC8742125, DOI: 10.1038/s41598-021-03892-7.Peer-Reviewed Original ResearchConceptsMidline shiftNeuroscience intensive care unitCare measurementYale-New Haven HospitalValuable bedside toolIntensive care unitPoor clinical outcomeBrain-injured patientsMass effectNew Haven HospitalMagnetic resonance imagingClinical outcomesIll patientsCare unitStroke patientsFunctional outcomeBedside toolObservational studyBedside detectionImaging examsPatientsResonance imagingPortable MRIImaging suiteSignificant concordance
2020
Portable, Bedside, Low-field Magnetic Resonance Imaging in an Intensive Care Setting for Intracranial Hemorrhage (270)
Shah J, Cahn B, By S, Welch E, Sacolick L, Yuen M, Mazurek M, Wira C, Leasure A, Matouk C, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Sze G, Rosen M, Kimberly W, Sheth K. Portable, Bedside, Low-field Magnetic Resonance Imaging in an Intensive Care Setting for Intracranial Hemorrhage (270). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.270.Peer-Reviewed Original ResearchDeployment of Portable, Bedside, Low-field Magnetic Resonance Imaging for Evaluation of Stroke Patients (272)
Cahn B, Shah J, Dyvorne H, O’Halloran R, Poole M, Yuen M, Mazurek M, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Wira C, Matouk C, Sze G, Rosen M, Kimberly W, Sheth K. Deployment of Portable, Bedside, Low-field Magnetic Resonance Imaging for Evaluation of Stroke Patients (272). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.272.Peer-Reviewed Original Research
2019
Paroxysmal Sympathetic Hyperactivity
Gobeske K. Paroxysmal Sympathetic Hyperactivity. 2019, c18-c18.p27. DOI: 10.1093/med/9780190862923.003.0018.Peer-Reviewed Original ResearchIntensive care unitNeurocritical careAbnormal laboratory test resultsIll neurologic patientsParoxysmal sympathetic hyperactivityMagnetic resonance imagingSympathetic hyperactivityClinical courseInitial presentationNeurologic examinationNeurologic testsCare unitNeurologic patientsClinical practiceLesion localizationResonance imagingGold standardLaboratory test resultsCarePatientsPrognosisHyperactivityPhysiciansDiagnosisNeurologySerotonin Syndrome
Gobeske K, Wijdicks E. Serotonin Syndrome. 2019, c75-c75.p28. DOI: 10.1093/med/9780190862923.003.0075.Peer-Reviewed Original Research
2018
1191
Fuentes X, Breighner C, Gobeske K, Nelson S, Finley K, Bowron C, Elmer J, Danielson R, Park J. 1191. Critical Care Medicine 2018, 46: 579. DOI: 10.1097/01.ccm.0000529196.49848.97.Peer-Reviewed Original Research
2014
CN-10SHOULD CARBOXYPEPTIDASE BE USED MORE OFTEN SINCE ITS FDA APPROVAL? - A CASE OF SUCCESSFUL METHOTREXATE TOXICITY RESCUE IN A PATIENT WITH NEUROLYMPHOMATOSIS
Ly I, Romba M, Gobeske K, Mrugala M. CN-10SHOULD CARBOXYPEPTIDASE BE USED MORE OFTEN SINCE ITS FDA APPROVAL? - A CASE OF SUCCESSFUL METHOTREXATE TOXICITY RESCUE IN A PATIENT WITH NEUROLYMPHOMATOSIS. Neuro-Oncology 2014, 16: v48-v48. PMCID: PMC4218004, DOI: 10.1093/neuonc/nou243.10.Peer-Reviewed Original ResearchMTX toxicityCauda equinaMTX concentrationsT2/FLAIR hyperintensityDiffuse large B-cell lymphomaLarge B-cell lymphomaAcute communicating hydrocephalusCSF flow cytometryAcute kidney injuryHigh-dose methotrexateYear old womanRight abdominal wallB-cell lymphomaHemispheric sulciUrine alkalinizationHematologic toxicityKidney injurySpinal irradiationFDG avidityLeptomeningeal enhancementMTX levelsCommunicating hydrocephalusMature B cellsThoracic cordVentriculoperitoneal shunt
1999
A role for norepinephrine in stress-induced cognitive deficits: α-1-adrenoceptor mediation in the prefrontal cortex
Birnbaum S, Gobeske K, Auerbach J, Taylor J, Arnsten A. A role for norepinephrine in stress-induced cognitive deficits: α-1-adrenoceptor mediation in the prefrontal cortex. Biological Psychiatry 1999, 46: 1266-1274. PMID: 10560032, DOI: 10.1016/s0006-3223(99)00138-9.Peer-Reviewed Original ResearchConceptsStress-induced cognitive deficitsPoor attention regulationAlternation performanceSpatial working memoryPFC cognitive functionPrefrontal cortical dysfunctionMotor response timeIntra-PFC infusionsStress-induced deficitsStress-induced impairmentWorking memoryAttention regulationPFC contributeMemory performanceAlternation testingStress researchNeuropsychiatric disordersPrefrontal cortexCognitive deficitsCognitive functionMemory functionMemory impairmentPFC dysfunctionPerseverative patternsPharmacological stressor