Guiwu Huang
Associate Research ScientistDownloadHi-Res Photo
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Associate Research Scientist
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Orthopaedics & Rehabilitation
Visiting Research ScientistPrimaryOrthopaedics & Rehabilitation
Associate Research ScientistPrimary
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Yale Co-Authors
Frequent collaborators of Guiwu Huang's published research.
Chuan-Ju Liu, PhD
Stephen Waxman, MD, PhD
Wenyu Fu
Xiangli Zhao
Publications
2024
Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis
Fu W, Vasylyev D, Bi Y, Zhang M, Sun G, Khleborodova A, Huang G, Zhao L, Zhou R, Li Y, Liu S, Cai X, He W, Cui M, Zhao X, Hettinghouse A, Good J, Kim E, Strauss E, Leucht P, Schwarzkopf R, Guo E, Samuels J, Hu W, Attur M, Waxman S, Liu C. Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis. Nature 2024, 625: 557-565. PMID: 38172636, PMCID: PMC10794151, DOI: 10.1038/s41586-023-06888-7.Peer-Reviewed Original ResearchCitationsAltmetricConceptsVoltage-gated sodium channelsOA progressionDorsal root ganglion neuronsStructural joint damagePain relief treatmentHuman OA chondrocytesCommon joint diseaseMultiple mouse modelsNav1.7 blockersPain behaviorGanglion neuronsPharmacological blockadeJoint damageJoint degenerationChannel blockersJoint diseaseOA chondrocytesMouse modelTherapeutic targetOsteoarthritisIntracellular Ca2Nav1.7Nav1.7 channelsGenetic ablationLimited evidence
2023
CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis
Wen X, Fang G, Li H, Jiang Z, Du X, Liao Z, Liu R, Huang G, Meng F, Liao W, Zhang Z. CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis. International Journal Of Biological Macromolecules 2023, 256: 128453. PMID: 38016613, DOI: 10.1016/j.ijbiomac.2023.128453.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTherapeutic effectCartilage degenerationMesenchymal stem cell therapyLimited treatment optionsIntra-articular injectionMSC therapeutic effectsProinflammatory cytokine mRNADegenerative joint diseaseDMM mouse modelNew therapeutic targetsHigher OARSI scoresStem cell therapyChronic inflammationIL-1βTreatment optionsOARSI scoresJoint diseaseCytokine mRNAMouse modelCombination of MSCTherapeutic targetIL6 mRNAOA cartilageOsteoarthritisInflammation
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