Pathology Research Laboratories

Are you interested in supporting research at Yale Pathology? Please click here for more information. Gifts can be designated for specific laboratories or programs.

Sarah Aitken Laboratory. The Aitken Lab applies experimental and computational approaches to study mechanisms of mutagenesis, the genetic and epigenetic basis of carcinogenesis, and the consequences of genetic diversity on cancer evolution.

Arnaud Augert Laboratory. The goal of the Augert laboratory is to dissect the transcriptional and epigenetic mechanisms that promote cancer development and modulate therapeutic responses. The lab is particularly interested in the study of small cell lung cancer (SCLC), a very aggressive and lethal neuroendocrine tumor.

Demetrios Braddock Laboratory. The Braddock lab studies severe and poorly addressed human diseases to understand disease pathogenesis and unveil therapeutic targets. The lab is particularly interested in rare diseases of children, and in the design and engineering of novel biologics to modulate disease outcome.

Marcello DiStasio Laboratory. The DiStasio lab studies neuroimmunology with a focus on interactions at the borders of the central nervous system. The lab investigates how immune cells at CNS interfaces such as the choroid plexus, meninges, and perivascular spaces shape brain homeostasis and contribute to neurological disease.

Vishwa Deep Dixit Laboratory. The Dixit Lab is focused on understanding the interactions between metabolic and immune systems with the goal of revealing molecular targets that can be harnessed to control inflammation and immune dysfunction as means to enhance the health span.

Karin Finberg Laboratory. In the Finberg Laboratory, we use genetic approaches to investigate mechanisms that regulate systemic iron balance in normal physiology and to understand how disruption of these mechanisms contributes to the pathogenesis of clinical disorders of iron metabolism.

Pallavi Gopal Laboratory. The Gopal Laboratory studies mRNA transport, RNA metabolism and its regulation in healthy and diseased neurons, in order to identify therapeutic targets for neurodegenerative diseases such as Alzheimer’s disease (AD), frontotemporal dementia, and amyotrophic lateral sclerosis (ALS).

Won Jae Huh Laboratory. The Huh Lab focuses on deciphering the molecular drivers of cell plasticity, exploring how these processes facilitate organ regeneration or tip toward early-stage cancer in the stomach and liver.

Shaoning Jiang Laboratory. The Jiang laboratory studies epigenetic mechanisms linking inflammation and energy metabolism in the context of developmental origins of obesity and obesity-related disorders.

Samuel Katz Laboratory. The Katz Laboratory studies mechanisms of cell death through BCL-2 family proteins and engineered immune cell therapies, using multidisciplinary approaches to develop selective therapeutic strategies for cancer and neurodegenerative diseases.

Steven Kleinstein Laboratory. The Kleinstein Laboratory is a computational immunology lab. The lab’s work combines techniques from dynamic modeling, systems biology and bioinformatics to better understand the immune response.

Yuval Kluger Laboratory. The Yuval Kluger Laboratory develops spectral, AI, and statistical methods for the analysis of single-cell and spatial high-dimensional omics data. Working at the interface of applied mathematics and biomedicine, the lab collaborates closely with experimental and translational scientists to apply these tools to cancer, immunology, developmental systems, and neuroscience, to uncover cellular states, tissue organization, and clinically relevant biomarkers.

Themis Kyriakides Laboratory. The Kyriakides Laboratory’s specialized research interests include regenerative medicine applications with a focus on extracellular matrix-based biomaterials. The lab focuses on tissue repair, diabetic wound healing, and cardiovascular interventions and studies processes such as inflammation, angiogenesis, and extracellular matrix remodeling. Using materials from native sources, we develop reparative hydrogels, vascular grafts, and skin substitutes.

Nelson LaMarche Laboratory: The LaMarche Laboratory is a cancer immunology lab in the Department of Pathology and the Yale Cancer Biology Institute. Working closely with physicians and basic scientists, the lab combines high-dimensional profiling of cancer patient tissues with detailed mechanistic studies in mouse models to develop new immunotherapies for solid tumors.

P. Kent Langston Laboratory. The Langston Laboratory studies how the immune system senses exercise and regulates its benefits in youth and during aging. A primary goal of this work is to design exercise-inspired interventions to combat age-associated inflammation to improve healthspan.

Stephania Libreros Laboratory. The Libreros Laboratory aims to elucidate the biochemical, immunological, and molecular mechanisms that orchestrate the resolution of inflammation to restore organ-specific and systemic homeostasis following pathological insults, and to define how disruptions in these regulatory circuits contribute to the development of chronic inflammation.

Chen Liu Laboratory. The focus of the research in the Chen Liu Laboratory is on understanding of virus or alcohol-induced carcinogenesis, cancer biomarker discovery and novel therapies using small molecules and immunotherapy.

Yang Liu Laboratory. The Yang Liu Lab develops and applies spatial omics technologies, including transcriptomics, genomics, epigenomics, and proteomics, to investigate disease biology. We also create tools to study spatial metagenomics and understand how microbial communities are organized within tissue environments.

Caleigh Mandel-Brehm Laboratory. Dr. Mandel-Brehm’s research program uses both translational and basic science approaches to better understand autoimmune disorders of the central nervous system.

Haris Mirza Laboratory. The Mirza Laboratory studies how the immune system senses precancerous cells and prevents tumor initiation in the colon. The overarching goal of this work is to develop immune prevention strategies against colon cancer.

Gilbert Moeckel Laboratory. The research focus of the Moeckel Laboratory is acute tubular injury (ATI) repair and progression of acute kidney injury (AKI) to chronic kidney disease (CKD). The lab is especially interested in how interstitial cells facilitate tubular epithelial cell survival and prevent CKD.

Jon Morrow Laboratory. The Morrow Laboratory focuses our studies on understanding the principles of cell membrane biogenesis and order. Specifically, we investigate the mechanisms of the spectrin-based scaffold in hematological and neurological disease.

Don Nguyen Laboratory. The Nguyen Laboratory does investigation in the following areas: Metastasis; Tissue development; Lung cancer; Cancer genomics; Tumor microenvironment.

Katerina Politi Laboratory. The Politi Laboratory studies mechanisms of lung tumorigenesis and in particular, the molecular features of tumors that determine response and resistance to targeted drugs.

David Rimm Laboratory. The Rimm Laboratory studies the development and use of quantitative approaches to pathology and assay development to classify tumors or predict invasion, metastasis or response to cancer therapy.

Kurt Schalper Laboratory. The Schalper Laboratory focuses on defining novel predictive biomarkers to identify responders and non-responders among patients who are being treated with immunotherapy for lung cancer.

Jeffrey Sklar Laboratory. Research in the Sklar Laboratory generally concerns the molecular biology of human disease, particularly in the areas of the molecular genetics of cancer, lymphocyte biology, endometrial function, and the development of molecular methods for disease diagnosis. The research is of both a basic and translational nature.

David F. Stern Laboratory. The Stern Laboratory investigates dysregulation of growth factor signaling and DNA damage response pathways that lead to cancer, and how to deploy drug combinations targeting these pathways for cancer control.

Joshua Warrick Laboratory. The Warrick lab studies transcriptional networks operative in bladder cancer phenotype and therapy response.

Gur Yaari Laboratory. The Yaari Laboratory is a computational lab focused on immunology. The laboratory develops statistical and probabilistic methods to analyze and model immune diversity and disease

Qin Yan Laboratory. The Yan laboratory studies how epigenetic aberrations cause cancer and other human diseases. In particular, the lab focuses on dissecting the roles of epigenetic regulators of cancer metastasis, immune evasion, and drug resistance, as well as developing epigenetic drugs.